Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sachiko Kitamoto"'
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 5, Pp n/a-n/a (2021)
Abstract Epyrifenacil is a novel herbicide that acts as an inhibitor of protoporphyrinogen oxidase (PPO) and produces hepatotoxicity in rodents by inhibiting PPO. Our previous research revealed that the causal substance of hepatotoxicity is S‐3100
Externí odkaz:
https://doaj.org/article/7a3eacb68306478f8d36c9eaa9956cf8
Publikováno v:
Journal of Agricultural and Food Chemistry. 69:13190-13199
The metabolic fate of a newly developed herbicide, epyrifenacil, (ethyl[(3-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenoxy}pyridin-2-yl)oxy]acetate, S-3100), in rats was determined using 14C-labeled
Autor:
Miwa Kondo, Ayako Ohara, Brian G. Lake, Hiroyuki Asano, Tomoya Yamada, Yang Liu, Kensuke Kawamoto, Samuel M. Cohen, Kumiko Kobayashi, Takako Fukuda, Sachiko Kitamoto, Keiko Ogata
Publikováno v:
Toxicological Sciences. 184:15-32
Permethrin has been shown to increase lung adenomas in female CD-1 mice, but not in male mice or Wistar rats. The proposed mode of action (MOA) for permethrin-induced female mouse lung tumor formation involves morphological changes in Club cells; inc
Publikováno v:
Toxicology and Applied Pharmacology. 465:116439
Publikováno v:
The Journal of Toxicological Sciences. 46:601-609
Epyrifenacil, one of the protoporphyrinogen oxidase (PPO)-inhibiting herbicides, is hepatotoxic in rodents. Previous in vitro assays detected species differences in both kinetics (active hepatic uptake) and dynamics (PPO inhibitory activity) of S-310
Autor:
Koji Asano, Yasuhiko Takahashi, Manako Ueno, Takako Fukuda, Mitsuhiro Otani, Sachiko Kitamoto, Yoshitaka Tomigahara
Publikováno v:
The Journal of toxicological sciences. 47(4)
Fetal rat anemia from flumioxazin, an N-phenylimide herbicide, is caused by suppression of heme synthesis resulting from inhibition of protoporphyrinogen oxidase (PPO). A series of studies to investigate the effects of flumioxazin have revealed that
Publikováno v:
Toxicology and Applied Pharmacology. 439:115912
Human internal dosimetry of pesticides is essential in the risk assessment when toxicity has been confirmed in laboratory animals. While human toxicokinetics data of pesticides are hardly obtained intendedly, the use of physiologically based pharmaco
Lack of genotoxic potential of permethrin in mice evaluated by the comet assay and micronucleus test
Publikováno v:
Toxicological & Environmental Chemistry. 100:92-102
Permethrin is a common insecticide that does not show genotoxic potential in standard in vitro and in vivo assays. To investigate the genotoxic potential of permethrin in more detail, two in vivo studies were conducted on female mice to assess DNA da
Publikováno v:
Journal of Agricultural & Food Chemistry; 11/10/2021, Vol. 69 Issue 44, p13190-13199, 10p
Autor:
Marlies De Boeck, Dan D. Levy, Marie Vasquez, Kamala Pant, Patricia A. Escobar, Andrew Collins, Günter Speit, Peter Kasper, Carol Beevers, Yoshifumi Uno, Hajime Kojima, Stefan Pfuhler, Jin Tanaka, Ulla Plappert-Helbig, Sachiko Kitamoto, Brian Burlinson
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 783:6-12
As a part of the 6th IWGT, an expert working group on the comet assay evaluated critical topics related to the use of the in vivo comet assay in regulatory genotoxicity testing. The areas covered were: identification of the domain of applicability an