Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Sachin Katyal"'
Autor:
Jiayu Yang, Lin Yang, Bryan Tordon, Oliver Bucher, Zoann Nugent, Ivan Landego, Nicole Bourrier, Kelsey Uminski, Kevin Brown, Mandy Squires, Aaron J. Marshall, Sachin Katyal, Salah Mahmud, Kathleen Decker, Marc Geirnaert, David E. Dawe, Spencer B. Gibson, James B. Johnston, Versha Banerji
Publikováno v:
Current Oncology, Vol 30, Iss 7, Pp 6411-6431 (2023)
FISH cytogenetics, TP53 sequencing, and IGHV mutational status are increasingly used as prognostic and predictive markers in chronic lymphocytic leukemia (CLL), particularly as components of the CLL International Prognostic Index (CLL-IPI) and in dir
Externí odkaz:
https://doaj.org/article/7bad489516bf4cf980412144ad8710cb
Autor:
Yongqiang Chen, Sara E. F. Kost, Xiaoyan Yang, Versha Banerji, James B. Johnston, Sachin Katyal, Spencer B. Gibson
Publikováno v:
Autophagy Reports, Vol 2, Iss 1 (2023)
Venetoclax (VCX) is a BCL2 inhibitor approved for treating B cell-derived leukemia, including chronic lymphocytic leukemia (CLL). VCX’s role in apoptosis induction is well-defined, whereas its other mechanistic roles need to be clarified. Autophagy
Externí odkaz:
https://doaj.org/article/d368c74e59604da4b9c7a7efa9b15608
Autor:
Sara E. F. Kost, Ali Saleh, Shek H. Yuan, Bozena Kuzio, Spencer B. Gibson, Lin Yang, Versha Banerji, James B. Johnston, Sachin Katyal
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-6 (2023)
Externí odkaz:
https://doaj.org/article/e34c662d8664434799517621bac19be1
Autor:
Asha Sinha, Ali Saleh, Raelene Endersby, Shek H. Yuan, Chirayu R. Chokshi, Kevin R. Brown, Bozena Kuzio, Tiina Kauppinen, Sheila K. Singh, Suzanne J. Baker, Peter J. McKinnon, Sachin Katyal
Publikováno v:
Cancers, Vol 12, Iss 11, p 3178 (2020)
PTEN mutation occurs in a variety of aggressive cancers and is associated with poor patient outcomes. Recent studies have linked mutational loss of PTEN to reduced RAD51 expression and function, a key factor involved in the homologous recombination (
Externí odkaz:
https://doaj.org/article/5480278c170445bcbfa864e70ea12f8b
Autor:
Amandeep Singh, Meghan Azad, Miriam D Shymko, Elizabeth S Henson, Sachin Katyal, David D Eisenstat, Spencer B Gibson
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0204792 (2018)
The BH3-only family member BNIP3 has been described as either promoting cell survival or cell death. This depends upon the level of BNIP3 expression and its cellular localization. Increased BNIP3 expression under hypoxia contributes to cell death thr
Externí odkaz:
https://doaj.org/article/279e629601cb48f3bc53e7333c5ad6ea
Autor:
Sara E. F. Kost, Ali Saleh, Edgard M. Mejia, Marina Mostafizar, Eric D. J. Bouchard, Versha Banerji, Aaron J. Marshall, Spencer B. Gibson, James B. Johnston, Sachin Katyal
Publikováno v:
Cancers, Vol 11, Iss 10, p 1519 (2019)
The phosphatidyl-inositol 3 kinase (PI3K) δ inhibitor, idelalisib (IDE), is a potent inhibitor of the B-cell receptor pathway and a novel and highly effective agent for the treatment of chronic lymphocytic leukemia (CLL). We evaluated the activities
Externí odkaz:
https://doaj.org/article/bad6e330d5f14867a915bd67a1982dce
Autor:
Deniz Simsek, Erika Brunet, Sunnie Yan-Wai Wong, Sachin Katyal, Yankun Gao, Peter J McKinnon, Jacqueline Lou, Lei Zhang, James Li, Edward J Rebar, Philip D Gregory, Michael C Holmes, Maria Jasin
Publikováno v:
PLoS Genetics, Vol 7, Iss 6, p e1002080 (2011)
Nonhomologous end-joining (NHEJ) is the primary DNA repair pathway thought to underlie chromosomal translocations and other genomic rearrangements in somatic cells. The canonical NHEJ pathway, including DNA ligase IV (Lig4), suppresses genomic instab
Externí odkaz:
https://doaj.org/article/4396a48b6f3a49508178da39b80ec8e7
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28579 (2011)
The Reelin-Dab1 signaling pathway plays a critical role in the positioning of migrating neurons, dendrite formation and lamination in the developing central nervous system. We have previously identified two alternatively spliced forms of Dab1 in the
Externí odkaz:
https://doaj.org/article/aa86652d07c543d48809c281c42f6016
Autor:
Banerji, Jiayu Yang, Lin Yang, Bryan Tordon, Oliver Bucher, Zoann Nugent, Ivan Landego, Nicole Bourrier, Kelsey Uminski, Kevin Brown, Mandy Squires, Aaron J. Marshall, Sachin Katyal, Salah Mahmud, Kathleen Decker, Marc Geirnaert, David E. Dawe, Spencer B. Gibson, James B. Johnston, Versha
Publikováno v:
Current Oncology; Volume 30; Issue 7; Pages: 6411-6431
FISH cytogenetics, TP53 sequencing, and IGHV mutational status are increasingly used as prognostic and predictive markers in chronic lymphocytic leukemia (CLL), particularly as components of the CLL International Prognostic Index (CLL-IPI) and in dir
Autor:
Divya Prasad, Manzoor Ahmad, Sachin Katyal, Ajay K Thakral, Musharraf Husain, Mohammad Mohsin
Publikováno v:
Cureus. 14(3)
Background and objective Liver abscesses are one of the common surgical diseases to be treated as an emergency in any tertiary care hospital in India. The formation of abscesses in the liver is still a major problem and associated with significant mo