Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Sabrina Tran"'
1
Akademický článek
Three-dimensional tissue-engineered human skeletal muscle model of Pompe disease
Autor: Jason Wang, Chris J. Zhou, Alastair Khodabukus, Sabrina Tran, Sang-Oh Han, Aaron L. Carlson, Lauran Madden, Priya S. Kishnani, Dwight D. Koeberl, Nenad Bursac
Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Wang et al. describe the development of a 3D in vitro model of human skeletal muscle that recapitulates the pathophysiology of Pompe disease. They further define a Pompe disease-specific transcriptional signature, confirm its presence in the Pompe my
Externí odkaz: https://doaj.org/article/e7bed5b1c04b4acdbdebddf5309410f2
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3
Three-dimensional tissue-engineered human skeletal muscle model of Pompe disease
Autor: Dwight D. Koeberl, Sabrina Tran, Chris J. Zhou, Alastair Khodabukus, Lauran Madden, Aaron L. Carlson, Priya S. Kishnani, Jason Wang, Nenad Bursac, Sang-oh Han
Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology
In Pompe disease, the deficiency of the lysosomal enzyme acid alpha-glucosidase (GAA) causes skeletal and cardiac muscle weakness, respiratory failure, and premature death. While enzyme replacement therapy using recombinant human GAA (rhGAA) can sign
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88678a75aca4a7e40d5e15cc993eb9f
https://doaj.org/article/e7bed5b1c04b4acdbdebddf5309410f2
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6
Catalytic Enantioselective Birch-Heck Sequence for the Synthesis of Phenanthridinone Derivatives with an All-Carbon Quaternary Stereocenter
Autor: Mary Sexton, William P. Malachowski, Glenn P. A. Yap, Diana Rachii, Greg Feldman, Andrew T. Krasley, Zhilin Chen, My Anh Tran, Kalyn Wiley, Alexandra Matei, Samantha Petersen, Sabrina Tran Tien
Publikováno v: J Org Chem
Novel phenanthridinone analogs with an all-carbon quaternary stereocenter have been enantioselectively synthesized using the Birch-Heck sequence. Flat phenanthridinone structures have extensive bioactivity, but consequently also suffer from poor ther
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50afe350b680fdcd7e23b8b7252f967a
https://europepmc.org/articles/PMC9382569/
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7
Akademický článek
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8
Myoblast deactivation within engineered human skeletal muscle creates a transcriptionally heterogeneous population of quiescent satellite-like cells
Autor: Jason Wang, Torie Broer, Taylor Chavez, Chris J. Zhou, Sabrina Tran, Yu Xiang, Alastair Khodabukus, Yarui Diao, Nenad Bursac
Publikováno v: Biomaterials
Satellite cells (SCs), the adult Pax7-expressing stem cells of skeletal muscle, are essential for muscle repair. However, in vitro investigations of SC function are challenging due to isolation-induced SC activation, loss of native quiescent state, a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cd1445aa471729fc8834de09bbf0e90
https://pubmed.ncbi.nlm.nih.gov/35421801
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9
Genome sequence, metabolic properties and cyanobacterial attachment of Porphyrobacter sp. HT-58-2 isolated from a filamentous cyanobacterium-microbial consortium
Autor: Ran Zhang, Sabrina Tran, Rebecca-Ayme Hughes, Yunlong Zhang, Xiaohe Jin, Philip G. Williams, Eric S. Miller, Jonathan S. Lindsey
Publikováno v: Microbiology (Reading, England). 164(10)
Tolyporphins are structurally diverse tetrapyrrole macrocycles produced by the cyanobacterial culture HT-58-2. Although tolyporphins were discovered over 25 years ago, little was known about the microbiology of the culture. The studies reported herei
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27bb18aff8a1c053f80fc8bf66b5ee96
https://pubmed.ncbi.nlm.nih.gov/30117798
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10
Catalytic Enantioselective Birch-Heck Sequence for the Synthesis of Tricyclic Structures with All-Carbon Quaternary Stereocenters
Autor: Sabrina Tran Tien, Andrew T. Krasley, Hannah M. Terz, William P. Malachowski
Publikováno v: Organic letters. 20(7)
A new enantioselective desymmetrizing Mizoroki-Heck reaction is reported. The process affords high yields and enantioselectivities of tricyclic structures containing all-carbon quaternary stereocenters. The substrates for the reaction are efficiently
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489dba59557a52a9f2881f71e24cfab7
https://pubmed.ncbi.nlm.nih.gov/29561159
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