Výsledky vyhledávání - "Sachiko Homma"

Akademický článek

Proximity ligation assay to detect DUX4 protein in FSHD1 muscle: a pilot study

Autor: Mary Lou Beermann, Sachiko Homma, Jeffrey Boone Miller

Publikováno v: BMC Research Notes, Vol 15, Iss 1, Pp 1-6 (2022)

Abstract Objective Aberrant expression in skeletal muscle of DUX4, a double homeobox transcription factor, underlies pathogenesis in facioscapulohumeral muscular dystrophy (FSHD). Although previous studies of FSHD muscle biopsies detected mRNAs encod

Externí odkaz: https://doaj.org/article/239049193c71461b8c3ef4486e2f506e

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Akademický článek

Downstream events initiated by expression of FSHD-associated DUX4: Studies of nucleocytoplasmic transport, γH2AX accumulation, and Bax/Bak-dependence

Autor: Isabel F. Masteika, Anvitha Sathya, Sachiko Homma, Bess M. Miller, Frederick M. Boyce, Jeffrey Boone Miller

Publikováno v: Biology Open, Vol 11, Iss 2, Pp 1-12 (2022)

Abnormal expression in skeletal muscle of the double homeobox transcription factor DUX4 underlies pathogenesis in facioscapulohumeral muscular dystrophy (FSHD). Though multiple changes are known to be initiated by aberrant DUX4 expression, the downst

Externí odkaz: https://doaj.org/article/f7fbab5ef8bf4bfab4d6bff8c99ab42d

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Akademický článek

Nuclear bodies reorganize during myogenesis in vitro and are differentially disrupted by expression of FSHD-associated DUX4

Autor: Sachiko Homma, Mary Lou Beermann, Bryant Yu, Frederick M. Boyce, Jeffrey Boone Miller

Publikováno v: Skeletal Muscle, Vol 6, Iss 1, Pp 1-16 (2016)

Abstract Background Nuclear bodies, such as nucleoli, PML bodies, and SC35 speckles, are dynamic sub-nuclear structures that regulate multiple genetic and epigenetic processes. Additional regulation is provided by RNA/DNA handling proteins, notably T

Externí odkaz: https://doaj.org/article/c68b38002713427695fc4250f8d9c754

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Akademický článek

Functional domains of the FSHD-associated DUX4 protein

Autor: Hiroaki Mitsuhashi, Satoshi Ishimaru, Sachiko Homma, Bryant Yu, Yuki Honma, Mary Lou Beermann, Jeffrey Boone Miller

Publikováno v: Biology Open, Vol 7, Iss 4 (2018)

Aberrant expression of the full-length isoform of DUX4 (DUX4-FL) appears to underlie pathogenesis in facioscapulohumeral muscular dystrophy (FSHD). DUX4-FL is a transcription factor and ectopic expression of DUX4-FL is toxic to most cells. Previous s

Externí odkaz: https://doaj.org/article/32978fad1fc14b22be538ef7551e5072

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