Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Saburo Otsuki"'
Autor:
Kazufumi Akiyama, Saburo Otsuki
Publikováno v:
Psychiatry and Clinical Neurosciences. 51:347-356
Neurobiological research in schizophrenia has been hampered by several confounding factors such as the heterogeneity of the illness and the paucity of biological markers. Recent progress in research methods, however, has enabled the improvement in ou
Publikováno v:
European Journal of Pharmacology. 296:123-128
The effects of putative sigma receptor antagonists, BMY-14802 (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine), rimcazole and SR-31742A (cis-3-(hexahydroazepin-1-yl)1-(3-chloro-4- cyclohexylphenyl)propene-1), on the development of beh
Autor:
Yutaka Fujiwara, Hiroaki Tomita, Kenichi Kashihara, Mitsuru Hikiji, William R. Roeske, Ichiro Sora, Saburo Otsuki, Toshikazu Oki, Yasutaro Hamagishi, Henry I. Yamamura, Tetsuo Ohnuki
Publikováno v:
Life Sciences. 52:949-958
We have previously isolated the rat serotonin (5-HT) 1A receptor gene (G21Y2) and now report the expression and characterization of this receptor. The BamHl/Xbal fragment of this gene was cloned into Rc/RSV and stably transfected into HeLa cells by t
Publikováno v:
Psychiatry and Clinical Neurosciences. 46:957-966
Synaptosomal membrane fluidity, lipid peroxide (LPO) and cytosolic superoxide dismutase (SOD) activity were examined in various brain regions (amygdala, hippocampus, striatum and frontal cortex) of amygdala-kindled rats. At 24 h after the last seizur
Autor:
Hideki Ishizu, Saburo Otsuki, Hiroaki Tomita, Ichiro Sora, Yutaka Fujiwara, Henry I. Yamamura, Kazufumi Akiyama
Publikováno v:
Psychiatry and Clinical Neurosciences. 46:967-973
In order to investigate whether changes of the two mRNAs encoding the D2 receptor isoforms were induced by chronic haloperidol or methamphetamine treatment in rats, we measured the brain mRNA levels using in situ hybridization histochemistry (ISHH).
Autor:
Keiko Sato, Saburo Otsuki, Kiyoshi Morimoto, Hideki Ishizu, Kensuke Kawai, Norihito Yamada, Koutaro Inoue
Publikováno v:
Psychiatry and Clinical Neurosciences. 46:361-367
Publikováno v:
Journal of Neural Transmission. 90:137-144
Intraperitoneal injection of (+)-3-[3-hydroxyphenyl)-N-(1-propyl)piperidine ((+)-3PPP), a sigma receptor agonist, significantly reduced the striatal levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) measured
Publikováno v:
European Journal of Pharmacology. 211:323-328
Functional changes in sigma receptors were examined after behavioral sensitization induced by repeated methamphetamine treatment. Rats received either saline or 4 mg/kg methamphetamine for 14 days. (+)3-(3-hydroxyphenyl)-N-(1-propyl)piperidine ((+)-3
Autor:
Takashi Itoh, Hiroshi Ujike, Akihiro Daigen, Saburo Otsuki, Norihito Yamada, Ichiro Kohira, Kazufumi Akiyama
Publikováno v:
Brain Research. 569:71-77
We have previously demonstrated that ibotenate (IBO)-stimulated polyphosphoinositide (PPI) hydrolysis is increased for a long period in the amygdala/pyriform cortex (AM/PC) of amygdala (AM)- and hippocampal (HIPP)-kindled rats. This finding indicates
Publikováno v:
Life Sciences. 50:1673-1681
In order to elucidate the possible roles of the glutamate system in the mechanisms underlying behavioral sensitization, which is used as an animal model for human psychosis, we investigated the effects of 3-((±)-2-carboxypiperazin-4-yl)propyl-1-phos