Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sachiko Takaishi"'
Autor:
Shoji Yamamoto, Tomoki Ishikawa, Yasuhide Hirota, Shinji Tsutsumi, Naoya Wada, Hiroki Goto, Makoto Hirasawa, Kazunori Fujimoto, Tomoko Shibutani, Naoyuki Maeda, Hideo Yukinaga, Kumiko Kadoshima-Yamaoka, Sachiko Takaishi, Naomi Shimazaki, Taiga Kato, Hidenori Namiki, Yohei Yoshihama
Targeting collateral deletion of housekeeping genes caused by the loss of tumor suppressor genes is a potential strategy to identify context-specific, molecular-targeted therapies in cancer. In mammals, phosphatidylserine (PS) synthesis depends on tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373304c3ddb0696118e2c45d2a306567
https://doi.org/10.1158/0008-5472.c.6514185.v1
https://doi.org/10.1158/0008-5472.c.6514185.v1
Autor:
Yohei Yoshihama, Hidenori Namiki, Taiga Kato, Naomi Shimazaki, Sachiko Takaishi, Kumiko Kadoshima-Yamaoka, Hideo Yukinaga, Naoyuki Maeda, Tomoko Shibutani, Kazunori Fujimoto, Makoto Hirasawa, Hiroki Goto, Naoya Wada, Shinji Tsutsumi, Yasuhide Hirota, Tomoki Ishikawa, Shoji Yamamoto
Publikováno v:
Cancer research. 82(21)
Targeting collateral deletion of housekeeping genes caused by the loss of tumor suppressor genes is a potential strategy to identify context-specific, molecular-targeted therapies in cancer. In mammals, phosphatidylserine (PS) synthesis depends on tw
Autor:
Masahiro Ota, Yoshimi Takata, Kanae Suzuki, Makoto Suzuki, Yasuhide Hirota, Kaori Ono, Takashi Asahi, Shinji Tsutsumi, Hidekazu Inoue, Junya Kawai, Tadashi Toki, Sachiko Takaishi, Kiyoshi Nakayama, Hitoshi Ohki, Takashi Shimada, Satoshi Matsui
Publikováno v:
Journal of medicinal chemistry. 62(22)
We report the discovery of a potent and isozyme-selective MTHFD2 inhibitor, DS18561882 (2). Through investigation of the substituents on our tricyclic coumarin scaffold (1,2,3,4-tetrahydrochromeno[...
Autor:
Junya Kawai, Makoto Suzuki, Chika Sugihara, Satoshi Matsui, Kiyoshi Nakayama, Masahiro Ota, Hitoshi Ohki, Norikazu Matsuhashi, Sachiko Takaishi, Takashi Shimada, Yumi Matsui, Hidekazu Inoue, Tadashi Toki
Publikováno v:
ACS Med Chem Lett
[Image: see text] Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) plays a key role in one-carbon (1C) metabolism in human mitochondria, and its high expression correlates with poor survival of patients with various types of cancer. An isozyme-sele
Autor:
Hitoshi Hayasaka, Hiroyuki Hanzawa, Takashi Asahi, Shin-ichi Katakura, Isao Yasumatsu, Kazuo Kanai, Osamu Ubukata, Sachiko Takaishi, Takahiro Kitamura, Yumi Matsui
Publikováno v:
Bioorganicmedicinal chemistry. 25(13)
Tumor cells switch glucose metabolism to aerobic glycolysis by expressing the pyruvate kinase M2 isoform (PKM2) in a low active form, providing glycolytic intermediates as building blocks for biosynthetic processes, and thereby supporting cell prolif
Autor:
Miyuki Nagasaki, Tomoaki Komai, Tomiichiro Oda, Ikue Iino, Hiroaki Maeda, Sachiko Takaishi, Masakatsu Suzuki, Yoshiko Onozawa
Publikováno v:
Journal of Biological Chemistry. 288:10684-10691
G protein-coupled receptor 84 (GPR84) is a putative receptor for medium-chain fatty acids (MCFAs), whose pathophysiological roles have not yet been clarified. Here, we show that GPR84 was activated by MCFAs with the hydroxyl group at the 2- or 3-posi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 48:505-508
Activity-guided fractionation of twigs of Pistacia chinensis resulted in the isolation and characterization of two novel ingredients as potent estrogen agonists. On the basis of spectral analysis and comparison with a related compound their structure
Autor:
Emiko Minami, Motohiko Taki, Yasuteru Iijima, Sachiko Takaishi, Toshiyuki Akiyama, Shinya Tsutsumi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 48:389-392
Naturally occurring phenylpropanoids, hinokiresinol (trans-hinokiresinol) and nyasol (cis-hinokiresinol) were found to possess appreciable estrogen receptor binding activity. Strong differences in activity were observed between the geometrical isomer
Autor:
Yoichi Matsushita, Aiya Sato, Tohru Watanabe, Takeshi Kinoshita, Yasuyuki Takamatsu, Momoyo Tanaka, Sachiko Takaishi, Kentaro Kodama, Hideyuki Haruyama, Yasuteru Iijima, Teruaki Negishi, Naoko Tuchiya
Publikováno v:
The Journal of Antibiotics. 51:805-815
A novel endothelin-converting enzyme (ECE) inhibitor, B-90063, was isolated from the culture supernatant of the newly discovered marine bacterium Blastobacter sp. SANK 71894. Based on spectral analyses and chemical reactions, the structure of B-90063
Isolation of 10-Hydroxycoronaridine from Tabernaemontana penduliflora and its Estrogen-Like Activity
Autor:
Yasuteru Iijima, Toshiyuki Akiyama, Sachiko Takaishi, Motohiko Taki, Johnson Jato, Kayoko Masuda, Norio Aimi, Peter G. Waterman, Mikio Yamazaki
Publikováno v:
Planta Medica. 66:169-171
The methanol extract of Tabernaemontana penduliflora was found to appreciably inhibit [ 3 H]-estradiol binding to estrogen receptors. Activity-guided fractionation led to the isolation of two known alkaloids, 10-hydroxycoronaridine (1) and its 10-O-m