Výsledky vyhledávání - "Sachiko Akashi"

Akademický článek

Human RP105 monoclonal antibody enhances antigen-specific antibody production in unique culture conditions

Autor: Tatsuya Yamazaki, Kenta Iwasaki, Susumu Tomono, Masaki Imai, Yuko Miwa, Masato Shizuku, Satoshi Ashimine, Kohei Ishiyama, Masanori Inui, Daisuke Okuzaki, Manabu Okada, Takaaki Kobayashi, Sachiko Akashi-Takamura

Publikováno v: iScience, Vol 27, Iss 9, Pp 110649- (2024)

Summary: Detecting antibodies, particularly those targeting donor human leukocyte antigens in organ transplantation and self-antigens in autoimmune diseases, is crucial for diagnosis and therapy. Radioprotective 105 (RP105), a Toll-like receptor fami

Externí odkaz: https://doaj.org/article/0003be1738c946f7ace852d1cf4559f3

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Akademický článek

IRF3 function and immunological gaps in sepsis

Autor: Bristy Basak, Sachiko Akashi-Takamura

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Lipopolysaccharide (LPS) induces potent cell activation via Toll-like receptor 4/myeloid differentiation protein 2 (TLR4/MD-2), often leading to septic death and cytokine storm. TLR4 signaling is diverted to the classical acute innate immune, inflamm

Externí odkaz: https://doaj.org/article/c918e4d04c154ad899d7d128ba37671b

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Akademický článek

Dietary Supplementation With Eicosapentaenoic Acid Inhibits Plasma Cell Differentiation and Attenuates Lupus Autoimmunity

Autor: Azusa Kobayashi, Ayaka Ito, Ibuki Shirakawa, Atsushi Tamura, Susumu Tomono, Hideo Shindou, Per Niklas Hedde, Miyako Tanaka, Naotake Tsuboi, Takuji Ishimoto, Sachiko Akashi-Takamura, Shoichi Maruyama, Takayoshi Suganami

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Accumulating evidence suggests that cholesterol accumulation in leukocytes is causally associated with the development of autoimmune diseases. However, the mechanism by which fatty acid composition influences autoimmune responses remains unclear. To

Externí odkaz: https://doaj.org/article/15704b94f80744bbb9fe0cc111083c27

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Akademický článek

A Novel Gene Delivery Vector of Agonistic Anti-Radioprotective 105 Expressed on Cell Membranes Shows Adjuvant Effect for DNA Immunization Against Influenza

Autor: Tatsuya Yamazaki, Mrityunjoy Biswas, Kouyu Kosugi, Maria Nagashima, Masanori Inui, Susumu Tomono, Hidekazu Takagi, Isao Ichimonji, Fumiaki Nagaoka, Akira Ainai, Hideki Hasegawa, Joe Chiba, Sachiko Akashi-Takamura

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Radioprotective 105 (RP105) (also termed CD180) is an orphan and unconventional Toll-like receptor (TLR) that lacks an intracellular signaling domain. The agonistic anti-RP105 monoclonal antibody (mAb) can cross-link RP105 on B cells, resulting in th

Externí odkaz: https://doaj.org/article/349c2f98b4804ec392860fc398516433

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Akademický článek

Detection of Urinary Antibodies and Its Application in Epidemiological Studies for Parasitic Diseases

Autor: Fumiaki Nagaoka, Tatsuya Yamazaki, Sachiko Akashi-Takamura, Makoto Itoh

Publikováno v: Vaccines, Vol 9, Iss 7, p 778 (2021)

For epidemiological studies of infectious diseases, pathogen-specific antibody levels in an area give us essential and appropriate information. The antibodies against pathogens are usually detected in blood, the drawing of which inconveniences people

Externí odkaz: https://doaj.org/article/37fa7cfd297f4e63a04cd0f326a1cba6

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Akademický článek

Broadly Neutralizing Antibodies for Influenza: Passive Immunotherapy and Intranasal Vaccination

Autor: Mrityunjoy Biswas, Tatsuya Yamazaki, Joe Chiba, Sachiko Akashi-Takamura

Publikováno v: Vaccines, Vol 8, Iss 3, p 424 (2020)

Influenza viruses cause annual epidemics and occasional pandemics. The high diversity of viral envelope proteins permits viruses to escape host immunity. Therefore, the development of a universal vaccine and broadly neutralizing antibodies (bnAbs) is

Externí odkaz: https://doaj.org/article/3fa276fa3a3542ebb9c1c281a18d782a

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Akademický článek

Neutralizing Antibodies Induced by Gene-Based Hydrodynamic Injection Have a Therapeutic Effect in Lethal Influenza Infection

Autor: Tatsuya Yamazaki, Maria Nagashima, Daisuke Ninomiya, Akira Ainai, Akira Fujimoto, Isao Ichimonji, Hidekazu Takagi, Naoko Morita, Kenta Murotani, Hideki Hasegawa, Joe Chiba, Sachiko Akashi-Takamura

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

The influenza virus causes annual epidemics and occasional pandemics and is thus a major public health problem. Development of vaccines and antiviral drugs is essential for controlling influenza virus infection. We previously demonstrated the use of

Externí odkaz: https://doaj.org/article/cc6286f4ff2b4546ae803b10aebf7e4d

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Akademický článek

Neutralizing Anti-Hemagglutinin Monoclonal Antibodies Induced by Gene-Based Transfer Have Prophylactic and Therapeutic Effects on Influenza Virus Infection

Autor: Tatsuya Yamazaki, Joe Chiba, Sachiko Akashi-Takamura

Publikováno v: Vaccines, Vol 6, Iss 3, p 35 (2018)

Hemagglutinin (HA) of influenza virus is a major target for vaccines. HA initiates the internalization of the virus into the host cell by binding to host sialic acid receptors; therefore, inhibition of HA can significantly prevent influenza virus inf

Externí odkaz: https://doaj.org/article/73299d38a34441b6852465b72ceb1276

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