Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Sachiko Sakakibara"'
1
Akademický článek
Booster vaccination using bivalent DS-5670a/b is safe and immunogenic against SARS-CoV-2 variants in children aged 5–11 years: a phase 2/3, randomized, active-controlled study
Autor: Rino Suzuki, Miharu Suda, Katsuyasu Ishida, Kei Furihata, Aisaku Ota, Kaori Takahashi, Sachiko Sakakibara, Tetsuo Nakayama, Fumihiko Takeshita
Publikováno v: Frontiers in Immunology, Vol 15 (2024)
BackgroundDS-5670 is a messenger ribonucleic acid (mRNA) vaccine platform targeting the receptor-binding domain (RBD) of the spike protein derived from severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Booster vaccination against coronavi
Externí odkaz: https://doaj.org/article/efa4d48f532142d9ae42ac6e676a2296
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2
Akademický článek
Detection of Dystrophin Dp71 in Human Skeletal Muscle Using an Automated Capillary Western Assay System
Autor: Tatsuya Kawaguchi, Emma Tabe Eko Niba, Abdul Qawee Mahyoob Rani, Yoshiyuki Onishi, Makoto Koizumi, Hiroyuki Awano, Masaaki Matsumoto, Masashi Nagai, Shinobu Yoshida, Sachiko Sakakibara, Naoyuki Maeda, Osamu Sato, Hisahide Nishio, Masafumi Matsuo
Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 6, p 1546 (2018)
Background: Dystrophin Dp71 is one of the isoforms produced by the DMD gene which is mutated in patients with Duchenne muscular dystrophy (DMD). Although Dp71 is expressed ubiquitously, it has not been detected in normal skeletal muscle. This study w
Externí odkaz: https://doaj.org/article/904ff82e978341909303abe5fb3b17d4
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3
Detection of Dystrophin Dp71 in Human Skeletal Muscle Using an Automated Capillary Western Assay System
Autor: Hiroyuki Awano, Sachiko Sakakibara, Osamu Sato, Emma Tabe Eko Niba, Masashi Nagai, Yoshiyuki Onishi, Masaaki Matsumoto, Naoyuki Maeda, Abdul Qawee Mahyoob Rani, Hisahide Nishio, Makoto Koizumi, Tatsuya Kawaguchi, Shinobu Yoshida, Masafumi Matsuo
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 19; Issue 6; Pages: 1546
International Journal of Molecular Sciences, Vol 19, Iss 6, p 1546 (2018)
Background: Dystrophin Dp71 is one of the isoforms produced by the DMD gene which is mutated in patients with Duchenne muscular dystrophy (DMD). Although Dp71 is expressed ubiquitously, it has not been detected in normal skeletal muscle. This study w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91150dda70027f59185c51edf0a99181
http://www.lib.kobe-u.ac.jp/handle_kernel/90005080
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4
Benzimidazoles as non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists. Part 3: Discovery of 1-(1H-benzimidazol-5-yl)-3-tert-butylurea derivatives
Autor: Makoto Shimazaki, Yuka Shogase, Miyuki Tatsuta, Klaus Urbahns, Kayo Yasoshima, Noriyuki Yamamoto, Sachiko Sakakibara, Jang Bahadur Gupta, Takeshi Yura, Li Yingfu, Mikayo Kataoka
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 15:2265-2269
1-(1H-Benzimidazol-5-yl)-3-tert-butylurea derivatives have been identified as a novel class of non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists. Herein, we disclose the synthesis and structure–activity relationships (SAR) of thi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028120e46098fb55ee05faac9e9f446b
https://doi.org/10.1016/j.bmcl.2005.03.030
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5
Synthesis and structure–activity relationships of novel IKK-β inhibitors. Part 3: Orally active anti-inflammatory agents
Autor: Kevin Bacon, Keiko Fukushima, Koriyama Yuji, Yamauchi Megumi, Nunami Noriko, Mitsuyuki Shimada, Yoshino Takashi, Karl Ziegelbauer, Akihiko Watanabe, Tsutomu Masuda, Hiroki Sato, Toshiki Murata, Timothy B. Lowinger, Kinji Fuchikami, Sachiko Sakakibara, Hiroshi Komura, Takuya Shintani
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 14:4019-4022
A series of 2-amino-3-cyano-4-alkyl-6-(2-hydroxyphenyl)pyridine derivatives was synthesized and evaluated as I kappaB kinase beta (IKK-beta) inhibitors. Modification of a novel IKK-beta inhibitor 1 (IKK-beta IC(50)=1500 nM, Cell IC(50)=8000 nM) at th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77aace4de90cf1e1cb250eddf70fa353
https://doi.org/10.1016/j.bmcl.2004.05.041
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6
Synthesis and structure–activity relationships of novel IKK-β inhibitors. Part 2: Improvement of in vitro activity
Autor: Kinji Fuchikami, Sachiko Sakakibara, Tsutomu Masuda, Takuya Shintani, Mitsuyuki Shimada, Karl Ziegelbauer, Yoshino Takashi, Kevin Bacon, Timothy B. Lowinger, Makoto Shimazaki, Toshiki Murata, Hiroshi Kadono
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 14:4013-4017
A series of 2-amino-3-cyano-4-alkyl-6-(2-hydroxyphenyl)pyridine derivatives was synthesized and evaluated as IkappaB kinase beta (IKK-beta) inhibitors. Substitution of an aminoalkyl group for the aromatic group at the 4-position on the core pyridine
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839c3e1f6a82f50eb49c2d0bcc1cd181
https://doi.org/10.1016/j.bmcl.2004.05.040
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7
Discovery of novel and selective IKK-β serine-threonine protein kinase inhibitors. Part 1
Autor: Yoshino Takashi, Keisuke Takeshita, Hiroshi Kadono, Sachiko Sakakibara, Kevin Bacon, Makoto Shimazaki, Mitsuyuki Shimada, Takuya Shintani, Katsuya Sakai, Toshiro Niki, Toshiki Murata, Tsutomu Masuda, Masaomi Umeda, Timothy B. Lowinger, Hisayo Inbe, Karl Ziegelbauer, Kinji Fuchikami
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 13:913-918
IkappaB kinase beta (IKK-beta) is a serine-threonine protein kinase critically involved in the activation of the transcription factor Nuclear Factor kappa B (NF-kappaB) in response to various inflammatory stimuli. We have identified a small molecule
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90956578ea913259b1e747c2766153e6
https://doi.org/10.1016/s0960-894x(02)01046-6
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8
Raldh3 expression in diabetic islets reciprocally regulates secretion of insulin and glucagon from pancreatic islets
Autor: Mitsuru Shimamura, Hiroshi Karasawa, Akira Shinagawa, Sachiko Sakakibara
Publikováno v: Biochemical and biophysical research communications. 401(1)
We have previously reported that obesity-induced diabetes developed in high-fat diet (HFD)-fed BDF1 mice. This is caused by insufficient insulin response to an excess glucose load. In this study, we have shown that the enhanced expression of retinald
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78bab6c99d62176030901a57e03b510f
https://pubmed.ncbi.nlm.nih.gov/20833146
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