Výsledky vyhledávání - "Saccharomyces cerevisiae Proteins/genetics"

Unlocking the functional potential of polyploid yeasts

Autor: Simone Mozzachiodi, Kristoffer Krogerus, Brian Gibson, Alain Nicolas, Gianni Liti

Publikováno v: Mozzachiodi, S, Krogerus, K, Gibson, B, Nicolas, A & Liti, G 2022, ' Unlocking the functional potential of polyploid yeasts ', Nature Communications, vol. 13, no. 1, 2580 . https://doi.org/10.1038/s41467-022-30221-x

Breeding and domestication have generated widely exploited crops, animals and microbes. However, many Saccharomyces cerevisiae industrial strains have complex polyploid genomes and are sterile, preventing genetic improvement strategies based on breed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643e2d571bc13ceee50535150c51f83d
https://doi.org/10.1038/s41467-022-30221-x

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Chl1 helicase controls replication fork progression by regulating dNTP pools

Autor: Amandine Batté, Sophie C van der Horst, Mireille Tittel-Elmer, Su Ming Sun, Sushma Sharma, Jolanda van Leeuwen, Andrei Chabes, Haico van Attikum

Publikováno v: Life Science Alliance, 5(4). LIFE SCIENCE ALLIANCE LLC
Life science alliance, vol. 5, no. 4, pp. e202101153
Life Science Alliance
Life Science Alliance, 5(4)

Chl1 helicase affects RPA-dependent checkpoint activation after replication fork arrest by ensuring proper dNTP levels, thereby controlling replication fork progression under stress conditions.
Eukaryotic cells have evolved a replication stress

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d692bbaa302ffcdd800c03774c07b57
http://hdl.handle.net/1887/3564799

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Multiple nutrient transporters enable cells to mitigate a rate-affinity tradeoff

Autor: Luis Fernando Montaño-Gutierrez, Kevin Correia, Peter S. Swain

Publikováno v: Montano Gutierrez, L F, Correia, K & Swain, P S 2022, ' Multiple nutrient transporters enable cells to mitigate a rate-affinity tradeoff ', PLoS Computational Biology, vol. 18, no. 4, e1010060 . https://doi.org/10.1371/journal.pcbi.1010060

Eukaryotic genomes often encode multiple transporters for the same nutrient. For example, budding yeast has 17 hexose transporters (HXTs), all of which potentially transport glucose. Using mathematical modelling, we show that transporters that use ei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8445ea306856b384bc9726b9b031142
https://pubmed.ncbi.nlm.nih.gov/35468136

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Global mapping of protein–metabolite interactions in Saccharomyces cerevisiae reveals that Ser-Leu dipeptide regulates phosphoglycerate kinase activity

Publikováno v: Communications Biology
Communications Biology, Nature Publishing Group, 2021, 4 (1), 15 p. ⟨10.1038/s42003-021-01684-3⟩
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)

Protein–metabolite interactions are of crucial importance for all cellular processes but remain understudied. Here, we applied a biochemical approach named PROMIS, to address the complexity of the protein–small molecule interactome in the model y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d74a7a22f23f1e3250092622abb758
https://doi.org/10.1038/s42003-021-01684-3

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Functional and transcriptional profiling of non-coding RNAs in yeast reveal context-dependent phenotypes and in trans effects on the protein regulatory network

Autor: Daniela Delneri, Soukaina Timouma, Marcin G. Fraczek, Raymond T. O'Keefe, Catherine B. Millar, Steven Parker, Ping Wang, Laura Natalia Balarezo-Cisneros

Publikováno v: Balarezo-Cisneros, L N, Parker, S, Fraczek, M G, Timouma, S, Wang, P, O'Keefe, R T, Millar, C B & Delneri, D 2021, ' Functional and transcriptional profiling of non-coding RNAs in yeast reveal context-dependent phenotypes and in trans effects on the protein regulatory network ', PLoS Genetics, vol. 17, no. 1, e1008761 . https://doi.org/10.1371/journal.pgen.1008761
PLoS Genetics
PLoS Genetics, Vol 17, Iss 1, p e1008761 (2021)

Non-coding RNAs (ncRNAs), including the more recently identified Stable Unannotated Transcripts (SUTs) and Cryptic Unstable Transcripts (CUTs), are increasingly being shown to play pivotal roles in the transcriptional and post-transcriptional regulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5229b68a60ccbb802158bf2ff091d9f2
https://www.research.manchester.ac.uk/portal/en/publications/functional-and-transcriptional-profiling-of-noncoding-rnas-in-yeast-reveal-contextdependent-phenotypes-and-in-trans-effects-on-the-protein-regulatory-network(8b9cfaa5-7364-41ad-beaa-a805b5d78d30).html

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Yeast Ppz1 protein phosphatase toxicity involves the alteration of multiple cellular targets

Autor: Saint-Marc, Christelle, Ceschin, Johanna, Almyre, Claire, Pinson, Benoît, Daignan-Fornier, Bertrand, Velázquez, Diego, Albacar, Marcel, Zhang, Chunyi, Calafí, Carlos, López-Malo, María, Torres-Torronteras, Javier, Martí, Ramón, Kovalchuk, Sergey, Jensen, Ole, Casamayor, Antonio, Ariño, Joaquín

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, In press, ⟨10.1038/s41598-020-72391-y⟩
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-72391-y⟩
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.15613. ⟨10.1038/s41598-020-72391-y⟩
Velázquez, D, Albacar, M, Zhang, C, Calafí, C, López-Malo, M, Torres-Torronteras, J, Martí, R, Kovalchuk, S I, Pinson, B, Jensen, O N, Daignan-Fornier, B, Casamayor, A & Ariño, J 2020, ' Yeast Ppz1 protein phosphatase toxicity involves the alteration of multiple cellular targets ', Scientific Reports, vol. 10, 15613 . https://doi.org/10.1038/s41598-020-72391-y
Scientific Reports, Vol 10, Iss 1, Pp 1-22 (2020)

Control of the protein phosphorylation status is a major mechanism for regulation of cellular processes, and its alteration often lead to functional disorders. Ppz1, a protein phosphatase only found in fungi, is the most toxic protein when overexpres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3563f1708dad9a1b50f9560b31212b26
http://europepmc.org/articles/PMC7519054

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Phospho-regulation of the Shugoshin - Condensin interaction at the centromere in budding yeast

Autor: Jennifer Röhrl, Zuzana Storchova, Stephan Gruber, Karolina Peplowska, Young-Min Soh, Frank Bürmann, Yehui Wu, Galal Yahya Metwaly

Publikováno v: PLoS genetics, vol. 16, no. 8, pp. e1008569
PLoS Genetics
PLoS Genetics, Vol 16, Iss 8, p e1008569 (2020)

Correct bioriented attachment of sister chromatids to the mitotic spindle is essential for chromosome segregation. In budding yeast, the conserved protein shugoshin (Sgo1) contributes to biorientation by recruiting the protein phosphatase PP2A-Rts1 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5c1836a69091431c807a715b7af139
https://serval.unil.ch/resource/serval:BIB_D23C2314CE14.P001/REF.pdf

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Activation of SNF1/AMPK mediates the mitochondrial derepression, resistance to oxidative stress and increased lifespan of cells lacking the phosphatase Sit4p

Autor: Andreia T. Pereira, Clara Pereira, Vítor Costa

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

This article is a result of the project Norte-01-0145-FEDER-000008 -Porto Neurosciences and Neurologic Disease Research Initiative at I3Ssupported by Norte Portugal Regional Operational Programme (NORTE2020), under the PORTUGAL 2020 Partnership Agree

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885d225738f4eabee224c24127955846
https://hdl.handle.net/10216/130573

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tRNA 2'-O-methylation by a duo of TRM7/FTSJ1 proteins modulates small RNA silencing in Drosophila

Publikováno v: Nucleic acids research, vol. 48, no. 4, pp. 2050-2072
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2020, 48 (4), pp.2050-2072. ⟨10.1093/nar/gkaa002⟩
Nucleic Acids Research, Oxford University Press, 2020, ⟨10.1093/nar/gkaa002⟩

2′-O-Methylation (Nm) represents one of the most common RNA modifications. Nm affects RNA structure and function with crucial roles in various RNA-mediated processes ranging from RNA silencing, translation, self versus non-self recognition to viral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3016f881fc9b48b02b58bc910d26df8c
https://serval.unil.ch/resource/serval:BIB_54F1E8540412.P001/REF.pdf

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