Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Sachiko Ohshima"'
Autor:
Marina E. Emborg M.D., Ph.D., Zhijian Zhang, Valerie Joers, Kevin Brunner, Viktorya Bondarenko, Sachiko Ohshima, Su-Chun Zhang
Publikováno v:
Cell Transplantation, Vol 22 (2013)
To explore stem cell therapy for Parkinson's disease (PD), three adult rhesus monkeys were first rendered hemiparkinsonian by unilateral intracarotid 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) infusion. Five months postinfusion, they were gi
Externí odkaz:
https://doaj.org/article/b5e8e3bcdd144c0f97eebd15aef1880c
Autor:
Sachiko Ohshima-Hosoyama, Heather A Simmons, Nichole Goecks, Valerie Joers, Christine R Swanson, Viktoriya Bondarenko, Rebecca Velotta, Kevin Brunner, Laura D Wood, Ralph H Hruban, Marina E Emborg
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39036 (2012)
Glial cell line derived neurotrophic factor (GDNF) is a neurotrophic factor that has neuroprotective effects in animal models of Parkinson's disease (PD) and has been proposed as a PD therapy. GDNF does not cross the blood brain barrier (BBB), and re
Externí odkaz:
https://doaj.org/article/e81c51243a0f4f3e8cf62a64d9a20f6a
Autor:
Laura D. Nelon, Martha A. Hanes, Suresh I. Prajapati, Aoife Kilcoyne, Jinu Abraham, Sangeet Lal, Francis J. Giles, Charles Keller, Monika A. Davare, Brian P. Rubin, Sachiko Ohshima-Hosoyama
Publikováno v:
Journal of Pediatric Hematology/Oncology. 34:116-121
Overexpression of platelet-derived growth factor receptor alpha (PDGFR-A) has been documented in association with primary tumors and metastasis in medulloblastoma. Tumors from our genetically engineered sonic hedgehog-driven medulloblastoma mouse mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e5e948546093e2dd4bf20e393ba3e0
https://doi.org/10.1097/mph.0b013e3182309fe4
https://doi.org/10.1097/mph.0b013e3182309fe4
Autor:
Hironori Okada, Shin'ichi Takeda, Michiko Wada-Maeda, Sachiko Ohshima-Hosoyama, Yuko Nitahara-Kasahara, Takashi Okada, Akinori Nakamura, Hiromi Hayashita-Kinoh
Publikováno v:
Molecular Therapy. 20(1):168-177
Duchenne muscular dystrophy (DMD) is an incurable genetic disease with early mortality. Multipotent mesenchymal stromal cells (MSCs) are of interest because of their ability to differentiate to form myogenic cells in situ. In the present study, metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0598602f243d553503c3521a5181d1a
Publikováno v:
Biochemical and Biophysical Research Communications. 399:727-732
The insulin-like growth factor-1 receptor (Igf1r) is a multifunctional membrane-associated tyrosine kinase associated with regulation of transformation, proliferation, differentiation and apoptosis. Increased IGF pathway activity has been reported in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3396d87645cefda66ae62bdff5d43066
https://doi.org/10.1016/j.bbrc.2010.08.009
https://doi.org/10.1016/j.bbrc.2010.08.009
Autor:
Timothy Q. Duong, Dustin P. Green, Michelle M. Brady, Timothy J. Sledz, Sachiko Ohshima-Hosoyama, Steven D. McCarthy, Francis J. Giles, Brian P. Rubin, Aislynn K. Samano, Suresh I. Prajapati, Lee Ann Zarzabal, Joel E. Michalek, Charles Keller, Barron Blackman, Arun K. Tatiparthy, Aoife Kilcoyne
Publikováno v:
Molecular Imaging and Biology. 13:493-499
The purpose of this paper is to validate a rapid and cost-effective ex vivo technique, microCT-based virtual histology, as an alternative to MRI imaging for assessing the therapeutic response in genetically engineered mouse models of cancer.All anima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5955fdf2d23c2c67669dbfeac6b4a0a2
https://doi.org/10.1007/s11307-010-0372-3
https://doi.org/10.1007/s11307-010-0372-3
Autor:
Charles Keller, Osamu Togao, Aislynn K. Samano, Ai-Ling Lin, Timothy Q. Duong, Laura D. Nelon, William W. Morgan, Aoife Kilcoyne, Inkyung Jung, Brent M. Nowak, Thomas G. Whitney, Suresh I. Prajapati, Brian P. Rubin, Eri Taniguchi, Sachiko Ohshima-Hosoyama
Publikováno v:
Transgenic Research. 19:829-840
Medulloblastoma is an aggressive childhood cerebellar tumor. We recently reported a mouse model with conditional deletion of Patched1 gene that recapitulates many characteristics of the human medulloblastoma. Qualitative symptoms observed in the mous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b91010b19a3a7b6395910cda4cbb65
https://doi.org/10.1007/s11248-010-9361-1
https://doi.org/10.1007/s11248-010-9361-1
Autor:
Jun Ichi Kira, Shin'ichi Takeda, Katsutoshi Yuasa, Akiyo Nishiyama, Takashi Okada, Jin Hong Shin, Sachiko Ohshima
Publikováno v:
Molecular Therapy. 17:73-80
Recombinant adeno-associated virus (rAAV)-mediated gene transfer is an attractive approach to the treatment of Duchenne muscular dystrophy (DMD). We investigated the muscle transduction profiles and immune responses associated with the administration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dba9dbef3485d734131be50dff5ffa3
https://doi.org/10.1038/mt.2008.225
https://doi.org/10.1038/mt.2008.225
Autor:
Arun K. Tatiparthi, Charles Keller, Timothy J. Sledz, Sachiko Ohshima-Hosoyama, Brian P. Rubin, Barron Blackman, Lee Ann Zarzabal, Aoife Kilcoyne, Timothy Q. Duong, Michelle M. Brady, Francis J. Giles, Dustin P. Green, Aislynn K. Samano, Suresh I. Prajapati, Steven D. McCarthy, Joel E. Michalek
Publikováno v:
Molecular Imaging and Biology. 19:483-483
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51f42729527896557b0de571f823445d
https://doi.org/10.1007/s11307-017-1079-5
https://doi.org/10.1007/s11307-017-1079-5
Autor:
Kyle Cummisford, Do P.M. Tromp, Marc Sonnemans, Bas Blits, Christine R. Swanson, Viktorya Bondarenko, Marina E. Emborg, Valerie Joers, Samuel A. Hurley, Stephan Hermening, Andrew L. Alexander, Sachiko Ohshima-Hosoyama
Publikováno v:
Stereotactic and functional neurosurgery. 92(3)
Background: The efficacy and safety of intracerebral gene therapy for brain disorders like Parkinson's disease depends on the appropriate distribution of gene expression. Objectives: To assess whether the distribution of gene expression is affected b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ebaecbdd4e30cdb72e57c33feb3eb4c
https://pubmed.ncbi.nlm.nih.gov/24943657
https://pubmed.ncbi.nlm.nih.gov/24943657