Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Sabrina Semprini"'
Autor:
Claire V Harper, Bärbel Finkenstädt, Dan J Woodcock, Sönke Friedrichsen, Sabrina Semprini, Louise Ashall, David G Spiller, John J Mullins, David A Rand, Julian R E Davis, Michael R H White
Publikováno v:
PLoS Biology, Vol 9, Iss 4, p e1000607 (2011)
In individual mammalian cells the expression of some genes such as prolactin is highly variable over time and has been suggested to occur in stochastic pulses. To investigate the origins of this behavior and to understand its functional relevance, we
Externí odkaz:
https://doaj.org/article/188cf6c3240644bba2dec08fe24b29a3
Autor:
Michael R. H. White, Sabrina Semprini, Claire V. Harper, Nicholas Jones, David G. Spiller, Karen Featherstone, Anne V McNamara, Antony A Adamson, Hiroshi Momiji, Bärbel Finkenstädt, John J. Mullins, Lee M. Dunham, David A. Rand, Raheela Awais, Julian R. E. Davis
Publikováno v:
Endocrinology
McNamara, A V, Awais, R, Momiji, H, Dunham, L, Featherstone, K, Harper, C V, Adamson, A, Semprini, S, Jones, N A, Spiller, D G, Mullins, J J, Finkenstädt, B F, Rand, D, White, M R H & Davis, J R E 2021, ' Transcription factor Pit-1 affects transcriptional timing in the dual-promoter human prolactin gene ', Endocrinology, vol. 162, no. 4, bqaa249 . https://doi.org/10.1210/endocr/bqaa249
Mcnamara, A V, Awais, R, Momiji, H, Dunham, L, Featherstone, K, Harper, C V, Adamson, A A, Semprini, S, Jones, N A, Spiller, D G, Mullins, J J, Finkenstädt, B F, Rand, D, White, M R H & Davis, J R E 2021, ' Transcription factor Pit-1 affects transcriptional timing in the dual-promoter human prolactin gene ', Endocrinology . https://doi.org/10.1210/endocr/bqaa249
McNamara, A V, Awais, R, Momiji, H, Dunham, L, Featherstone, K, Harper, C V, Adamson, A, Semprini, S, Jones, N A, Spiller, D G, Mullins, J J, Finkenstädt, B F, Rand, D, White, M R H & Davis, J R E 2021, ' Transcription factor Pit-1 affects transcriptional timing in the dual-promoter human prolactin gene ', Endocrinology, vol. 162, no. 4, bqaa249 . https://doi.org/10.1210/endocr/bqaa249
Mcnamara, A V, Awais, R, Momiji, H, Dunham, L, Featherstone, K, Harper, C V, Adamson, A A, Semprini, S, Jones, N A, Spiller, D G, Mullins, J J, Finkenstädt, B F, Rand, D, White, M R H & Davis, J R E 2021, ' Transcription factor Pit-1 affects transcriptional timing in the dual-promoter human prolactin gene ', Endocrinology . https://doi.org/10.1210/endocr/bqaa249
Gene transcription occurs in short bursts interspersed with silent periods, and these kinetics can be altered by promoter structure. The effect of alternate promoter architecture on transcription bursting is not known. We studied the human prolactin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3d33d6a6a1eeac0e7aa4fe834e169c
http://wrap.warwick.ac.uk/146862/7/WRAP-Transcription-factor-Pit-1-affects-transcriptional-timing-dual-promoter-human-prolactin-gene-Rand-2021.pdf
http://wrap.warwick.ac.uk/146862/7/WRAP-Transcription-factor-Pit-1-affects-transcriptional-timing-dual-promoter-human-prolactin-gene-Rand-2021.pdf
Autor:
Sabrina Semprini, Antony Adamson, Anne V McNamara, John J. Mullins, Michael R. H. White, Julian R. E. Davis, David G. Spiller, Lee S. S. Dunham, Alan S. McNeilly
Publikováno v:
Molecular Endocrinology
McNamara, A V, Adamson, A D, Dunham, L S S, Semprini, S, Spiller, D G, McNeilly, A S, Mullins, J J, Davis, J R E & White, M R H 2016, ' Role of Estrogen Response Element in the Human Prolactin Gene : Transcriptional Response and Timing ', Molecular Endocrinology, vol. 30, no. 2, pp. 189-200 . https://doi.org/10.1210/me.2015-1186
Mcnamara, A, Adamson, A, Dunham, L, Semprini, S, Spiller, D, McNeilly, A S, Mullins, J J, Davis, JRE & White, M 2016, ' Role of estrogen response element in the human prolactin gene: transcriptional response and timing ', Molecular Endocrinology, vol. 30, no. 2 . https://doi.org/10.1210/me.2015-1186
McNamara, A V, Adamson, A D, Dunham, L S S, Semprini, S, Spiller, D G, McNeilly, A S, Mullins, J J, Davis, J R E & White, M R H 2016, ' Role of Estrogen Response Element in the Human Prolactin Gene : Transcriptional Response and Timing ', Molecular Endocrinology, vol. 30, no. 2, pp. 189-200 . https://doi.org/10.1210/me.2015-1186
Mcnamara, A, Adamson, A, Dunham, L, Semprini, S, Spiller, D, McNeilly, A S, Mullins, J J, Davis, JRE & White, M 2016, ' Role of estrogen response element in the human prolactin gene: transcriptional response and timing ', Molecular Endocrinology, vol. 30, no. 2 . https://doi.org/10.1210/me.2015-1186
The use of bacterial artificial chromosome (BAC) reporter constructs in molecular physiology enables the inclusion of large sections of flanking DNA, likely to contain regulatory elements and enhancers regions that contribute to the transcriptional o
Autor:
Raheela Awais, Julian R. E. Davis, Alan S. McNeilly, John J. Mullins, Adriano G. Rossi, Amanda L. Patist, Karen Featherstone, Claire V. Harper, Anne V McNamara, Sabrina Semprini, Ian Dransfield, Michael R. H. White, J R McNeilly
Publikováno v:
Endocrinology. 153:2724-2734
Prolactin (PRL) is mainly expressed in the pituitary in rodents, whereas in humans, expression is observed in many extrapituitary sites, including lymphocytes. Due to the lack of adequate experimental models, the function of locally produced PRL in t
Autor:
Michael R. H. White, Julian R. E. Davis, Sönke Friedrichsen, Judith McNeilly, Alan S. McNeilly, John J. Mullins, Pawel Paszek, Sabrina Semprini, Karen Featherstone, Claire V. Harper, David G. Spiller
Publikováno v:
Harper, C V, Featherstone, K, Semprini, S, Friedrichsen, S, McNeilly, J, Paszek, P, Spiller, D G, McNeilly, A S, Mullins, J J, Davis, J R E & White, M R H 2010, ' Dynamic organisation of prolactin gene expression in living pituitary tissue ' Journal of Cell Science, vol. 123, no. 3, pp. 424-430 . https://doi.org/10.1242/jcs.060434
Harper, C V, Featherstone, K, Semprini, S, Friedrichsen, S, McNeilly, J, Paszek, P, Spiller, D G, McNeilly, A S, Mullins, J J, Davis, J R E & White, M R H 2010, ' Dynamic organisation of prolactin gene expression in living pituitary tissue ', Journal of Cell Science, vol. 123, no. 3, pp. 424-430 . https://doi.org/10.1242/jcs.060434
Harper, C V, Featherstone, K, Semprini, S, Friedrichsen, S, McNeilly, J, Paszek, P, Spiller, D G, McNeilly, A S, Mullins, J J, Davis, J R E & White, M R H 2010, ' Dynamic organisation of prolactin gene expression in living pituitary tissue ', Journal of Cell Science, vol. 123, no. 3, pp. 424-430 . https://doi.org/10.1242/jcs.060434
Gene expression in living cells is highly dynamic, but temporal patterns of gene expression in intact tissues are largely unknown. The mammalian pituitary gland comprises several intermingled cell types, organised as interdigitated networks that inte
Autor:
Sönke Friedrichsen, Michael R. H. White, Glyn Nelson, Julian R. E. Davis, Antony Adamson, Claire V. Harper, Sabrina Semprini, Michael A. Wilding, Dave Spiller, John J. Mullins
Publikováno v:
Friedrichsen, S, Harper, C V, Semprini, S, Wilding, M, Adamson, A D, Spiller, D G, Nelson, G, Mullins, J J, White, M R H & Davis, J R E 2006, ' Tumor necrosis factor-alpha activates the human prolactin gene promoter via nuclear factor-kappa B signaling ', Endocrinology, vol. 147, no. 2, pp. 773-781 . https://doi.org/10.1210/en.2005-0967
Pituitary function has been shown to be regulated by an increasing number of intrapituitary factors, including cytokines. Here we show that the important cytokine TNF-alpha activates prolactin gene transcription in pituitary GH3 cells stably expressi
Autor:
Francesca Capon, Alessandra Tacconelli, Tommaso Gobello, Giuseppe Novelli, Emiliano Giardina, Giovanna Zambruno, Giuseppe Fabrizi, Annalisa Botta, Rita Mingarelli, Angela Orecchia, Sabrina Semprini
Publikováno v:
Human Genetics. 111:310-313
Psoriasis is an inflammatory skin disorder characterised by keratinocyte hyper-proliferation and altered differentiation. To date, linkage analyses have identified at least seven distinct disease susceptibility regions (PSORS1-7). The PSORS4 locus wa
Autor:
Bruno Dallapiccola, Alessandra Tacconelli, Sabrina Semprini, Francesca Capon, Francesco Brancati, Giuseppe Novelli
Publikováno v:
Genetic Testing. 5:33-37
Spinal muscular atrophy (SMA) is an autosomal recessive disorder with a newborn prevalence of 1 in 10,000, and a carrier frequency of 1 in 40-60 individuals. The SMA locus has been mapped to chromosome 5q11.2-13. The disease is caused by a deletion o
Autor:
Sabrina Semprini, Cataldo Schietroma, Francesca Capon, Bruno Dallapiccola, Silvia Bovolenta, Antonio Pizzuti, Giuseppe Fabrizi, Giovanna Zambruno, Emanuela M. Bruscia, Giuseppe Novelli
Publikováno v:
Human Genetics. 104:130-134
We have recently assigned a locus for familial psoriasis (PS) susceptibility to the region containing the epidermal differentiation complex gene cluster on chromosome 1q21. Gene S10OA7 maps within this cluster and is reported to be markedly over-expr
Publikováno v:
Journal of the American Association for Laboratory Animal Science : JAALAS. 51(6)
In vivo bioluminescent imaging (BLI) is a sensitive and reliable technique for studying gene expression, although experiments must be controlled tightly to obtain reproducible and quantitative measurements. The luciferase reaction depends on the avai