Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Sachiko Hirobe"'
Publikováno v:
Clinics and Practice, Vol 14, Iss 2, Pp 377-387 (2024)
Background: Avelumab, durvalumab, and atezolizumab are anti-programmed death-ligand 1 (PD-L1) antibodies approved for clinical application in Japan. Despite targeting the same molecule, avelumab elicits a different frequency of infusion-related react
Externí odkaz:
https://doaj.org/article/97d3072d0a814d10b52acb09e7fcf0db
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1273 (2022)
Chimeric antigen receptor expression T (CAR-T) cell therapy has been shown be efficacious against relapsed/refractory B-cell malignant lymphoma and has attracted attention as an innovative cancer treatment. However, cells of solid tumors are less acc
Externí odkaz:
https://doaj.org/article/d71de1e12fda458c87405d082144892f
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 4056 (2022)
To improve the efficacy and safety of chimeric antigen receptor (CAR)-expressing T cell therapeutics through enhanced CAR design, we analysed CAR structural factors that affect CAR-T cell function. We studied the effects of disulphide bonding at cyst
Externí odkaz:
https://doaj.org/article/42f5ea30e5a340579f8c2175e2fc453d
Autor:
Sachiko Hirobe, Taki Yamasaki, Sayami Ito, Ying-Shu Quan, Fumio Kamiyama, Masashi Tachibana, Naoki Okada
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 385 (2022)
We are interested in promoting the development of transcutaneous immunization using microneedle technology and attempting to apply an adjuvant with transcutaneous immunization to improve the efficacy and reduce the amount of antigen and number of adm
Externí odkaz:
https://doaj.org/article/976aa4da38cb4633a9b2a0669c5e2124
Publikováno v:
Vaccines, Vol 9, Iss 12, p 1480 (2021)
In this study, we investigated the mechanism of transcutaneous adjuvant activity of the CpG-oligonucleotide (K3) in mice. Transcutaneous immunization (TCI) with an ovalbumin-loaded self-dissolving microneedle patch (OVA-sdMN) and K3-loaded hydrophili
Externí odkaz:
https://doaj.org/article/380281181acc4e6394f5451dbaba5e21
Autor:
Sayami Ito, Sachiko Hirobe, Takuto Kawakita, Mio Saito, Ying-Shu Quan, Fumio Kamiyama, Ken J. Ishii, Mizuho Nagao, Takao Fujisawa, Masashi Tachibana, Naoki Okada
Publikováno v:
Pharmaceutics, Vol 12, Iss 3, p 267 (2020)
Transcutaneous immunization (TCI) is easy to use, minimally invasive, and has excellent efficacy in vaccines against infections. We focused on toll-like receptor (TLR) ligands as applicable adjuvants for transcutaneous formulations and characterized
Externí odkaz:
https://doaj.org/article/6e7171d817f94744ab601fe699997f77
Autor:
Akihiko Ono, Sayami Ito, Shun Sakagami, Hideo Asada, Mio Saito, Ying-Shu Quan, Fumio Kamiyama, Sachiko Hirobe, Naoki Okada
Publikováno v:
Pharmaceutics, Vol 9, Iss 4, p 59 (2017)
The authors wish to make a change to their published paper [1].[...]
Externí odkaz:
https://doaj.org/article/a09a2ebeb04f47bd91df0261e1bb12dc
Autor:
Akihiko Ono, Sayami Ito, Shun Sakagami, Hideo Asada, Mio Saito, Ying-Shu Quan, Fumio Kamiyama, Sachiko Hirobe, Naoki Okada
Publikováno v:
Pharmaceutics, Vol 9, Iss 3, p 27 (2017)
Microneedle (MN) patches are promising for transcutaneous vaccination because they enable vaccine antigens to physically penetrate the stratum corneum via low-invasive skin puncturing, and to be effectively delivered to antigen-presenting cells in th
Externí odkaz:
https://doaj.org/article/d4578944afb640dba6b18fb42493c65d
Autor:
Makiko Maeda, Takuya Shintani, Shinichiro Maeda, Wataru Shioyama, Sachiko Hirobe, Yasushi Sakata, Haruka Yokoyama, Yasushi Fujio
Publikováno v:
International Heart Journal. 62:1297-1304
Vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs) frequently induce cardiovascular adverse events, though VEGFR-TKIs contribute to the improvement of the prognosis of patients with malignancies. It is widely accepted
Autor:
Moeno Inukai, Toshiyuki Yokoyama, Rikio Daimon, Nobufumi Matsuura, Ryota Tanaka, Sachiko Hirobe
Publikováno v:
Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences). 47:106-116