Exercise of high intensity ameliorates hepatic inflammation and the progression of NASH

Autor: Gavin Fredrickson, Fanta Barrow, Katrina Dietsche, Preethy Parthiban, Saad Khan, Sacha Robert, Maya Demirchian, Hailey Rhoades, Haiguang Wang, Oyedele Adeyi, Xavier S. Revelo

Publikováno v: Molecular Metabolism, Vol 53, Iss , Pp 101270- (2021)

Objective: Non-alcoholic fatty liver disease (NAFLD) covers a wide spectrum of liver pathology ranging from simple fatty liver to non-alcoholic steatohepatitis (NASH). Notably, immune cell-driven inflammation is a key mechanism in the transition from

Externí odkaz: https://doaj.org/article/c67bf598948b4db9ad01d40efae5b4d7

Characterization of the MMP/TIMP Imbalance and Collagen Production Induced by IL-1β or TNF-α Release from Human Hepatic Stellate Cells.

Autor: Sacha Robert, Thomas Gicquel, Aude Bodin, Vincent Lagente, Elisabeth Boichot

Publikováno v: PLoS ONE, Vol 11, Iss 4, p e0153118 (2016)

Inflammation has an important role in the development of liver fibrosis in general and the activation of hepatic stellate cells (HSCs) in particular. It is known that HSCs are themselves able to produce cytokines and chemokines, and that this product

Externí odkaz: https://doaj.org/article/8ba00ac8bb324fa9acf95b359e463272

Influence of inflammasome pathway activation in macrophages on the matrix metalloproteinase expression of human hepatic stellate cells

Autor: Emiliano Barreto, Aude Bodin, Sacha Robert, Elisabeth Boichot, Alain Fautrel, Tatiana Victoni, Thomas Gicquel, Vincent Lagente

Publikováno v: International Immunopharmacology
International Immunopharmacology, 2019, 72, pp.12-20. ⟨10.1016/j.intimp.2019.03.060⟩
International Immunopharmacology, Elsevier, 2019, 72, pp.12-20. ⟨10.1016/j.intimp.2019.03.060⟩

International audience; Inflammasomes are protein complexes that produce IL-1β in response to damage or pathogens. As such, inflammasomes are involved in several types of hepatic fibrosis. However, the mechanisms by which these complexes drive the l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5591a8ef950501fcf83b211ad4ee9f
https://doi.org/10.1016/j.intimp.2019.03.060

Obesity alters the immune landscape of the small intestine and exacerbates food allergy

Autor: Zoe C Schmiechen, Gavin Fredrickson, Sacha Robert, Fanta Barrow, Xavier Revelo

Publikováno v: The Journal of Immunology. 204:66.11-66.11

In the past few decades, higher rates of obesity have coincided with a rising number of individuals affected by allergic disease. Our study objective was to determine if obesity alters the immune cell landscape of the small intestine towards an infla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70ceebc8f098af072123351c52f609d0
https://doi.org/10.4049/jimmunol.204.supp.66.11

L’inflammasome NLRP3 : physiopathologie et application thérapeutique [The NLRP3 inflammasome: Physiopathology and therapeutic application]

Autor: Vincent Lagente, Sacha Robert, Thomas Gicquel, Tatiana Victoni

Publikováno v: La Presse Médicale
La Presse Médicale, 2016, 45 (4, part 1), pp.438-446. ⟨10.1016/j.lpm.2016.01.006⟩
La Presse Médicale, Elsevier Masson, 2016, 45 (4, part 1), pp.438-446. ⟨10.1016/j.lpm.2016.01.006⟩
La Presse Médicale, Elsevier Masson, 2016, 45 (4, part 1), pp.438-446. 〈10.1016/j.lpm.2016.01.006〉

National audience; The innate immune system constitutes the first line of host defense against pathogens. “Nonself”, such as exogenous particles or pathogens, triggers an inflammatory response. Inflammasomes are molecular platforms activated upon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52404c9a54d9ca51a502a175da915587
https://univ-rennes.hal.science/hal-01274225/file/Gicquel_NLRP3_Press_Med_2016.pdf