Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Sacha Genovesi"'
Autor:
Alessandro Alaimo, Marco Lorenzoni, Paolo Ambrosino, Arianna Bertossi, Alessandra Bisio, Alice Macchia, Eugenio Zoni, Sacha Genovesi, Francesco Cambuli, Veronica Foletto, Dario De Felice, Maria Virginia Soldovieri, Ilaria Mosca, Francesco Gandolfi, Matteo Brunelli, Gianluca Petris, Anna Cereseto, Alvaro Villarroel, George Thalmann, Francesco Giuseppe Carbone, Marianna Kruithof-de Julio, Mattia Barbareschi, Alessandro Romanel, Maurizio Taglialatela, Andrea Lunardi
Publikováno v:
Cell Death and Disease, Vol 11, Iss 12, Pp 1-17 (2020)
Abstract Therapy resistance is a major roadblock in oncology. Exacerbation of molecular dysfunctions typical of cancer cells have proven effective in twisting oncogenic mechanisms to lethal conditions, thus offering new therapeutic avenues for cancer
Externí odkaz:
https://doaj.org/article/df6bf34ea7084a21b91211d2e2dccd09
Autor:
Sacha Genovesi, Riccardo Moro, Beatrice Vignoli, Dario De Felice, Marco Canossa, Rodolfo Montironi, Francesco Giuseppe Carbone, Mattia Barbareschi, Andrea Lunardi, Alessandro Alaimo
Publikováno v:
Biomolecules, Vol 12, Iss 2, p 193 (2022)
Metastatic prostate cancer (mPCa) is one of the leading causes of cancer-related mortality in both the US and Europe. Androgen deprivation is the first-line therapy for mPCa; however, resistance to therapy inevitably occurs and the disease progresses
Externí odkaz:
https://doaj.org/article/b211766aceb14f37b31fab83e1fb4cac
Autor:
Francesco Andreatta, Giulia Beccaceci, Nicolò Fortuna, Martina Celotti, Dario De Felice, Marco Lorenzoni, Veronica Foletto, Sacha Genovesi, Josep Rubert, Alessandro Alaimo
Publikováno v:
Cancers, Vol 12, Iss 11, p 3303 (2020)
Glioblastoma (GB) is the most frequent and aggressive type of glioma. The lack of reliable GB models, together with its considerable clinical heterogeneity, has impaired a comprehensive investigation of the mechanisms that lead to tumorigenesis, canc
Externí odkaz:
https://doaj.org/article/f3bd5354bec3435894fc7c8470a00112
Autor:
David Westaway, Sacha Genovesi, Nathalie Daude, Rebecca Brown, Agnes Lau, Inyoul Lee, Charles E Mays, Janaky Coomaraswamy, Brenda Canine, Rose Pitstick, Allen Herbst, Jing Yang, Kerry W S Ko, Gerold Schmitt-Ulms, Stephen J Dearmond, Debbie McKenzie, Leroy Hood, George A Carlson
Publikováno v:
PLoS Pathogens, Vol 7, Iss 11, p e1002391 (2011)
During prion infections of the central nervous system (CNS) the cellular prion protein, PrP(C), is templated to a conformationally distinct form, PrP(Sc). Recent studies have demonstrated that the Sprn gene encodes a GPI-linked glycoprotein Shadoo (S
Externí odkaz:
https://doaj.org/article/e584a8d43c0742d5a8d9a9a1c72ee629
Autor:
Sacha Genovesi, Liviana Leita, Paolo Sequi, Igino Andrighetto, M Catia Sorgato, Alessandro Bertoli
Publikováno v:
PLoS ONE, Vol 2, Iss 10, p e1069 (2007)
Scrapie and chronic wasting disease are contagious prion diseases affecting sheep and cervids, respectively. Studies have indicated that horizontal transmission is important in sustaining these epidemics, and that environmental contamination plays an
Externí odkaz:
https://doaj.org/article/3dfe393f1a1c447fb7a7b1a391ac74da
Publikováno v:
Oncoscience
The therapeutic landscape of cancer treatments is quickly evolving thanks to the advent of precision oncology. Discovery of novel druggable targets and more reliable biomarkers is a primary objective towards personalized strategies of cancer treatmen
Autor:
Francesco Cambuli, Veronica Foletto, Alessandro Alaimo, Dario De Felice, Francesco Gandolfi, Maria Dilia Palumbieri, Michela Zaffagni, Sacha Genovesi, Marco Lorenzoni, Martina Celotti, Emiliana Bertossio, Giosuè Mazzero, Arianna Bertossi, Alessandra Bisio, Francesco Berardinelli, Antonio Antoccia, Marco Gaspari, Mattia Barbareschi, Michelangelo Fiorentino, Michael M Shen, Massimo Loda, Alessandro Romanel, Andrea Lunardi
Publikováno v:
EMBO reports. 23(5)
The healthy prostate is a relatively quiescent tissue. Yet, prostate epithelium overgrowth is a common condition during aging, associated with urinary dysfunction and tumorigenesis. For over thirty years, TGF-β ligands have been known to induce cyto
Autor:
Marco Lorenzoni, Josep Rubert, Sacha Genovesi, Francesco Andreatta, Alessandro Alaimo, Dario De Felice, Giulia Beccaceci, Nicolò Fortuna, Martina Celotti, Veronica Foletto
Publikováno v:
Cancers
Cancers 12 (2020) 11
Cancers, 12(11), 1-16
Cancers, Vol 12, Iss 3303, p 3303 (2020)
Cancers 12 (2020) 11
Cancers, 12(11), 1-16
Cancers, Vol 12, Iss 3303, p 3303 (2020)
Simple Summary Glioblastoma is the most lethal primary adult brain tumor. The great number of mutations involved and the aggressiveness of glioblastoma render this type of cancer especially difficult to investigate. To address this problem, cerebral
Autor:
Sacha Genovesi, Riccardo Moro, Beatrice Vignoli, Dario De Felice, Marco Canossa, Rodolfo Montironi, Francesco Giuseppe Carbone, Mattia Barbareschi, Andrea Lunardi, Alessandro Alaimo
Publikováno v:
Biomolecules; Volume 12; Issue 2; Pages: 193
Metastatic prostate cancer (mPCa) is one of the leading causes of cancer-related mortality in both the US and Europe. Androgen deprivation is the first-line therapy for mPCa; however, resistance to therapy inevitably occurs and the disease progresses
Autor:
Luca Pangrazzi, Sacha Genovesi, Luigi Balasco, Enrica Cerilli, Camilla Robol, Giulia Zunino, Silvano Piazza, Giovanni Provenzano, Yuri Bozzi
Publikováno v:
Journal of Neuroimmunology. 367:577870
Immune system dysfunction has been described in autism spectrum disorder. Here we tested the hypothesis that cerebellar defects are accompanied by immune dysfunction in adult mice lacking the autism-candidate gene Engrailed 2 (En2). Gene ontology ana