Zobrazeno 1 - 10
of 414
pro vyhledávání: '"Sachdev S. Sidhu"'
Autor:
Evan Sawula, Shane Miersch, Eric D. Jong, Chengjin Li, Fang-Yu Chou, Jean Kit Tang, Reza Saberianfar, Jeffrey Harding, Sachdev S. Sidhu, Andras Nagy
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Background Immunologically impaired individuals respond poorly to vaccines, highlighting the need for additional strategies to protect these vulnerable populations from COVID-19. While monoclonal antibodies (mAbs) have emerged as promising t
Externí odkaz:
https://doaj.org/article/e59caee950d2466e9ef888001b73da51
Autor:
Edmond M. Linossi, Kunlun Li, Gianluca Veggiani, Cyrus Tan, Farhad Dehkhoda, Colin Hockings, Dale J. Calleja, Narelle Keating, Rebecca Feltham, Andrew J. Brooks, Shawn S. Li, Sachdev S. Sidhu, Jeffrey J. Babon, Nadia J. Kershaw, Sandra E. Nicholson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/3771a83e093b48e7a5c69cac8e14f288
Autor:
Abdulkhaliq Alsaadi, Mara Artibani, Zhiyuan Hu, Nina Wietek, Matteo Morotti, Laura Santana Gonzalez, Moiad Alazzam, Jason Jiang, Beena Abdul, Hooman Soleymani majd, Levi L. Blazer, Jarret Adams, Francesca Silvestri, Sachdev S. Sidhu, Joan S. Brugge, Ahmed Ashour Ahmed
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113354- (2023)
Summary: The study of fallopian tube (FT) function in health and disease has been hampered by limited knowledge of FT stem cells and lack of in vitro models of stem cell renewal and differentiation. Using optimized organoid culture conditions to addr
Externí odkaz:
https://doaj.org/article/b3b9c8430ef84ea8bc3a229beaff06ed
Autor:
Bruno Brandimarte, Lino Di Rienzo Businco, Francesco Cappello, Roberto Fiore, Giuseppe Bastone, Gianfranco Gualdi, Saadi Sollaku, Emanuele Casciani, Federica Tortorella, Pasquale Longo, Eleonora Centanini, Silva Pavaci, Federica Sangiuolo, Maria Patrizia Patrizi, Shane Miersch, Sachdev S. Sidhu, Virgilio Sacchini, Giuseppe Novelli
Publikováno v:
Heliyon, Vol 9, Iss 3, Pp e14673- (2023)
The currently available nebulization devices have a slow aerosol flow and produce vapor with large microdrops. Improved devices that achieve higher airflow and produce smaller microdrops are needed to improve the clinical care of patients. To address
Externí odkaz:
https://doaj.org/article/4248c3c0213140f6bdde19ef5796b8c1
Autor:
Edmond M. Linossi, Kunlun Li, Gianluca Veggiani, Cyrus Tan, Farhad Dehkhoda, Colin Hockings, Dale J. Calleja, Narelle Keating, Rebecca Feltham, Andrew J. Brooks, Shawn S. Li, Sachdev S. Sidhu, Jeffrey J. Babon, Nadia J. Kershaw, Sandra E. Nicholson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Abstract Suppressor of cytokine signaling (SOCS)2 protein is a key negative regulator of the growth hormone (GH) and Janus kinase (JAK)-Signal Transducers and Activators of Transcription (STAT) signaling cascade. The central SOCS2-Src homology 2 (SH2
Externí odkaz:
https://doaj.org/article/c6fcc1c1f3344e70a63c5dfee1ef2786
Autor:
Nawneet Mishra, Joan Teyra, RuthMabel Boytz, Shane Miersch, Trudy N. Merritt, Lia Cardarelli, Maryna Gorelik, Filip Mihalic, Per Jemth, Robert A. Davey, Sachdev S. Sidhu, Daisy W. Leung, Gaya K. Amarasinghe
Publikováno v:
Data in Brief, Vol 43, Iss , Pp 108415- (2022)
SARS-CoV-2 pandemic opens up the curiosity of understanding the coronavirus. This demand for the development of the regent, which can be used for academic and therapeutic applications. The present data provide the biochemical characterization of synt
Externí odkaz:
https://doaj.org/article/a822c6ddef5d40eb9aa0c6caef9c9b2d
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Kelil, Gallo et al. develop an antibody discovery strategy, termed CellectSeq, for targeting integral membrane proteins on native cells. This strategy uses motif-based scoring and sequencing error-filtering algorithms to identify antibodies with high
Externí odkaz:
https://doaj.org/article/45934952be24446d877a084a048a5f19
Autor:
Giuseppe Novelli, Jing Liu, Michela Biancolella, Tonino Alonzi, Antonio Novelli, J. J. Patten, Dario Cocciadiferro, Emanuele Agolini, Vito Luigi Colona, Barbara Rizzacasa, Rosalinda Giannini, Benedetta Bigio, Delia Goletti, Maria Rosaria Capobianchi, Sandro Grelli, Justin Mann, Trevor D. McKee, Ke Cheng, Fatima Amanat, Florian Krammer, Andrea Guarracino, Gerardo Pepe, Carlo Tomino, Yacine Tandjaoui-Lambiotte, Yurdagul Uzunhan, Sarah Tubiana, Jade Ghosn, COVID Human Genetic Effort, French COVID Cohort Study Group, CoV-Contact Cohort, Luigi D. Notarangelo, Helen C. Su, Laurent Abel, Aurélie Cobat, Gai Elhanan, Joseph J. Grzymski, Andrea Latini, Sachdev S. Sidhu, Suresh Jain, Robert A. Davey, Jean-Laurent Casanova, Wenyi Wei, Pier Paolo Pandolfi
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-18 (2021)
Abstract SARS-CoV-2 is responsible for the ongoing world-wide pandemic which has already taken more than two million lives. Effective treatments are urgently needed. The enzymatic activity of the HECT-E3 ligase family members has been implicated in t
Externí odkaz:
https://doaj.org/article/44bb55f6f8b74b5bb5433d1a15eac416
Autor:
Chiara Nardin, Abraham Tettey-Matey, Viola Donati, Daniela Marazziti, Chiara Di Pietro, Chiara Peres, Marcello Raspa, Francesco Zonta, Guang Yang, Maryna Gorelik, Serena Singh, Lia Cardarelli, Sachdev S. Sidhu, Fabio Mammano
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7337 (2022)
Connexin (Cx) hemichannels (HCs) are large pore hexameric structures that allow the exchange of ions, metabolites and a variety of other molecules between the cell cytoplasm and extracellular milieu. HC inhibitors are attracting growing interest as d
Externí odkaz:
https://doaj.org/article/b9a9efb8a033401c94fada337ca202ee
Autor:
Leonie Enderle, Karim H. Shalaby, Maryna Gorelik, Alexander Weiss, Levi L. Blazer, Marcin Paduch, Lia Cardarelli, Anthony Kossiakoff, Jarrett J. Adams, Sachdev S. Sidhu
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
In order to direct T cells to specific features of solid cancer cells, we engineered a bispecific antibody format, named Dual Antigen T cell Engager (DATE), by fusing a single-chain variable fragment targeting CD3 to a tumor-targeting antigen-binding
Externí odkaz:
https://doaj.org/article/777c600eb1a04893b2cef9f6918ac3c1