Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sac P. Tang"'
Autor:
Els F. Halff, Sridhar Natesan, David R. Bonsall, Mattia Veronese, Anna Garcia-Hidalgo, Michelle Kokkinou, Sac-Pham Tang, Laura J. Riggall, Roger N. Gunn, Elaine E. Irvine, Dominic J. Withers, Lisa A. Wells, Oliver D. Howes
Publikováno v:
Molecular Imaging, Vol 2022 (2022)
Positron emission tomography (PET) using the radiotracer [18F]-FDOPA provides a tool for studying brain dopamine synthesis capacity in animals and humans. We have previously standardised a micro-PET methodology in mice by intravenously administering
Externí odkaz:
https://doaj.org/article/f768fa347d054483bb676f5799b52e6f
Autor:
Nicholas Maughan Clayton, Gerard Martin Paul Giblin, Mark Patrick Healy, Anton D. Michel, Riccardo Novelli, Beverley Hammond, Stephen John Atkinson, Sac P. Tang, Susan H. Brown, Matthew R. Johnson, Anita Chowdhury, Alan Naylor, David J. Spalding, Adrian Hall, Iain P. Chessell, Robert Gleave, Tanya Coleman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3657-3662
The preliminary SAR of a series of novel 1,5-biaryl pyrrole EP1 receptor antagonists derived from compound 1 is described. Replacement of the benzyl group of 1 with isosteric groups was investigated. The most effective replacement was found to be the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660d917808d82d10a3a4c9492e5fca4d
https://doi.org/10.1016/j.bmcl.2006.04.073
https://doi.org/10.1016/j.bmcl.2006.04.073
Akademický článek
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Autor:
David Spalding, Adrian Hall, Gerard Martin Paul Giblin, Nicholas Maughan Clayton, Rino A. Bit, Tiziana Scoccitti, Iain P. Chessell, Anita Chowdhury, Riccardo Novelli, David Nigel Hurst, Alan Naylor, Alex W. Wilson, Helene M. Chaignot, Sac P. Tang, Susan H. Brown, Rich Wilson, Beverley Hammond, Anton D. Michel, Tanya Coleman
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(2)
The discovery of a series of selective EP1 receptor antagonists based on a 1,2-diarylcyclopentene template is described. After defining the structural requirements for EP1 potency and selectivity, heterocyclic rings were incorporated to reduce log D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e9b9eff5bda17de702d63fb35717de
https://pubmed.ncbi.nlm.nih.gov/17084082
https://pubmed.ncbi.nlm.nih.gov/17084082
Autor:
David J. Spalding, Adrian Hall, Shiyam Mohamed, Helene M. Chaignot, Ian R. Kilford, Gerard Martin Paul Giblin, Lee Skinner, Iain P. Chessell, Tanya Coleman, Richard J. Wilson, Anton D. Michel, Rino A. Bit, Susan H. Brown, Sac P. Tang, Alan Naylor, Riccardo Novelli, Xiao Qing Lewell, David N. Hurst
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(10)
We describe the generation of novel EP 1 receptor antagonists by investigation of thiophene isosteres. In addition, we disclose preliminary in vitro and in vivo DMPK for selected compounds.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb0c808d5c3af39816177bb8bd7a9a4
https://pubmed.ncbi.nlm.nih.gov/16503138
https://pubmed.ncbi.nlm.nih.gov/16503138
Akademický článek
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