Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Sacha Ninkovic"'
Publikováno v:
Acta Crystallographica Section E, Vol 66, Iss 8, Pp o2021-o2021 (2010)
The crystal structure of the title compound, C5H3BrN2S, shows that bromination of 1H-thieno[2,3-d]imidazole with N-bromosuccinimide in acetonitrile occurs at position 5 of the bicyclic system. The molecule is almost planar, with a mean deviation of 0
Externí odkaz:
https://doaj.org/article/09da7bb081cb4e3f938fec3837b07306
Autor:
Kenna Anderes, Patrick O'Connor, Tim Nichols, Ping Chen, Sacha Ninkovic, Stephan Grant, James Register, Eugenia Kraynov, Maria Elena Arango, Enhong Chen, Jill Hallin, Alessandra Blasina
Supplementary Material from Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a1ddf5efb05d35cd25b7aeeec0e653
https://doi.org/10.1158/1535-7163.22483773
https://doi.org/10.1158/1535-7163.22483773
Autor:
Kenna Anderes, Patrick O'Connor, Tim Nichols, Ping Chen, Sacha Ninkovic, Stephan Grant, James Register, Eugenia Kraynov, Maria Elena Arango, Enhong Chen, Jill Hallin, Alessandra Blasina
Checkpoints are present in all phases of the cell cycle and are regarded as the gatekeepers maintaining the integrity of the genome. Many conventional agents used to treat cancer impart damage to the genome and activate cell cycle checkpoints. Many t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c7538561a2baaeadc83807bbcb1eab7
https://doi.org/10.1158/1535-7163.c.6531231.v1
https://doi.org/10.1158/1535-7163.c.6531231.v1
Autor:
Kephart Susan Elizabeth, Tran Khanh Tuan, Kevin Daniel Freeman-Cook, Sherry Niessen, James Solowiej, Buwen Huang, Qin Zhang, Douglas Carl Behenna, Inish O'Doherty, Sacha Ninkovic, Rose Ann Ferre, Andrea Hui, Nichol Miller, Jordan Carelli, Lisa Nguyen, Brion W. Murray, Robert Louis Hoffman, John Lapek, Rhys M. Jones, Meirong Xu, Stephen Dann, Sutton Scott Channing, Asako Nagata, Nanni Huser, Ravi Visswanathan, Zehnder Luke Raymond, Elaine E. Tseng, Britton Boras, You-Ai He, Michele McTigue, Wade Diehl, Cathy Zhang, Martha A. Ornelas
Publikováno v:
Journal of medicinal chemistry. 64(13)
Control of the cell cycle through selective pharmacological inhibition of CDK4/6 has proven beneficial in the treatment of breast cancer. Extending this level of control to additional cell cycle CDK isoforms represents an opportunity to expand to add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8850d384322d3198a875fe9a0d1ad8ea
https://pubmed.ncbi.nlm.nih.gov/34110834
https://pubmed.ncbi.nlm.nih.gov/34110834
Autor:
Meirong Xu, Koleen Eisele, Douglas Carl Behenna, John Chionis, Sutton Scott Channing, Cathy Zhang, Ping Wei, Ravi Visswanathan, Stephen Dann, B Jessen, Robert M. Hoffman, Britton Boras, Kevin Daniel Freeman-Cook, Michael A. White, Qin Zhang, Brion W. Murray, Jing Yuan, Sacha Ninkovic, Scott L. Weinrich, Nanni Huser, Jim Solowiej, Nichol Miller, Todd VanArsdale, Chaoting Liu
Publikováno v:
Cancer Research. 79:P6-20
This abstract was withdrawn by the authors. Citation Format: Dann S, Chionis J, Eisele K, Zhang Q, Liu C, Yuan J, Miller N, Murray B, Xu M, Solowiej J, Wei P, Weinrich S, Sutton S, Behenna D, Ninkovic S, Hoffman R, Freeman-Cook K, Jessen B, Huser N,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b19138b5c3ef7573b036666a0301a9f
https://doi.org/10.1158/1538-7445.sabcs18-p6-20-06
https://doi.org/10.1158/1538-7445.sabcs18-p6-20-06
Autor:
Xinmeng Jasmine Mu, Meirong Xu, Shahram Salek-Ardakani, Cinthia Costa-Jones, Lisa Nguyen, James Solowiej, David Looper, Scott L. Weinrich, Robert Louis Hoffman, Sutton Scott Channing, Sacha Ninkovic, Kephart Susan Elizabeth, Sherry Niessen, John Chionis, Jadwiga Bienkowska, Kevin Daniel Freeman-Cook, Rose Ann Ferre, John Lapek, Cecilia Oderup, Jordan Carelli, Cathy Zhang, Nanni Huser, Elizabeth A. McMillan, Asako Nagata, Martha A. Ornelas, Brion W. Murray, Douglas Carl Behenna, Koleen Eisele, Todd VanArsdale, Zhou Zhu, Zhengyan Kan, Chaoting Liu, Nichol Miller, Zehnder Luke Raymond, Michael A. White, Ying Ding, Nathan V. Lee, Jonathan Almaden, Qin Zhang, Tran Khanh Tuan, Ping Wei, Stephen Dann, Britton Boras, Tim S. Wang, Ravi Visswanathan, You-Ai He, Michele McTigue, Elizabeth Wilson
Publikováno v:
Cancer Cell. 39:1404-1421.e11
Summary The CDK4/6 inhibitor, palbociclib (PAL), significantly improves progression-free survival in HR+/HER2− breast cancer when combined with anti-hormonals. We sought to discover PAL resistance mechanisms in preclinical models and through analys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed89e2bd873344dd19ed1d4ed19277ab
https://doi.org/10.1016/j.ccell.2021.08.009
https://doi.org/10.1016/j.ccell.2021.08.009
Autor:
Michelle Tran-Dubé, Bruce M. Bechle, Michelle Kraus, Ciarán N. Cronin, Kim James, Joseph S. Warmus, Fen Wang, Jianmin Sun, Indrawan James Mcalpine, Sacha Ninkovic, Jianwei Bian, Samantha Elizabeth Greasley, Neil J. Flanagan, Matthew Corbett, Rebecca Dias, Andrews Mark David, Asako Nagata, John F. Braganza, Linda Kitching, David C. Blakemore, Eric Johnson, Sarah Elizabeth Skerratt, Kiyoyuki Omoto, Sharan K. Bagal, Jingrong Jean Cui, James Bilsland, Peter J. Bungay, Rachel L. Grimley, Stephanie Scales, Gareth Waldron
Publikováno v:
Journal of medicinal chemistry. 61(15)
Hormones of the neurotrophin family, nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4 (NT4), are known to activate the family of Tropomyosin receptor kinases (TrkA, TrkB, and TrkC). Moreove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f470c72f1e1c68f507f99de2c39e1f77
https://pubmed.ncbi.nlm.nih.gov/29944371
https://pubmed.ncbi.nlm.nih.gov/29944371
Autor:
Michael R. Collins, Louise Bernier, Michelle Tran-Dubé, Botrous Iriny, Shijian Ren, Qingbin Zeng, Sacha Ninkovic, Neal W. Sach, John F. Braganza, Baojiang Zheng, Indrawan James Mcalpine, Baohua Li
Publikováno v:
Tetrahedron Letters. 56:5757-5760
An efficient synthesis of 6-substituted-pyrazolo[1,5- a ]pyridines via an intramolecular cyclization of 1-amino-2-triethyl-silanylethynyl-pyridinium salts has been developed. The cyclization reaction proceeds in the presence of catalytic silver(I) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cbad167ae1f041ec665ea820bb4f4ce
https://doi.org/10.1016/j.tetlet.2015.08.050
https://doi.org/10.1016/j.tetlet.2015.08.050
Autor:
Paul G. Richardson, Phuong Le, Benjamin J. Burke, Ted William Johnson, Sacha Ninkovic, Ketan S. Gajiwala, Maria Angelica Linton
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:3408-3413
Incorporation of nitrogen is a common medicinal chemistry tactic to reduce log D values. Neighboring group participation influences log D , so the results are isomer dependent. The log D and log P differences observed between isomeric pyrimidines 1 ,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658c49747fb24d27934733c69e9c1fce
https://doi.org/10.1016/j.bmc.2015.04.041
https://doi.org/10.1016/j.bmc.2015.04.041
Autor:
Sacha Ninkovic, Stephanie Scales, Fen Wang, Sarah Johnson, Michelle Tran-Dubé, Indrawan James Mcalpine
Publikováno v:
Tetrahedron Letters. 54:4054-4057
A mild two-step one-pot procedure for the conversion of ortho-nitroamino aromatic heterocycles into corresponding benzo and heteroaromatic fused imidazoles is described. The procedure utilizes iron powder, acetic acid, triethylorthoformate, and a cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a69048d3ae39fdd04836b11fbc16c2e5
https://doi.org/10.1016/j.tetlet.2013.05.092
https://doi.org/10.1016/j.tetlet.2013.05.092