Zobrazeno 1 - 10
of 229
pro vyhledávání: '"Sachiko Kajigaya"'
Autor:
Shouguo Gao, Zhijie Wu, Bradley Arnold, Carrie Diamond, Sai Batchu, Valentina Giudice, Lemlem Alemu, Diego Quinones Raffo, Xingmin Feng, Sachiko Kajigaya, John Barrett, Sawa Ito, Neal S. Young
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
T cell large granular lymphocyte leukemia (T-LGLL) and the cellular phenotype underlying response to therapy is not well understood. Here the authors use single cell sequencing to better understand changes in T cell clonal frequency and gene expressi
Externí odkaz:
https://doaj.org/article/1ce0e22e576f438dbecefabc1c9dfca4
Publikováno v:
BMC Genomics, Vol 21, Iss S11, Pp 1-15 (2020)
Abstract Background Presently, there is no comprehensive analysis of the transcription regulation network in hematopoiesis. Comparison of networks arising from gene co-expression across species can facilitate an understanding of the conservation of f
Externí odkaz:
https://doaj.org/article/db7e8afad6d44868a9c53ab59fb2a036
Autor:
Xin Zhao, Shouguo Gao, Sachiko Kajigaya, Qingguo Liu, Zhijie Wu, Xingmin Feng, Fengkui Zhang, Neal S. Young
Publikováno v:
BMC Research Notes, Vol 13, Iss 1, Pp 1-8 (2020)
Abstract Objective Single cell methodology enables detection and quantification of transcriptional changes and unravelling dynamic aspects of the transcriptional heterogeneity not accessible using bulk sequencing approaches. We have applied single-ce
Externí odkaz:
https://doaj.org/article/aefaea38177245f59eae312766af0c70
Publikováno v:
Genes, Vol 13, Iss 10, p 1890 (2022)
(1) Background: analyses of gene networks can elucidate hematopoietic differentiation from single-cell gene expression data, but most algorithms generate only a single, static network. Because gene interactions change over time, it is biologically me
Externí odkaz:
https://doaj.org/article/1020e5aa01894eddb77f46fb8019ff1f
Publikováno v:
Cancers, Vol 14, Iss 19, p 4957 (2022)
(1) Background: Single-cell RNA sequencing (scRNA-seq) data are useful for decoding cell–cell communication. CellCall is a tool that is used to infer inter- and intracellular communication pathways by integrating paired ligand–receptor (L–R) an
Externí odkaz:
https://doaj.org/article/97d55483ae35428382bfe624386f6966
Autor:
Fernanda Gutierrez-Rodrigues, Isabel Beerman, Emma M. Groarke, Bhavisha A. Patel, Nina Spitofsky, Laura W. Dillon, Diego Quinones Raffo, Christopher S. Hourigan, Sachiko Kajigaya, Luigi Ferrucci, Neal S. Young
Publikováno v:
Haematologica, Vol 107, Iss 8 (2021)
Although cell-free DNA (cfDNA) tests have emerged as a potential non-invasive alternative to bone marrow biopsies for monitoring clonal hematopoiesis in hematologic diseases, whether commercial cfDNA assays can be implemented for the detection and qu
Externí odkaz:
https://doaj.org/article/d21f73a480b347d6bbef0f5a340c1989
Autor:
Alana Vicente, Bhavisha A. Patel, Fernanda Gutierrez-Rodrigues, Emma Groarke, Valentina Giudice, Jennifer Lotter, Xingmin Feng, Sachiko Kajigaya, Barbara Weinstein, Evette Barranta, Matthew J. Olnes, Ankur R. Parikh, Maher Albitar, Colin O. Wu, Ruba Shalhoub, Katherine R. Calvo, Danielle M. Townsley, Phillip Scheinberg, Cynthia E. Dunbar, Neal S. Young, Thomas Winkler
Publikováno v:
Haematologica, Vol 105, Iss 12 (2020)
Myelodysplastic syndromes (MDS) are a group of clonal myeloid disorders characterized by cytopenia and a propensity to develop acute myeloid leukemia (AML). The management of lower-risk (LR) MDS with persistent cytopenias remains suboptimal. Eltrombo
Externí odkaz:
https://doaj.org/article/d39465a6ea80433faa1359329e4d1aed
Autor:
Judith C.W. Marsh, Fernanda Gutierrez-Rodrigues, James Cooper, Jie Jiang, Shreyans Gandhi, Sachiko Kajigaya, Xingmin Feng, Maria del Pilar F. Ibanez, Flávia S. Donaires, João P. Lopes da Silva, Zejuan Li, Soma Das, Maria Ibanez, Alexander E. Smith, Nicholas Lea, Steven Best, Robin Ireland, Austin G. Kulasekararaj, Donal P. McLornan, Anthony Pagliuca, Isabelle Callebaut, Neal S. Young, Rodrigo T. Calado, Danielle M. Townsley, Ghulam J Mufti
Publikováno v:
Blood Advances, Vol 2, Iss 1, Pp 36-48 (2018)
Abstract: Biallelic germline mutations in RTEL1 (regulator of telomere elongation helicase 1) result in pathologic telomere erosion and cause dyskeratosis congenita. However, the role of RTEL1 mutations in other bone marrow failure (BMF) syndromes an
Externí odkaz:
https://doaj.org/article/ed241c993a0c49d0916d090e2dcddf29
Autor:
Fernanda Gutierrez-Rodrigues, Yael Kusne, Jenna Fernandez, Terra L Lasho, Ruba N Shalhoub, Xiaoyang Ma, Hugh Alessi, Christy M. Finke, Matthew J. Koster, Abhishek A. Mangaonkar, Kenneth J Warrington, Kebede Begna, Zhuoer Xie, Amanda K Ombrello, David S Viswanatha, Marcela A. Ferrada, Lorena Wilson, Ronald S. Go, Taxiarchis V. Kourelis, Kaaren K Reichard, Horatiu Olteanu, Ivana Darden, Dalton Hironaka, Lemlem Alemu, Sachiko Kajigaya, Rodrigo T. Calado, Emma M. Groarke, Sofia Rosenzweig, Daniel L Kastner, Katherine R Calvo, Colin O. Wu, Peter C. Grayson, Neal S Young, David B. Beck, Bhavisha A. Patel, Mrinal M. Patnaik
Publikováno v:
Blood Journal.
VEXAS is caused by somatic mutations in UBA1 (UBA1mut) and characterized by heterogenous systemic auto-inflammation and progressive hematologic manifestations, meeting criteria for myelodysplastic syndrome (MDS) and plasma cell dyscrasias. The landsc
Autor:
Shouguo Gao, Zhijie Wu, Jeerthi Kannan, Liza Mathews, Xingmin Feng, Sachiko Kajigaya, Neal S. Young
Publikováno v:
Cells, Vol 10, Iss 5, p 973 (2021)
(1) Background: mouse models are fundamental to the study of hematopoiesis, but comparisons between mouse and human in single cells have been limited in depth. (2) Methods: we constructed a single-cell resolution transcriptomic atlas of hematopoietic
Externí odkaz:
https://doaj.org/article/5a60be72a4c045ef84ece32e036f2535