Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Sachindra R. Joshi"'
Autor:
Sachindra R. Joshi, Jun Liu, Troy Bloom, Elif Karaca Atabay, Tzu-Hsing Kuo, Michael Lee, Elitza Belcheva, Matthew Spaits, Rosa Grenha, Michelle C. Maguire, Jeffrey L. Frost, Kathryn Wang, Steven D. Briscoe, Mark J. Alexander, Brantley R. Herrin, Roselyne Castonguay, R. Scott Pearsall, Patrick Andre, Paul B. Yu, Ravindra Kumar, Gang Li
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Sotatercept is an activin receptor type IIA-Fc (ActRIIA-Fc) fusion protein that improves cardiopulmonary function in patients with pulmonary arterial hypertension (PAH) by selectively trapping activins and growth differentiation factors. How
Externí odkaz:
https://doaj.org/article/30b6e26c2ac54524a92a73737016bed3
Autor:
Sachindra R. Joshi, Elif Karaca Atabay, Jun Liu, Yan Ding, Steven D. Briscoe, Mark J. Alexander, Patrick Andre, Ravindra Kumar, Gang Li
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Pulmonary hypertension due to left heart disease (PH-LHD) is the most frequent manifestation of PH but lacks any approved treatment. Activin receptor type IIA-Fc fusion protein (ActRIIA-Fc) was found previously to be efficacious in experimental and h
Externí odkaz:
https://doaj.org/article/ac6f6806ca7e4eb689d4ee5a9d228f53
Autor:
Patrick Andre, Sachindra R. Joshi, Steven D. Briscoe, Mark J. Alexander, Gang Li, Ravindra Kumar
Publikováno v:
Frontiers in Medicine, Vol 8 (2022)
Pulmonary arterial hypertension (PAH) is a rare disease characterized by high blood pressure in the pulmonary circulation driven by pathological remodeling of distal pulmonary arteries, leading typically to death by right ventricular failure. Availab
Externí odkaz:
https://doaj.org/article/f8699ba963934b06b821ed7462350abe
Autor:
William M. Scovell, Sachindra R. Joshi
Publikováno v:
AIMS Molecular Science, Vol 2, Iss 2, Pp 48-63 (2015)
Estrogen receptor alpha (ERα) plays a major role in the expression of estrogen-responsive genes. Although its conventional binding characteristics have been considered coincident with & exclusively in the class of steroid hormone receptors, increasi
Externí odkaz:
https://doaj.org/article/1635683fe71545aca58d3e7c6e499841
Autor:
Dimitri Laurent, Leonard M. Eisenberg, Sachindra R. Joshi, Elizabeth Sira, Maria A. Mitry, Carol A. Eisenberg, John G. Edwards, Sachin A. Gupte, Britny L. Keith
Publikováno v:
Am J Physiol Cell Physiol
Children surviving cancer and chemotherapy are at risk for adverse health events including heart failure that may be delayed by years. Although the early effects of doxorubicin-induced cardiotoxicity may be attributed to a direct effect on the cardio
Autor:
Jared M. McLendon, Masahiko Oka, Ivan F. McMurtry, Kaori Oshima, Kohtaro Abe, Yuri Matsumoto, Edward S. Crockett, Sachindra R. Joshi
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Histological observations in human pulmonary arterial hypertension (PAH) suggest a link between plexiform lesions and pulmonary supernumerary arteries. Pulmonary microvascular endothelial cells are characterized as hyperproliferative and progenitor-l
Publikováno v:
Circulation. 144
Introduction: Pulmonary hypertension (PH) due to heart failure with preserved ejection fraction (PH-HFpEF) is the most prevalent form of WHO Group 2 PH but lacks effective treatment options. We previously found that sequestration of activins and grow
Publikováno v:
Circulation. 142
IIntroduction: Right ventricular (RV) failure is the primary cause of death in patients with pulmonary arterial hypertension (PAH). Beneficial effects of sotatercept - an activin receptor type IIA-Fc fusion protein that traps activins and growth diff
Publikováno v:
Pulmonary hypertension.
Background: Beneficial effects of sotatercept – an activin receptor type IIA-Fc (ActRIIA-Fc) fusion protein that traps multiple members of the TGF-β superfamily, including activins and growth differentiation factors – have been reported in PAH p
Autor:
Po Sheng Chen, Sergio Poli De Frias, Lai Ming Yung, Gang Li, Megan E. McNeil, Zachary M. Augur, Teresa Dinter, Mark Southwood, R. Scott Pearsall, Paul B. Yu, Luca Troncone, Sachindra R Joshi, Stephanie S.J. Kim, Ivan O. Rosas, Sako Dianne S, Peiran Yang, John D Quisel, Geoffrey A. Bocobo, Ravindra Kumar, John Knopf
Publikováno v:
Sci Transl Med
Human genetics, biomarker, and animal studies implicate loss of function in bone morphogenetic protein (BMP) signaling and maladaptive transforming growth factor-β (TGFβ) signaling as drivers of pulmonary arterial hypertension (PAH). Although shari