Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Sachindra Sachindra"'
Autor:
Sachindra Sachindra, Teresa Hellberg, Samantha Exner, Sonal Prasad, Nicola Beindorff, Stephan Rogalla, Richard Kimura, Sanjiv Sam Gambhir, Bertram Wiedenmann, Carsten Grötzinger
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
IntroductionPancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignant neoplasms, as many cases go undetected until they reach an advanced stage. Integrin αvβ6 is a cell surface receptor overexpressed in PDAC. Consequently, it
Externí odkaz:
https://doaj.org/article/18078cbd95024e42825a22c9aa53eef7
Autor:
Samantha Exner, Claudia Schuldt, Sachindra Sachindra, Jing Du, Isabelle Heing-Becker, Kai Licha, Bertram Wiedenmann, Carsten Grötzinger
Publikováno v:
Cancers, Vol 12, Iss 11, p 3138 (2020)
This study identified and confirmed angiotensin II (ATII) as a strong activator of signaling in neuroendocrine neoplasm (NEN) cells. Expression analyses of the ATII receptor type 1 (AGTR1) revealed an upregulation of mRNA levels (RT-qPCR) and radioli
Externí odkaz:
https://doaj.org/article/99d612c99e2a4945affbb4b5e69257c5
Autor:
Lionel Larribère, Gretchen Wolff, Marlene Vierthaler, Verónica Madrigal-Gamboa, Viktor Umansky, Qian Sun, Jochen Utikal, Thomas Hielscher, Aniello Federico, Karol Granados, Daniel Novak, Sachindra Sachindra, Laura Hüser
Publikováno v:
British Journal of Cancer
Background Drug resistance remains as one of the major challenges in melanoma therapy. It is well known that tumour cells undergo phenotypic switching during melanoma progression, increasing melanoma plasticity and resistance to mitogen-activated pro
Autor:
Jochen Utikal, Daniel B. Lipka, Lionel Larribère, Aniello Federico, Christoffer Gebhardt, Laura Hüser, Sachindra Sachindra, Christoph Plass, Daniel Novak, Karol Granados, Yassen Assenov, Viktor Umansky, Elias Orouji
Publikováno v:
International Journal of Cancer. 145:3462-3477
Alterations in histone modifications play a crucial role in the progression of various types of cancer. The histone methyltransferase SETDB1 catalyzes the addition of methyl groups to histone H3 at lysine 9. Here, we describe how overexpression of SE
Autor:
Sachindra, Sachindra, Hellberg, Teresa, Exner, Samantha, Prasad, Sonal, Beindorff, Nicola, Rogalla, Stephan, Kimura, Richard, Gambhir, Sanjiv Sam, Wiedenmann, Bertram, Grötzinger, Carsten
Introduction: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignant neoplasms, as many cases go undetected until they reach an advanced stage. Integrin avß6 is a cell surface receptor overexpressed in PDAC. Consequently, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f741a92fe7345a74af3c5b736896fa06
Autor:
Exner, Samantha, Schuldt, Claudia, Sachindra, Sachindra, Du, Jing, Heing-Becker, Isabelle, Licha, Kai, Wiedenmann, Bertram, Grötzinger, Carsten
Publikováno v:
Cancers, Vol 12, Iss 3138, p 3138 (2020)
Cancers
Volume 12
Issue 11
Cancers
Volume 12
Issue 11
This study identified and confirmed angiotensin II (ATII) as a strong activator of signaling in neuroendocrine neoplasm (NEN) cells. Expression analyses of the ATII receptor type 1 (AGTR1) revealed an upregulation of mRNA levels (RT-qPCR) and radioli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d873269ac2f50f130ba6b12ef5a8891
Autor:
Jochen Utikal, Laura Hüser, Peter Altevogt, Lionel Larribère, Aniello Federico, Viktor Umansky, Daniel Novak, Karol Granados, Sachindra Sachindra
Publikováno v:
International Journal of Cancer. 143:3131-3142
Melanoma is often characterized by a constitutively active RAS-RAF-MEK-ERK pathway. For targeted therapy, BRAF inhibitors are available that are powerful in the beginning but resistance occurs rather fast. A better understanding of the mechanisms of
Autor:
Karol Granados, Lionel Larribère, Jochen Utikal, Qian Sun, Huizi Wu, Viktor Umansky, Daniel Novak, Sachindra Sachindra
Publikováno v:
International Journal of Cancer. 143:2962-2972
Recent studies suggest that malignant melanoma heterogeneity includes subpopulations of cells with features of multipotent neural crest (NC) cells. Zebrafish and mouse models have shown that reactivation of neural crest-specific pathways during trans
Autor:
Kai Licha, Bertram Wiedenmann, Sachindra Sachindra, Carsten Groetzinger, Claudia Schuldt, Isabelle Heing-Becker, Samantha Exner, Jing Du
Peptide receptor targeting has proven to be a pivotal tool for diagnostic imaging and radioligand therapy of neuroendocrine neoplasms (NENs), which frequently express somatostatin receptors (SSTRs) on their cell surface. However, up to 30 % of NEN pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c8a7b03695b15d1b6fc0c48760d667
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