Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Sachiko I. Blaber"'
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48210 (2012)
Fibroblast growth factor-1 (FGF-1) is an angiogenic factor with therapeutic potential for the treatment of ischemic disease. FGF-1 has low intrinsic thermostability and is characteristically formulated with heparin as a stabilizing agent. Heparin, ho
Externí odkaz:
https://doaj.org/article/9539c4b830f04574a86e2d2c0c5dfa2e
Autor:
Isobel A Scarisbrick, Benjamin Epstein, Beth A Cloud, Hyesook Yoon, Jianmin Wu, Danielle N Renner, Sachiko I Blaber, Michael Blaber, Alexander G Vandell, Alexandra L Bryson
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18376 (2011)
Kallikrein 6 (KLK6) is a newly identified member of the kallikrein family of secreted serine proteases that prior studies indicate is elevated at sites of central nervous system (CNS) inflammation and which shows regulated expression with T cell acti
Externí odkaz:
https://doaj.org/article/cb202fbf74964e07b536e229ae68bf9d
Publikováno v:
Wound Repair and Regeneration. 23:538-549
The development of novel therapies to treat chronic diabetic ulcers depends upon appropriate animal models for early stage investigation. The NONcNZO10/LtJ mouse is a new polygenic strain developed to more realistically model human metabolic syndrome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8058821e8b1e21e570747c828582049b
https://doi.org/10.1111/wrr.12305
https://doi.org/10.1111/wrr.12305
Publikováno v:
Brain Injury. 27:1698-1706
Establishment of a traumatic brain injury (TBI)-sensitive biomarker or identification of a key therapeutic agent would significantly improve clinicians' efforts to diagnose and treat TBI, thereby promoting improved outcomes for patients. Numerous stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e2f51901ee663edef99e9404083d51
https://doi.org/10.3109/02699052.2013.823563
https://doi.org/10.3109/02699052.2013.823563
Autor:
Michael Blaber, Maja Radulovic, Joshua E. Burda, Isobel A. Scarisbrick, Rachel Linbo, Michael G. Fehlings, Jianmin Wu, Nadya Larson, Eleftherios P. Diamandis, Sachiko I. Blaber, Hyesook Yoon
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 72:1072-1089
Kallikreins (KLKs) are a family of 15 secreted serine proteases with emerging roles in neurological disease. To illuminate their contributions to the pathophysiology of spinal cord injury (SCI) we evaluated acute through chronic changes in the immuno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71996d9300c8d42f838480a89fa5dcab
https://doi.org/10.1097/nen.0000000000000007
https://doi.org/10.1097/nen.0000000000000007
Autor:
Robert B. Jenkins, Sachiko I. Blaber, Caterina Giannini, Kristen L. Drucker, Joon H. Uhm, Brian P. O'Neill, Paul A. Decker, Michael Blaber, Alex R. Paulsen, Isobel A. Scarisbrick
Publikováno v:
Neuro-Oncology. 15:305-318
Glioblastoma multiforme (GBM) is classified as World Health Organization (WHO) grade IV astrocytoma and is the most common and malignant form of primary intracranial tumor in adults. GBM patients have an extremely poor prognosis, with a median surviv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ccaecd1283311bc0ae2512c9f46d819
https://doi.org/10.1093/neuonc/nos313
https://doi.org/10.1093/neuonc/nos313
Autor:
Ronald M. Evans, Ozan S. Kumru, Ewa A. Bienkiewicz, Michael Blaber, Xue Xia, Ling Li, Connie A. Tenorio, Annette R. Atkins, Sachiko I. Blaber, Jae Myoung Suh, David M. Ornitz, C. Russell Middaugh, Michael Downes
Publikováno v:
Journal of pharmaceutical sciences. 105(12)
Fibroblast growth factor-1 (FGF-1), a potent human mitogen and insulin sensitizer, signals through both tyrosine kinase receptor-mediated autocrine/paracrine pathways as well as a nuclear intracrine pathway. Phosphorylation of FGF-1 at serine 116 (S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422b1319f359601b91a431e540e26dfd
https://pubmed.ncbi.nlm.nih.gov/27773526
https://pubmed.ncbi.nlm.nih.gov/27773526
Autor:
Michael Blaber, Ozan S. Kumru, C. Russell Middaugh, Mason Sutherland, Xue Xia, Ling Li, Connie A. Tenorio, Sachiko I. Blaber, David M. Ornitz
Human fibroblast growth factor-1 (FGF-1) has broad therapeutic potential in regenerative medicine but has undesirable biophysical properties of low thermostability and 3 buried cysteine (Cys) residues (at positions 16, 83, and 117) that interact to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e4790b88ec3dafe968ba90d9c1d997
https://europepmc.org/articles/PMC5318998/
https://europepmc.org/articles/PMC5318998/
Autor:
Isobel A. Scarisbrick, Maja Radulovic, Sachiko I. Blaber, Alexander G. Vandell, Joshua E. Burda, Caterina Giannini, Michael Blaber, Nadya Larson
Publikováno v:
bchm. 393:355-367
Kallikrein-related peptidase 6 (KLK6) is a trypsin-like serine protease upregulated at sites of central nervous system (CNS) injury, including de novo expression by reactive astrocytes, yet its physiological actions are largely undefined. Taken with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8cbe20c714251b18eb095f9e81b641
https://doi.org/10.1515/hsz-2011-0241
https://doi.org/10.1515/hsz-2011-0241
Autor:
Hyesook Yoon, Michael Panos, Sachiko I. Blaber, Nadya Larson, Isobel A. Scarisbrick, Moses Rodriguez, Michael Blaber
Publikováno v:
Brain Pathology. 22:709-722
Kallikrein 6 (Klk6) is a secreted serine protease that is elevated in active multiple sclerosis lesions and patient sera. To further evaluate the involvement of Klk6 in chronic progressive demyelinating disease, we determined its expression in the br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68e4e5437fe9e591d492a258aa531dce
https://doi.org/10.1111/j.1750-3639.2012.00577.x
https://doi.org/10.1111/j.1750-3639.2012.00577.x