Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sacha Kassovska-Bratinova"'
Autor:
Ionel Sandovici, Sacha Kassovska-Bratinova, Joe E Vaughan, Rae Stewart, Mark Leppert, Carmen Sapienza
Publikováno v:
PLoS Genetics, Vol 2, Iss 7, p e101 (2006)
Human recombination rates vary along the chromosomes as well as between the two sexes. There is growing evidence that epigenetic factors may have an important influence on recombination rates, as well as on crossover position. Using both public datab
Externí odkaz:
https://doaj.org/article/b59eacf0b3d34f77a9367a1bc07586f4
Autor:
Kevin Sullivan, Harvey Rubin, Jeffrey D. Winkler, Takahiro Yano, J. Shin Teh, Sacha Kassovska-Bratinova, Norman M. Schechter, André K. Isaacs
Publikováno v:
Journal of Biological Chemistry. 286:10276-10287
The mechanism of action of clofazimine (CFZ), an antimycobacterial drug with a long history, is not well understood. The present study describes a redox cycling pathway that involves the enzymatic reduction of CFZ by NDH-2, the primary respiratory ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65374e0cd7f634673d453d676a26195c
https://doi.org/10.1074/jbc.m110.200501
https://doi.org/10.1074/jbc.m110.200501
Publikováno v:
Pediatric Research. 65:145-149
Heme oxygenase-1 (HO-1), the rate-limiting enzyme of heme degradation and antioxidant defense protein, is induced in the lungs of animals exposed to hyperoxia. However, high levels of HO-1 expression may be deleterious, thus necessitating tight regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136ffadc9241eb8912cf553b1ca13512
https://doi.org/10.1203/pdr.0b013e318191eedc
https://doi.org/10.1203/pdr.0b013e318191eedc
Autor:
Haruki Nakamura, Ronald J.A. Wanders, Naomi Kondo, Sacha Kassovska-Bratinova, Grant A. Mitchell, G. T. N. Besley, Kenji E. Orii, Toshiyuki Fukao, K. E. Niezen-Koning, James E. Wraith, Gerard T. Berry, Xiang-Qian Song, Michael J. Palmieri
Publikováno v:
Genomics, 68(2), 144-151. Academic Press Inc.
GENOMICS, 68(2), 144-151. ACADEMIC PRESS INC ELSEVIER SCIENCE
GENOMICS, 68(2), 144-151. ACADEMIC PRESS INC ELSEVIER SCIENCE
The activity of succinyl-CoA:3-ketoacid CoA transferase (SCOT; locus symbol OXCT; EC 2.8.3.5) is the main determinant of the ketolytic capacity of tissues. Hereditary SCOT deficiency causes episodic ketoacidosis. Here we describe the human SCOT gene,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c8ccc50e57e3a2dd4e66723d97046f
https://doi.org/10.1006/geno.2000.6282
https://doi.org/10.1006/geno.2000.6282
Autor:
Toshiyuki Fukao, Ronald J.A. Wanders, Naomi Kondo, Sacha Kassovska-Bratinova, Haruo Shintaku, Ken Hirayama, Xiang-Qian Song, Tadao Orii, Grant A. Mitchell, Magdalena Ugarte, Perry Churchill, Hiroh Watanabe
Publikováno v:
Biochimica et Biophysica Acta, 1360, 151-156
Succinyl-CoA:3-ketoacid CoA transferase (SCOT) is a key enzyme for ketone body utilization. Hereditary SCOT deficiency in humans (McKusick catalogue number 245050) is characterized by intermittent ketoacidotic attacks and permanent hyperketonemia. Si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f6597257f77f8c3676429ee17e8d37
Publikováno v:
The FASEB Journal. 21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35edb417abe8cf1be94bbb89d8157637
https://doi.org/10.1096/fasebj.21.6.a1143-d
https://doi.org/10.1096/fasebj.21.6.a1143-d
Autor:
Mark Leppert, F. Dale Bautista, Michael Schiraldi, Sacha Kassovska-Bratinova, Ionel Sandovici, J. Concepción Loredo-Osti, Alexander Suarez, Rae Stewart, Carmen Sapienza
Publikováno v:
Human molecular genetics. 14(15)
We investigated the CpG methylation of 19 specific members of Alu sub-families in human DNA isolated from whole blood, using an assay based on methylation-sensitive restriction endonuclease digestion of genomic DNA and 'hot-stop' polymerase chain rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0652b1f39d4822f7e9f04a695d861c6
https://pubmed.ncbi.nlm.nih.gov/15972727
https://pubmed.ncbi.nlm.nih.gov/15972727
Autor:
Jacqueline M. Bourgeois, Sandeep Raha, Gillian McEachern, Brian H. Robinson, Sacha Kassovska-Bratinova, Mark A. Tarnopolsky, John Turnbull
Publikováno v:
Biochemical and biophysical research communications. 273(1)
The most frequent genetic causes of amyotrophic lateral sclerosis (ALS) determined so far are mutations occurring in the gene for copper/zinc superoxide dismutase (CuZnSOD). The mechanism may involve inappropriate formation of hyroxyl radicals, perox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5608163d4c122a3a6ded07697dcd6b
https://pubmed.ncbi.nlm.nih.gov/10873611
https://pubmed.ncbi.nlm.nih.gov/10873611
Autor:
Grant A. Mitchell, Toshiyuki Fukao, Naomi Kondo, Sacha Kassovska-Bratinova, Ken Hirayama, Xiang-Qian Song, Hiroh Watanabe, Haruo Shintaku
Publikováno v:
Human mutation. 12(2)
Succinyl-CoA:3-ketoacid CoA transferase (SCOT; EC 2.8.3.5; locus symbol OXCT) is the key enzyme of ketone body utilization. Hereditary SCOT deficiency (MIM 245050) causes episodes of severe ketoacidosis. We developed a transient expression system for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba24682f28c98ca33608beaab201a85
https://pubmed.ncbi.nlm.nih.gov/9671268
https://pubmed.ncbi.nlm.nih.gov/9671268
Previous studies suggest oxygen free radicals' involvement in the etiology of cardiomyopathy with cataracts. To investigate the role of free radicals in the pathogenesis of the cardiomyopathy with cataracts and complex I deficiency, fibroblasts from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388af7563bc86feb569f39fa3803aed1
https://europepmc.org/articles/PMC508138/
https://europepmc.org/articles/PMC508138/
