Effects of structurally distinct human HDAC6 and HDAC6/HDAC8 inhibitors against S. mansoni larval and adult worm stages.

Autor: Gimmelli R; Institute of Biochemistry and Cell Biology, National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo, Rome, Italy.; Dipartimento di Scienze Biochimiche 'A. Rossi Fanelli', Sapienza Università di Roma, Roma, Italy., Papoff G; Institute of Biochemistry and Cell Biology, National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo, Rome, Italy., Saccoccia F; Institute of Biochemistry and Cell Biology, National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo, Rome, Italy., Lalli C; Institute of Biochemistry and Cell Biology, National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo, Rome, Italy., Gemma S; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy., Campiani G; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy., Ruberti G; Institute of Biochemistry and Cell Biology, National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo, Rome, Italy.

Publikováno v: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2024 Feb 28; Vol. 18 (2), pp. e0011992. Date of Electronic Publication: 2024 Feb 28 (Print Publication: 2024).

Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors.

Autor: Saccoccia F; Institute of Biochemistry and Cell Biology, Italian National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo Scalo, Rome, Italy. Electronic address: fulvio.saccoccia@cnr.it., Pozzetti L; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Siena, Italy., Gimmelli R; Institute of Biochemistry and Cell Biology, Italian National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo Scalo, Rome, Italy., Butini S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Siena, Italy., Guidi A; Institute of Biochemistry and Cell Biology, Italian National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo Scalo, Rome, Italy., Papoff G; Institute of Biochemistry and Cell Biology, Italian National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo Scalo, Rome, Italy., Giannaccari M; Institute of Biochemistry and Cell Biology, Italian National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo Scalo, Rome, Italy., Brogi S; Department of Pharmacy, University of Pisa, Pisa, Italy., Scognamiglio V; Institute of Crystallography, Italian National Research Council, Department of Chemical Sciences and Materials Technologies, Monterotondo, Italy., Gemma S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Siena, Italy., Ruberti G; Institute of Biochemistry and Cell Biology, Italian National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo Scalo, Rome, Italy. Electronic address: giovina.ruberti@cnr.it., Campiani G; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Siena, Italy. Electronic address: campiani@unisi.it.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2022 Oct; Vol. 298 (10), pp. 102375. Date of Electronic Publication: 2022 Aug 13.

Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability.

Autor: Federico S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, 53100, Siena, Italy., Khan T; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, 53100, Siena, Italy., Fontana A; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, 53100, Siena, Italy., Brogi S; Department of Pharmacy, University of Pisa, 56126, Pisa, Italy., Benedetti R; Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80138, Naples, Italy., Sarno F; Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80138, Naples, Italy., Carullo G; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, 53100, Siena, Italy., Pezzotta A; Department of Medical Biotechnology and Translational Medicine, University of Milan, LITA - Via Fratelli Cervi 93, 20090, Segrate (MI), Italy., Saraswati AP; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, 53100, Siena, Italy., Passaro E; Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80138, Naples, Italy., Pozzetti L; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, 53100, Siena, Italy., Papa A; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, 53100, Siena, Italy., Relitti N; IRBM Science Park, Via Pontina Km 30,600, 00071, Pomezia, Rome, Italy., Gemma S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, 53100, Siena, Italy., Butini S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, 53100, Siena, Italy., Pistocchi A; Department of Medical Biotechnology and Translational Medicine, University of Milan, LITA - Via Fratelli Cervi 93, 20090, Segrate (MI), Italy., Ramunno A; Department of Pharmacy, University of Salerno, 84084, Fisciano (SA), Italy., Vincenzi F; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy., Varani K; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy., Tatangelo V; Department of Life Sciences, University of Siena, 53100, Siena, Italy., Patrussi L; Department of Life Sciences, University of Siena, 53100, Siena, Italy., Baldari CT; Department of Life Sciences, University of Siena, 53100, Siena, Italy., Saponara S; Department of Life Sciences, University of Siena, 53100, Siena, Italy., Gorelli B; Department of Life Sciences, University of Siena, 53100, Siena, Italy., Lamponi S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, 53100, Siena, Italy., Valoti M; Department of Life Sciences, University of Siena, 53100, Siena, Italy., Saccoccia F; Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), 00015, Monterotondo, (Rome), Italy., Giannaccari M; Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), 00015, Monterotondo, (Rome), Italy., Ruberti G; Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), 00015, Monterotondo, (Rome), Italy., Herp D; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, 79104, Freiburg, Germany., Jung M; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, 79104, Freiburg, Germany., Altucci L; Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80138, Naples, Italy; BIOGEM, Molecular Biology and Genetics Research Institute, Ariano Irpino (AV), Italy. Electronic address: lucia.altucci@unicampania.it., Campiani G; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, 53100, Siena, Italy. Electronic address: campiani@unisi.it.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2022 Aug 05; Vol. 238, pp. 114409. Date of Electronic Publication: 2022 May 01.

Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors.

Autor: Campiani G; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy., Cavella C; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy., Osko JD; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States., Brindisi M; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy., Relitti N; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy., Brogi S; Department of Pharmacy, University of Pisa, via Bonanno 6, 56126 Pisa, Italy., Saraswati AP; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy., Federico S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy., Chemi G; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy., Maramai S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy., Carullo G; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy., Jaeger B; Klinik für Pneumologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hannover 30625, Germany., Carleo A; Klinik für Pneumologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hannover 30625, Germany., Benedetti R; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Vico L. de Crecchio 7, 80138 Naples, Italy., Sarno F; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Vico L. de Crecchio 7, 80138 Naples, Italy., Lamponi S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy., Rottoli P; Specialization School of Respiratory Diseases, Department of Medical Sciences, Surgery and Neurosciences, Centro didattico Le Scotte, University of Siena, 53100 Siena, Italy., Bargagli E; Department of Medical Sciences, Surgery and Neurosciences, Respiratory Diseases Unit, AOUS, Centro didattico Le Scotte, University of Siena, 53100 Siena, Italy., Bertucci C; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro, 6, Bologna 40126, Italy., Tedesco D; Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro, 6, Bologna 40126, Italy., Herp D; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104 Freiburg, Germany., Senger J; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104 Freiburg, Germany., Ruberti G; Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), via E. Ramarini 32, 00015 Monterotondo (Rome), Italy., Saccoccia F; Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), via E. Ramarini 32, 00015 Monterotondo (Rome), Italy., Saponara S; Department of Life Sciences, University of Siena, via Aldo Moro 2, I-53100 Siena, Italy., Gorelli B; Department of Life Sciences, University of Siena, via Aldo Moro 2, I-53100 Siena, Italy., Valoti M; Department of Life Sciences, University of Siena, via Aldo Moro 2, I-53100 Siena, Italy., Kennedy B; UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, D04 V1W8 Dublin, Ireland., Sundaramurthi H; UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, D04 V1W8 Dublin, Ireland., Butini S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy., Jung M; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104 Freiburg, Germany., Roach KM; Department of Respiratory Sciences, University of Leicester, UK, Institute of Lung Health and NIHR Leicester BRC-Respiratory, LE5 4PW Leicester, U.K., Altucci L; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Vico L. de Crecchio 7, 80138 Naples, Italy., Bradding P; Department of Respiratory Sciences, University of Leicester, UK, Institute of Lung Health and NIHR Leicester BRC-Respiratory, LE5 4PW Leicester, U.K., Christianson DW; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, United States., Gemma S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100 Siena, Italy., Prasse A; Klinik für Pneumologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hannover 30625, Germany.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Jul 22; Vol. 64 (14), pp. 9960-9988. Date of Electronic Publication: 2021 Jul 12.

Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation.

Autor: Relitti N; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy., Saraswati AP; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy., Chemi G; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy., Brindisi M; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy., Brogi S; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126, Pisa, Italy., Herp D; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104, Freiburg, Germany., Schmidtkunz K; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104, Freiburg, Germany., Saccoccia F; Institute of Biochemistry and Cell Biology, CNR, Campus A. Buzzati-Traverso. Via E. Ramarini 32, 00015, Monterotondo, Rome, Italy., Ruberti G; Institute of Biochemistry and Cell Biology, CNR, Campus A. Buzzati-Traverso. Via E. Ramarini 32, 00015, Monterotondo, Rome, Italy., Ulivieri C; Department of Life Sciences, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy., Vanni F; Department of Life Sciences, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy., Sarno F; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Vico L. de Crecchio 7, 80138, Naples, Italy., Altucci L; Department of Precision Medicine, University of Campania Luigi Vanvitelli, Vico L. de Crecchio 7, 80138, Naples, Italy., Lamponi S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy., Jung M; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104, Freiburg, Germany., Gemma S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy., Butini S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy., Campiani G; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy. Electronic address: campiani@unisi.it.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2021 Feb 15; Vol. 212, pp. 112998. Date of Electronic Publication: 2020 Nov 07.