Výsledky vyhledávání - "Sachiko Ohmori"

Differential expression of cyclin-dependent kinase inhibitors, p27Kip1 and p57Kip2, by corticotropin in rat adrenal cortex

Autor: Toyone Kikumori, Hironobu Kobayashi, Yatsuka Hibi, Fukushi Kambe, Akimasa Nakao, Hisao Seo, Tsuneo Imai, Sachiko Ohmori

Publikováno v: Journal of Endocrinology. 189:671-679

An important role for the cyclin-dependent kinase inhibitors (CDKIs), p27Kip1 and p57Kip2, in the proliferation and differentiation of adrenal cells has been suggested by their knockout mice, which display adrenal hyperplasia. Adrenal development and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3a2fcffdddca0f38b0195a3c6cd62a
https://doi.org/10.1677/joe.1.06419

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DHCR24-Knockout Embryonic Fibroblasts Are Susceptible to Serum Withdrawal-Induced Apoptosis Because of Dysfunction of Caveolae and Insulin-Akt-Bad Signaling

Autor: Hisao Seo, Takahide Kaji, Takehisa Ishii, Xiuli Lu, David Zadworny, Kohji Murakami, Taemi Yoshida, Sachiko Ohmori, Xia Cao, Fukushi Kambe

Publikováno v: Endocrinology. 147:3123-3132

The DHCR24 gene encodes an enzyme catalyzing the last step of cholesterol biosynthesis, the conversion of desmosterol to cholesterol. To elucidate the physiological significance of cholesterol biosynthesis in mammalian cells, we investigated prolifer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa704f6c9c9cb1df00de963c2714399
https://doi.org/10.1210/en.2005-1426

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Glutathionylation of Two Cysteine Residues in Paired Domain Regulates DNABinding Activity ofPax-8

Autor: Xiuli Lu, Hisao Seo, Fukushi Kambe, Natsuko Kobayashi, Xia Cao, Sachiko Ohmori

Publikováno v: Journal of Biological Chemistry. 280:25901-25906

We reported that the first two cysteine residues out of three present in paired domain (PD), a DNA-binding domain, are responsible for redox regulation of Pax-8 DNA binding activity. We show that glutathionylation of these cysteines has a regulatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::751ecf4052e8fd8615e397defdbd9f6c
https://doi.org/10.1074/jbc.m411443200

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Novel human ZAKI-4 isoforms: hormonal and tissue-specific regulation and function as calcineurin inhibitors

Autor: Hisao Seo, Takashi Miyazaki, Sachiko Ohmori, Xia Cao, Devanand Sarkar, Fukushi Kambe

Publikováno v: Biochemical Journal. 367:459-466

We identified a thyroid hormone [3,5,3'-tri-iodothyronine (T(3))]-responsive gene, ZAKI-4, in cultured human skin fibroblasts. It belongs to a family of genes that encode proteins containing a conserved motif. The motif binds to calcineurin and inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d051a242371c0c36cbe4eaddd47abb4d
https://doi.org/10.1042/bj20011797

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Oxidoreductive modification of two cysteine residues in paired domain by Ref-1 regulates DNA-binding activity of Pax-8

Autor: Sachiko Ohmori, Hisao Seo, Fukushi Kambe, Xia Cao

Publikováno v: Biochemical and Biophysical Research Communications. 297:288-293

We have reported reversible oxidoreductive regulation of DNA-binding activity of Pax-8: oxidation inhibits its binding and subsequent reduction restores the binding. Here, we show that Cys-45 and Cys-57 in the paired domain of rat Pax-8, which are co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c91817ebb9ce57145b259560f7f672
https://doi.org/10.1016/s0006-291x(02)02196-4

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The Human Homolog of Diminuto/Dwarf1 Gene (hDiminuto): A Novel ACTH-Responsive Gene Overexpressed in Benign Cortisol-Producing Adrenocortical Adenomas

Autor: Devanand Sarkar, Sachiko Ohmori, Hiroomi Funahashi, Arihiro Shibata, Hisao Seo, Shizu Hayasaka, Fukushi Kambe, Ayesha Siddiq, Tsuneo Imai

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 86:5130-5137

To elucidate the molecular mechanism of the pathogenesis of benign functioning adrenocortical adenomas causing Cushing's syndrome, we employed suppression PCR-based cDNA subtractive hybridization to identify novel genes that are differentially expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d83f36941e4d2d8de284877b612be8
https://doi.org/10.1210/jcem.86.11.8032

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A novel mutation at the donor splice site of intron 3 of the GH-I gene in a patient with isolated growth hormone deficiency

Autor: Takashi Kamijo, Masamichi Ogawa, John A. Phillips, Hisao Seo, Yoshitaka Hayashi, Michiyo Yamamoto, Sachiko Ohmori, Yutaka Igarashi

Publikováno v: Growth Hormone & IGF Research. 9:434-437

A G - C transversion at the fifth nucleotide of intron 3 of GH-I gene was identified in a sporadic case of isolated growth hormone deficiency (IGHD). The mutation was absent in both of the parents, indicating that the mutation occurred de novo. An ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5496eaa41dc154ead649ce6e0649b4be
https://doi.org/10.1054/ghir.1999.0126

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