Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sachin Lohani"'
Autor:
Nelo R. Rivera, Ryan D. Cohen, Si-Wei Zhang, Zachary E. X. Dance, Holst M. Halsey, Siqing Song, Xiaodong Bu, Mikhail Reibarkh, Hong Ren, Alfred Y. Lee, Darryl Chang, Sachin Lohani
Publikováno v:
Organic Process Research & Development. 27:286-294
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4808f18942b26079e70ab9fbc5687256
https://doi.org/10.1021/acs.oprd.2c00313
https://doi.org/10.1021/acs.oprd.2c00313
Autor:
Imad A. Haidar Ahmad, Gioacchino Luca Losacco, Margaret Figus, Deepa Korani, Matthew J. Gunsch, Hayley R. Lhotka, Kari Hullen, Robert Hartman, Sachin Lohani, Simon Hamilton, Ian Mangion, Erik L. Regalado
Publikováno v:
SEPARATION SCIENCE PLUS. 5:138-145
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::237bab6300676abda3d00ab7a7cd9c24
https://doi.org/10.1002/sscp.202200002
https://doi.org/10.1002/sscp.202200002
Autor:
Tianyu Yuan, Dolee Merai, Matthew J. Gunsch, Ryan Peters, Sachin Lohani, Frank Bernardoni, Michael A. Zompa, Imad Haidar Ahmad, Erik L. Regalado, Christopher A. Pohl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90a5a35aca968010b746501c7c730ed0
https://doi.org/10.2139/ssrn.4396642
https://doi.org/10.2139/ssrn.4396642
Autor:
Rebecca A. Arvary, Michael J. Di Maso, Darryl Chang, Sachin Lohani, Francisco J. Guzman, Lisa Jellett, Ralph Zhao, Hong Ren, Michael A. Zompa, Siqing Song
Publikováno v:
Organic Process Research & Development. 25:1937-1942
The manufacturing route toward gefapixant citrate generates a trace amount of cyanide as a byproduct of a reaction employing the reagent chloroacetonitrile. In the development of a cyanide control ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7172ebda87e07734b28fe7c5ad11a539
https://doi.org/10.1021/acs.oprd.1c00185
https://doi.org/10.1021/acs.oprd.1c00185
Autor:
Imad A. Haidar Ahmad, Gioacchino Luca Losacco, Margaret Figus, Deepa Korani, Matthew J. Gunsch, Hayley R. Lhotka, Kari Hullen, Robert Hartman, Sachin Lohani, Simon Hamilton, Ian Mangion, Erik L. Regalado
Publikováno v:
SEPARATION SCIENCE PLUS. 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b495c8b739b9423e1c6c7607ea4040d
https://doi.org/10.1002/sscp.202270031
https://doi.org/10.1002/sscp.202270031
Autor:
Michael J. Di Maso, Embarek Alwedi, Guy R. Humphrey, Richard Desmond, Louis-Charles Campeau, Lisa Jellett, John R. Naber, Hong Ren, Hsieh Yao D. Chang, Douglas A. L. Otte, Hong Gao, Michael A. Zompa, Si-Wei Zhang, Gary E. Martin, Alfred Y. Lee, Wenjun Liu, Francisco J. Guzman, Kevin M. Maloney, Feng Peng, Elizabeth Fisher, Rebecca T. Ruck, Dan Lehnherr, Anne E. Mohan, Glenn Spencer, Siqing Song, Kallol Basu, Rebecca A. Arvary, Sachin Lohani
Publikováno v:
Organic Process Research & Development. 24:2445-2452
A robust, green, and sustainable manufacturing process has been developed for the synthesis of gefapixant citrate, a P2X3 receptor antagonist that is under investigation for the treatment of refrac...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95c8b1da5db499a674207974d58e42c1
https://doi.org/10.1021/acs.oprd.0c00248
https://doi.org/10.1021/acs.oprd.0c00248
Autor:
Chunli Huang, Siqing Song, Wenjun Liu, Priya Parganiha, Ping Zhuang, Sachin Lohani, Embarek Alwedi, Hong Ren, Daniel Bishara, Hsieh Yao D. Chang
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 215
Control of process impurities during manufacturing of drug substance is critical to ensure quality and process robustness. During commercial process development for the gefapixant citrate drug substance, several process impurities were found to deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02a42fbc241e333a46ab8bb2f85acbf
https://pubmed.ncbi.nlm.nih.gov/35483232
https://pubmed.ncbi.nlm.nih.gov/35483232
Autor:
Chunli Huang, Siqing Song, Wenjun Liu, Priya Parganiha, Ping Zhuang, Sachin Lohani, Embarek Alwedi, Hong Ren, Daniel Bishara, Hsieh Yao D. Chang
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24c7a76beb51c3af02c27217364e1e2d
https://doi.org/10.2139/ssrn.3992378
https://doi.org/10.2139/ssrn.3992378
Autor:
Becky Nissley, Xiaoling Jin, Sachin Lohani, John Cummings, Kimberly Manser, Harriet L.R. Cooper, Scott Fauty, Annette Bak, Linda Huong Rakes
Publikováno v:
Journal of Pharmaceutical Sciences. 103:3007-3021
This work summarizes the pharmaceutical evaluation of a preclinical drug candidate with poor physicochemical properties. Compound 1 is a weakly basic, GPR‐119 agonist designated to Biopharmaceutics Classification System Class II because of good per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef60c19627ae1467d677951e13d5075
https://doi.org/10.1002/jps.24088
https://doi.org/10.1002/jps.24088
Autor:
Richard G. Ball, Nicole Canfield, Yaling Wang, Annette Bak, Dennis Leung, Sachin Lohani, Timothy Rhodes
Publikováno v:
Crystal Growth & Design. 12:1254-1262
A streamlined methodology for cocrystal screening and scale-up has been developed. There are two parts to this procedure: (1) a high throughput screening approach for the rapid identification of potential cocrystal leads and (2) a new procedure for s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13a7baa50ac6d7faeeaa703ba71c6d19
https://doi.org/10.1021/cg201270s
https://doi.org/10.1021/cg201270s