Výsledky vyhledávání - "Sabrina Zappitelli"

Comparison of the molecular interactions of two antagonists, MEN16132 or icatibant, at the human kinin B2 receptor

Autor: C.A. Maggi, Laura Quartara, Paola Cucchi, Luigi Rotondaro, Sandro Giuliani, Alessandro Giolitti, Francesca Bellucci, Sabrina Zappitelli, Claudio Catalani, Stefania Meini

Publikováno v: British Journal of Pharmacology. 162:1202-1212

BACKGROUND AND PURPOSE Icatibant is a well-known kinin B2 receptor antagonist currently used for angiooedema attacks. MEN16132 is a non-peptide B2 receptor antagonist, more potent and long lasting than icatibant in different models. Here we studied t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f5c166200d1c2ee03a8ade20b775f0e
https://doi.org/10.1111/j.1476-5381.2010.01133.x

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Pharmacology of an original and selective nonpeptide antagonist ligand for the human tachykinin NK2 receptor

Autor: Maria Altamura, Antonio Guidi, Paola Cucchi, Carlo Alberto Maggi, Alessandro Giolitti, Claudio Catalani, Luigi Rotondaro, Franco Pasqui, Stefania Meini, Sabrina Zappitelli, Sandro Giuliani, Francesca Bellucci

Publikováno v: European Journal of Pharmacology. 516:104-111

The pharmacological outline of a novel and original antagonist at the human tachykinin NK 2 receptor is presented, namely MEN13510 ( N - N ′-bis-[2-(1 H -indol-3-yl)-ethyl]- N , N ′-bis-(3-thiomorpholin-4-yl-propyl)-phthalamide). MEN13510 retaine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc34690a2ecc91033cda238a0c124076
https://doi.org/10.1016/j.ejphar.2005.04.033

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Bradykinin B2and GPR100 receptors: a paradigm for receptor signal transduction pharmacology

Autor: Alessandro Giolitti, Sandro Giuliani, Francesca Bellucci, Paola Cucchi, Katrin Boels, Stefania Meini, Sabrina Zappitelli, Carlo Alberto Maggi, Laura Quartara, Luigi Rotondaro

Publikováno v: British Journal of Pharmacology. 143:938-941

The aim of the present report was to investigate the ligand selectivity of the human orphan G-protein-coupled receptor GPR100 (hGPR100), recently identified as a novel bradykinin (BK) receptor, as compared with that of the human B2 receptor (hB2R) st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bcf95daa8b4d06f85d0b12a999bbb6e0
https://doi.org/10.1038/sj.bjp.0706025

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The N-terminal of Icatibant and bradykinin interact with the same Asp residues in the human B2 receptor

Autor: Laura Quartara, Stefania Meini, Carlo Alberto Maggi, Paola Cucchi, Alessandro Giolitti, Luigi Rotondaro, Sandro Giuliani, Francesca Bellucci, Sabrina Zappitelli, Claudio Catalani

Publikováno v: European Journal of Pharmacology. 491:121-125

The pharmacology of peptide and non-peptide bradykinin B2 receptor ligands was evaluated in the inositol phosphate (IP) production assay in CHO cells expressing the human bradykinin B2 receptor. The effect of single and double alanine mutation of D26

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ffc5fcaf715ad1daca3efcb0ae2a84
https://doi.org/10.1016/j.ejphar.2004.03.031

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A different molecular interaction of bradykinin and the synthetic agonist FR190997 with the human B2receptor: evidence from mutational analysis

Autor: Luigi Rotondaro, Carlo Alberto Maggi, Stefania Meini, Alessandro Giolitti, Sabrina Zappitelli, Wolfgang Reichert, Paola Cucchi, Francesca Bellucci, Laura Quartara, Claudio Catalani

Publikováno v: British Journal of Pharmacology. 140:500-506

Binding affinity at the [3H]-BK binding site and activity as inositol phosphate (IP) production by the peptide bradykinin (BK) and the nonpeptide FR190997 were studied at wild-type or point-mutated human B2 receptors (hB2R) expressed in CHO cells. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17229a2a189b1a6a1e6db6b72792f33d
https://doi.org/10.1038/sj.bjp.0705454

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Monocyclic Human Tachykinin NK-2 Receptor Antagonists as Evolution of a Potent Bicyclic Antagonist: QSAR and Site-Directed Mutagenesis Studies

Autor: Francesca Bellucci, Stefania Meini, Riccardo Patacchini, Carlo Alberto Maggi, Danilo Giannotti, Sabrina Zappitelli, Luigi Rotondaro, Maria Altamura, Alessandro Giolitti

Publikováno v: Journal of Medicinal Chemistry. 45:3418-3429

A new series of monocyclic pseudopeptidic tachykinin NK-2 receptor antagonists has been derived from nepadutant with the help of site-directed mutagenesis studies and QSAR models. MEN11558 is the lead compound which is evaluated on a series of 13 new

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af41003ac4c5f8184d78d2765fd20002
https://doi.org/10.1021/jm011127h

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Preliminary mutational analysis of the human kinin B2receptor for nonpeptide antagonist ligands recognition

Autor: Alessandro Giolitti, Laura Quartara, Stefania Meini, Carlo Alberto Maggi, Paola Cucchi, Sabrina Zappitelli, Luigi Rotondaro

Publikováno v: Canadian Journal of Physiology and Pharmacology. 80:303-309

FR173657, LF16,0335, and LF16,0687 are nonpeptide antagonists, endowed with high affinity and selectivity for the human kinin B2receptor. The kinin B2receptor belongs to the family of G-protein-coupled receptors with seven transmembrane (TM) helices.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f28de6f5ff747a23096c8eff5b4b8a
https://doi.org/10.1139/y02-027

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Molecular determinants of peptide and nonpeptide NK-2 receptor antagonists binding sites of the human tachykinin NK-2 receptor by site-directed mutagenesis

Autor: Luigi Rotondaro, Paola Cucchi, Sabrina Zappitelli, Carlo Alberto Maggi, Anna Rita Renzetti, Alessandro Giolitti

Publikováno v: Neuropharmacology. 39:1422-1429

A series of 14 mutants on nine selected residues of the human tachykinin NK 2 receptor was produced and stably transfected into CHO cells to investigate the binding of the peptide MEN 11420 and the nonpeptide SR 48968 antagonists. The main interactio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fbaea60c42dc9866ca4d019bf679ed7
https://doi.org/10.1016/s0028-3908(00)00008-3

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A different molecular interaction of bradykinin and the synthetic agonist FR190997 with the human B2 receptor: evidence from mutational analysis

Autor: Francesca, Bellucci, Stefania, Meini, Paola, Cucchi, Claudio, Catalani, Wolfgang, Reichert, Sabrina, Zappitelli, Luigi, Rotondaro, Laura, Quartara, Alessandro, Giolitti, Carlo Alberto, Maggi

Publikováno v: British journal of pharmacology. 140(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f65fbe79883389cd87954367d8747524
https://pubmed.ncbi.nlm.nih.gov/12970081

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Interaction of linear and cyclic peptide antagonists at the human B(2) kinin receptor

Autor: Carlo Alberto Maggi, Luigi Rotondaro, Paola Cucchi, Laura Quartara, Alessandro Giolitti, Stefania Meini, Sabrina Zappitelli

Publikováno v: Peptides. 23(8)

The ligand receptor interactions involving the C-terminal moiety of kinin B 2 receptor antagonists Icatibant (H-DArg-Arg-Pro-Hyp-Gly-Thi-Ser-Dtic-Oic-Arg-OH), MEN 11270 (H-DArg-Arg-Pro-Hyp-Gly-Thi-c(Dab-Dtic-Oic-Arg)c(7γ-10α)) and a series of analo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43c529ebd1817e53d0f9a2e7e113643
https://pubmed.ncbi.nlm.nih.gov/12182947

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