Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Sachiko, Okabe"'
Autor:
Takahiro Nakamura, Sachiko Okabe, Haruka Yoshida, Keisuke Iida, Yue Ma, Shogo Sasaki, Takao Yamori, Kazuo Shin-ya, Ichiro Nakano, Kazuo Nagasawa, Hiroyuki Seimiya
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract G-quadruplex (G4) is a higher-order nucleic acid structure that is formed by guanine-rich sequences. G4 stabilization by small-molecule compounds called G4 ligands often causes cytotoxicity, although the potential medicinal impact of this ef
Externí odkaz:
https://doaj.org/article/3aa433890e6a4fbf9414876c5f696dba
Autor:
Ichiro Nakano, Hiroyuki Seimiya, Kazuo Shin-ya, Mariano Viapiano, Takao Yamori, Sachiko Okabe, Sarmistha Mazumder, Habibe Demir, Bin Hu, Deepti Purohit, Kaushal Joshi, Yang Pan, Takeshi Miyazaki
PDF file - 1.5MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90247e7275bdcd67b4a87dacfe06ba11
https://doi.org/10.1158/1078-0432.22443585.v1
https://doi.org/10.1158/1078-0432.22443585.v1
Autor:
Ichiro Nakano, Hiroyuki Seimiya, Kazuo Shin-ya, Mariano Viapiano, Takao Yamori, Sachiko Okabe, Sarmistha Mazumder, Habibe Demir, Bin Hu, Deepti Purohit, Kaushal Joshi, Yang Pan, Takeshi Miyazaki
Purpose: Glioma stem cells (GSC) are a critical therapeutic target of glioblastoma multiforme (GBM).Experimental Design: The effects of a G-quadruplex ligand, telomestatin, were evaluated using patient-derived GSCs, non-stem tumor cells (non-GSC), an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d486d713d96b17d1d22f7398f7ea239
https://doi.org/10.1158/1078-0432.c.6519882
https://doi.org/10.1158/1078-0432.c.6519882
Autor:
Hiroyuki Seimiya, Koji Ueda, Sachiko Okabe, Kyoko Matsumoto, Keiji Okamoto, Risa Fujii, Kenichi Ohashi
Publikováno v:
Genes to Cells
G‐quadruplex (G4), a non‐canonical higher‐order structure formed by guanine‐rich nucleic acid sequences, affects various genetic events in cis, including replication, transcription and translation. Whereas up‐regulation of innate immune/int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54334d92258e1b3ba6dfcbe2f7a84022
https://doi.org/10.1111/gtc.12824
https://doi.org/10.1111/gtc.12824
Autor:
Young-Tae Chang, Yuki Wakabayashi, Kazuo Nagasawa, Yue Ma, Hiroyuki Seimiya, Sachiko Okabe, Dongdong Su, Mizuho Yasuda, Masayuki Tera
Publikováno v:
Chemical communications (Cambridge, England). 56(85)
Macrocyclic hexaoxazoles (6OTDs) are G-quadruplex (G4) ligands, and some derivatives, such as L2H2-6OTD (1a) bearing two aminobutyl side chains, show cytotoxicity towards cancer cells. To identify the cellular target of 1a, we employed a post-target-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ea5868f23d6702801bb86c3af295ed
https://pubmed.ncbi.nlm.nih.gov/33030187
https://pubmed.ncbi.nlm.nih.gov/33030187
Autor:
Yue Ma, Shogo Sasaki, Yamato Tsushima, Mai Sakuma, Sachiko Okabe, Kazuo Nagasawa, Takatsugu Hirokawa, Keisuke Iida, Hiroyuki Seimiya
Publikováno v:
Organic & Biomolecular Chemistry. 16:7375-7382
G-Quadruplex structures (G4s) in guanine-rich regions of DNA play critical roles in various biological phenomena, including replication, translation, and gene expression. The G4-forming DNAs can form three kinds of topologies, i.e., parallel, anti-pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08e33feae448879cefd64d30da11215
https://doi.org/10.1039/c8ob01702f
https://doi.org/10.1039/c8ob01702f
Autor:
Kazuo Shin-ya, Sachiko Okabe, Keisuke Iida, Haruka Yoshida, Kazuo Nagasawa, Ichiro Nakano, Yue Ma, Takahiro Nakamura, Takao Yamori, Shogo Sasaki, Hiroyuki Seimiya
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports
Scientific Reports
G-quadruplex (G4) is a higher-order nucleic acid structure that is formed by guanine-rich sequences. G4 stabilization by small-molecule compounds called G4 ligands often causes cytotoxicity, although the potential medicinal impact of this effect has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ae1a017d67c9511bd2399ba065d970
https://doaj.org/article/3aa433890e6a4fbf9414876c5f696dba
https://doaj.org/article/3aa433890e6a4fbf9414876c5f696dba
Autor:
Kyoko Matsumoto, Keiji Okamoto, Sachiko Okabe, Risa Fujii, Koji Ueda, Kenichi Ohashi, Hiroyuki Seimiya
Publikováno v:
Genes to Cells; Feb2021, Vol. 26 Issue 2, p65-82, 18p
Autor:
Saori Igarashi, Kazutaka Ikeda, Toshiro Migita, Akihiro Tomida, Hiroyuki Seimiya, Tomoyoshi Soga, Sachiko Okabe, Ryo Taguchi, Shoko Sugawara
Publikováno v:
International Journal of Cancer. 135:37-47
De novo lipogenesis is activated in most cancers and several lipogenic enzymes have been implicated as therapeutic targets. Here, we demonstrate a novel function of the lipogenic enzyme, ATP citrate lyase (ACLY), in lipid metabolism in cancer cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd332f1c5184eb207ca71cc494d05ca
https://doi.org/10.1002/ijc.28652
https://doi.org/10.1002/ijc.28652
Autor:
Toshiro Migita, Shoko Sugawara, Sachiko Okabe, Akihiro Tomida, Kazutaka Ikeda, Hiroyuki Seimiya, Tomoyoshi Soga, Ryo Taguchi, Saori Igarashi
Publikováno v:
The American Journal of Pathology. 182:1800-1810
De novo lipogenesis is activated in most cancers. Inhibition of ATP citrate lyase (ACLY), the enzyme that catalyzes the first step of de novo lipogenesis, leads to growth suppression and apoptosis in a subset of human cancer cells. Herein, we found t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe7e1b66eec236e4fa7923a15cbcbe43
https://doi.org/10.1016/j.ajpath.2013.01.048
https://doi.org/10.1016/j.ajpath.2013.01.048