Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sacha A. Malin"'
Publikováno v:
Neurobiology of Disease, Vol 4, Iss 6, Pp 398-409 (1998)
Mutations in presenilin 1 (PS-1) and presenilin 2 (PS-2) have been linked to early onset, autosomal dominant Alzheimer's disease. Neither the normal function(s) of the presenilins nor their role(s) in mediating the devastating neurological and pathol
Externí odkaz:
https://doaj.org/article/57cbbe02ca08419f97cd425fd5434b1d
Autor:
Erica S. Schwartz, Derek C. Molliver, Brian M. Davis, Kathryn M. Albers, Pam Cornuet, Julie A. Christianson, Sacha A. Malin
Publikováno v:
Journal of Neuroscience. 31:10516-10528
The nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) families of growth factors regulate the sensitivity of sensory neurons. The ion channels transient receptor potential vanilloid 1 (TRPV1) and transient receptor pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb01083e040a0f424affb874ce05a00
https://doi.org/10.1523/jneurosci.2992-10.2011
https://doi.org/10.1523/jneurosci.2992-10.2011
Autor:
Cheryl L. Stucky, Nathaniel A. Jeske, Sacha A. Malin, Adrienne E. Dubin, Gina M. Story, David D. McKemy
Publikováno v:
Brain Research Reviews. 60:2-23
Pain perception begins with the activation of primary sensory nociceptors. Over the past decade, flourishing research has revealed that members of the Transient Receptor Potential (TRP) ion channel family are fundamental molecules that detect noxious
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a43bb00b7b84929d4e6a20ff9a2804
https://doi.org/10.1016/j.brainresrev.2008.12.018
https://doi.org/10.1016/j.brainresrev.2008.12.018
Publikováno v:
Brain Research. 1230:80-90
Artemin, a member of the glial cell line-derived neurotrophic factor (GDNF) family, supports a subpopulation of trigeminal sensory neurons through activation of the Ret/GFRalpha3 receptor tyrosine kinase complex. In a previous study we showed that ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b3436699a7b1fbdc985f7767257858
https://doi.org/10.1016/j.brainres.2008.06.119
https://doi.org/10.1016/j.brainres.2008.06.119
Publikováno v:
Nature Protocols. 2:152-160
Dissociated primary sensory neurons are commonly used to study growth factor-dependent cell survival, axon outgrowth, differentiation and basic mechanisms of sensory physiology and pain. Spinal or trigeminal sensory neurons can be collected from embr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d4778373d0accab11924eee30ace18
https://doi.org/10.1038/nprot.2006.461
https://doi.org/10.1038/nprot.2006.461
Autor:
Jeanne M. Nerbonne, Sacha A. Malin
Publikováno v:
The Journal of Neuroscience. 21:8004-8014
Recently, we identified four kinetically distinct voltage-gated K + currents, I Af , I As , I K , and I SS , in rat superior cervical ganglion (SCG) neurons and demonstrated that I Af and I As are differentially expressed in type I ( I Af , I K , I S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b968841191c58bc45ec2f19092d26dca
https://doi.org/10.1523/jneurosci.21-20-08004.2001
https://doi.org/10.1523/jneurosci.21-20-08004.2001
Autor:
Jeanne M. Nerbonne, Sacha A. Malin
Publikováno v:
The Journal of Neuroscience. 20:5191-5199
Electrophysiological and molecular studies have revealed considerable heterogeneity in voltage-gated K+currents and in the subunits that underlie these channels in mammalian neurons. At present, however, the relationship between native K+currents and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40b2873b54d8df24ffd40bfd5d79b87
https://doi.org/10.1523/jneurosci.20-14-05191.2000
https://doi.org/10.1523/jneurosci.20-14-05191.2000
Inflammation or pain during neonatal development can result in long-term structural and functional alterations of nociceptive pathways, ultimately altering pain perception in adulthood. We have developed a mouse model of neonatal colon irritation (NC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a12ca454fbbd8b1a7d13e10734f88a2
https://europepmc.org/articles/PMC2955795/
https://europepmc.org/articles/PMC2955795/
Autor:
Brian M. Davis, Collene E. Anderson, Sabrina L. McIlwrath, H. Richard Koerber, Sacha A. Malin, Michael P. Jankowski, Jeffrey J. Lawson
Publikováno v:
Molecular Pain
Molecular Pain, Vol 6, Iss 1, p 58 (2010)
Molecular Pain, Vol 6, Iss 1, p 58 (2010)
Background: Previous studies have shown that the TRPV1 ion channel plays a critical role in the development of heat hyperalgesia after inflammation, as inflamed TRPV1−/− mice develop mechanical allodynia but fail to develop thermal hyperalgesia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6e5dbf8c3b201cbcb449354e622c9e2
https://pubmed.ncbi.nlm.nih.gov/20858240
https://pubmed.ncbi.nlm.nih.gov/20858240
Changes in primary sensory neurons are likely to contribute to the emergence of chronic visceral pain. An important step in understanding visceral pain is the development of comprehensive phenotypes that combines functional and anatomical properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f81c9f1e2e435c19a694e8ef5da0099f
https://europepmc.org/articles/PMC2790201/
https://europepmc.org/articles/PMC2790201/