Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Sachin Kotak"'
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113495- (2023)
Summary: Nuclear envelope (NE) disassembly during mitosis is critical to ensure faithful segregation of the genetic material. NE disassembly is a phosphorylation-dependent process wherein mitotic kinases hyper-phosphorylate lamina and nucleoporins to
Externí odkaz:
https://doaj.org/article/112063fa74cd493fb7791c1b1b5ae115
Autor:
Sachin Kotak
Publikováno v:
Biomolecules, Vol 9, Iss 2, p 80 (2019)
Proper positioning of the mitotic spindle is fundamental for specifying the site for cleavage furrow, and thus regulates the appropriate sizes and accurate distribution of the cell fate determinants in the resulting daughter cells during development
Externí odkaz:
https://doaj.org/article/fcd3d5796a2e466a9349d56ee765d87d
In animal cells, spindle elongation during anaphase is temporally coupled with cleavage furrow formation. Spindle elongation during anaphase is regulated by NuMA/dynein/dynactin complexes that occupy the polar region of the cell membrane and are excl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f95143fe7824ce8bb6618deb3848b8cd
https://doi.org/10.1101/2022.03.29.486209
https://doi.org/10.1101/2022.03.29.486209
Membrane compartmentalization of Ect2/Cyk4/Mklp1 and NuMA/dynein regulates cleavage furrow formation
Publikováno v:
The Journal of cell biology. 221(12)
In animal cells, spindle elongation during anaphase is temporally coupled with cleavage furrow formation. Spindle elongation during anaphase is regulated by NuMA/dynein/dynactin complexes that occupy the polar region of the cell membrane and are excl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b4eab468ce87a0ed981adb93275ef46
https://pubmed.ncbi.nlm.nih.gov/36197340
https://pubmed.ncbi.nlm.nih.gov/36197340
NuMA is an abundant long-coiled-coil protein that plays a prominent role in spindle organization during mitosis. In interphase, NuMA is localized to the nucleus and hypothesized to control gene expression and chromatin organization. However, because
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2470c174b2a1861700a7812c9bc2d7
Autor:
Sachin Kotak, Sukriti Kapoor
Publikováno v:
Biochemical Society transactions. 48(3)
Cellular asymmetries are vital for generating cell fate diversity during development and in stem cells. In the newly fertilized Caenorhabditis elegans embryo, centrosomes are responsible for polarity establishment, i.e. anterior–posterior body axis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7889fbbbecf939664bd467ce16130d98
https://pubmed.ncbi.nlm.nih.gov/32597472
https://pubmed.ncbi.nlm.nih.gov/32597472
Publikováno v:
J Cell Sci
Proper orientation of the mitotic spindle is critical for accurate development and morphogenesis. In human cells, spindle orientation is regulated by the evolutionarily conserved protein NuMA, which interacts with dynein and enriches it at the cell c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2affbfb3968e24ac356d04b6bc8fcd7
https://doi.org/10.1242/jcs.243857
https://doi.org/10.1242/jcs.243857
Publikováno v:
Planta. 251(1)
Silencing of CI-sHsps by RNAi negatively affected the seed germination process and heat stress response of rice seedlings. Seed size of RNAiCI-sHsp was reduced as compared to wild-type plants. Small heat shock proteins (sHsps) are the ATP-independent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f173ecc2cab93952ff29501dad15d269
https://pubmed.ncbi.nlm.nih.gov/31797121
https://pubmed.ncbi.nlm.nih.gov/31797121
Autor:
Sukriti, Kapoor, Sachin, Kotak
Publikováno v:
Development
Proper establishment of cell polarity is essential for development. In the one-cell C. elegans embryo, a centrosome-localised signal provides spatial information for polarity establishment. It is hypothesised that this signal causes local inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::250e458a4392dbf5820065a85bbd43d5
https://pubmed.ncbi.nlm.nih.gov/31636075
https://pubmed.ncbi.nlm.nih.gov/31636075
Autor:
Sachin Kotak, Silvan D. Boss, Pierre Gönczy, Mahendra Awale, Jean-Louis Reymond, Maria J. Marcaida, Thomas Schick, Falco Kilchmann
Publikováno v:
Journal of medicinal chemistry
Here we report the discovery of a selective inhibitor of Aurora A, a key regulator of cell division and potential anticancer target. We used the atom category extended ligand overlap score (xLOS), a 3D ligand-based virtual screening method recently d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b7e44e14199cb5fa7d72bf28e107f4
https://doi.org/10.1021/acs.jmedchem.6b00709
https://doi.org/10.1021/acs.jmedchem.6b00709