Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Sachiko Hirokawa"'
Autor:
Tomohiko Ishihara, Akihide Koyama, Naoki Atsuta, Mari Tada, Saori Toyoda, Kenta Kashiwagi, Sachiko Hirokawa, Yuya Hatano, Akio Yokoseki, Ryoichi Nakamura, Genki Tohnai, Yuishin Izumi, Ryuji Kaji, Mitsuya Morita, Asako Tamura, Osamu Kano, Masashi Aoki, Satoshi Kuwabara, Akiyoshi Kakita, Gen Sobue, Osamu Onodera
Publikováno v:
BMC Medical Genomics, Vol 17, Iss 1, Pp 1-7 (2024)
Abstract Background The copy number status (CNS) of the survival motor neuron (SMN) gene may influence the risk and prognosis of amyotrophic lateral sclerosis (ALS) and lower motor neuron diseases (LMND) other than spinal muscular atrophy (SMA). Howe
Externí odkaz:
https://doaj.org/article/e6002aa4b2cd48bbb9179f2fb1b1a195
Autor:
Taisuke Kato, Yumi Sekine, Hiroaki Nozaki, Masahiro Uemura, Shoichiro Ando, Sachiko Hirokawa, Osamu Onodera
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
It is increasingly becoming apparent that cerebrovascular dysfunction contributes to the pathogenic processes involved in vascular dementia, Alzheimer’s disease, and other neurodegenerative disorders. Under these pathologic conditions, the degenera
Externí odkaz:
https://doaj.org/article/81a2482bf7ef41e5b05a8045428d3ed3
Publikováno v:
Neurology: Genetics; Jun2023, Vol. 9 Issue 3, p1-7, 7p
Autor:
Hideaki Matsui, Shinji Ito, Hideki Matsui, Junko Ito, Gabdulkhaev, Ramil, Mika Hirose, Tomoyuki Yamanaka, Akihide Koyama, Taisuke Kato, Maiko Tanaka, Norihito Uemura, Noriko Matsui, Sachiko Hirokawa, Maki Yoshihama, Aki Shimozawa, Shin-ichiro Kubo, Kenji Iwasaki, Masato Hasegawa, Ryosuke Takahashi, Keisuke Hirai
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 6/6/2023, Vol. 120 Issue 23, p1-8, 44p
Autor:
Taisuke Kato, Toshiya Sato, Sachiko Hirokawa, Natsumi Fujita, Akihiro Sugai, Yusuke Kawashima, Yasuko Toyoshima, Fuyuki Kametani, Akihide Koyama, Shoji Tsuji, Hironaka Igarashi, Atsushi Sugie, Rie Saito, Masaki Matsumoto, Yuya Hatano, Masaki Fukunaga, Masato Kanazawa, Masato Hasegawa, Osamu Onodera, Hirotoshi Kawata, Ri-Ichiroh Manabe, Shoichiro Ando, Masahiro Uemura, Shigeo Murayama, Satoshi Saito, Masafumi Ihara, Akiyoshi Kakita, Masatoyo Nishizawa, Yumi Sekine, Hiroaki Nozaki
Publikováno v:
J Clin Invest
Cerebral small vessel disease (CSVD) causes dementia and gait disturbance due to arteriopathy. Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a hereditary form of CSVD caused by loss of high-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a139e0c1d46a417b3295090b29c9a18
https://doi.org/10.1172/jci140555
https://doi.org/10.1172/jci140555
Autor:
Sachiko Hirokawa, Yumi Sekine, Masahiro Uemura, Shoichiro Ando, Taisuke Kato, Osamu Onodera, Hiroaki Nozaki
Publikováno v:
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience, Vol 12 (2020)
Frontiers in Aging Neuroscience, Vol 12 (2020)
It is increasingly becoming apparent that cerebrovascular dysfunction contributes to the pathogenic processes involved in vascular dementia, Alzheimer’s disease, and other neurodegenerative disorders. Under these pathologic conditions, the degenera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f25d5e5cc62a7dca7de8f8a988b2893
https://doi.org/10.3389/fnagi.2020.00151
https://doi.org/10.3389/fnagi.2020.00151
Autor:
Sachiko Hirokawa, Yasuko Toyoshima, Hitoshi Takahashi, Akihide Koyama, Masatoyo Nishizawa, Osamu Onodera, Akio Yokoseki, Atsushi Shiga, Akiyoshi Kakita, Tomohiko Ishihara, Misaki Koyama, Takuya Konno, Taisuke Kato, Akihiro Sugai
Publikováno v:
Nucleic Acids Research
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder. In motor neurons of ALS, TAR DNA binding protein-43 (TDP-43), a nuclear protein encoded by TARDBP, is absent from the nucleus and forms cytoplasmic inclusions. TDP-43 auto-regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ba8a627f70644e3032dc354d705480
https://doi.org/10.1093/nar/gkw499
https://doi.org/10.1093/nar/gkw499
Autor:
Hisaaki Namba, Hiroyuki Nawa, T. Kato, Sachiko Hirokawa, Yuichi Abe, Makoto Mizuno, Yuriko Iwakura
Publikováno v:
Current Molecular Medicine
Neuregulin-1 (NRG1) is a well-recognized risk gene for schizophrenia and is often implicated in the neurodevelopmental hypothesis of this illness. Alternative splicing and proteolytic processing of the NRG1 gene produce more than 30 structural varian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c09ef4117df21d720766f4df9a66ae
https://doi.org/10.2174/1566524015666150330143300
https://doi.org/10.2174/1566524015666150330143300
Autor:
Taisuke Kato, Akiyoshi Kakita, Yuichi Abe, Sachiko Hirokawa, Hidekazu Sotoyama, Miwako Ozaki, R Kominami, Hitoshi Takahashi, Hiroyuki Nawa
Publikováno v:
Molecular Psychiatry. 16:307-320
Neuregulin-1 (NRG1) is implicated in the etiology or pathology of schizophrenia, although its biological roles in this illness are not fully understood. Human midbrain dopaminergic neurons highly express NRG1 receptors (ErbB4). To test its neuropatho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b28e99523f68c34860fd23153908ebd
https://doi.org/10.1038/mp.2010.10
https://doi.org/10.1038/mp.2010.10
Autor:
Ishihara, Tomohiko1,2 (AUTHOR) ishihara@bri.niigata-u.ac.jp, Koyama, Akihide3 (AUTHOR), Atsuta, Naoki4 (AUTHOR), Tada, Mari5 (AUTHOR), Toyoda, Saori1 (AUTHOR), Kashiwagi, Kenta1 (AUTHOR), Hirokawa, Sachiko1 (AUTHOR), Hatano, Yuya1 (AUTHOR), Yokoseki, Akio1 (AUTHOR), Nakamura, Ryoichi4 (AUTHOR), Tohnai, Genki6 (AUTHOR), Izumi, Yuishin7 (AUTHOR), Kaji, Ryuji7 (AUTHOR), Morita, Mitsuya8 (AUTHOR), Tamura, Asako9 (AUTHOR), Kano, Osamu10 (AUTHOR), Aoki, Masashi11 (AUTHOR), Kuwabara, Satoshi12 (AUTHOR), Kakita, Akiyoshi5 (AUTHOR), Sobue, Gen6,13 (AUTHOR)
Publikováno v:
BMC Medical Genomics. 11/6/2024, Vol. 17 Issue 1, p1-7. 7p.