Cancer stemness in Apc- vs. Apc/KRAS-driven intestinal tumorigenesis.

Autor: Mehrnaz Ghazvini, Petra Sonneveld, Andreas Kremer, Patrick Franken, Andrea Sacchetti, Yaser Atlasi, Sabrina Roth, Rosalie Joosten, Ron Smits, Riccardo Fodde

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e73872 (2013)

Constitutive activation of the Wnt pathway leads to adenoma formation, an obligatory step towards intestinal cancer. In view of the established role of Wnt in regulating stemness, we attempted the isolation of cancer stem cells (CSCs) from Apc- and A

Externí odkaz: https://doaj.org/article/34a08c8f80d247a9935a4d605a364338

Intestinal epithelial cell polarity defects in disease: lessons from microvillus inclusion disease

Autor: Edward E. S. Nieuwenhuis, Sabrina Roth, Kerstin Schneeberger, Sabine Middendorp

Publikováno v: Disease Models & Mechanisms
Disease Models & Mechanisms, 11(2). Company of Biologists Ltd
Disease Models & Mechanisms, Vol 11, Iss 2 (2018)

The intestinal epithelium is a highly organized tissue. The establishment of epithelial cell polarity, with distinct apical and basolateral plasma membrane domains, is pivotal for both barrier formation and for the uptake and vectorial transport of n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bebdee2f984cafe2e3b36895462d6494
https://pubmed.ncbi.nlm.nih.gov/29590640

Cancer Stemness in Apc- vs. Apc/KRAS-Driven Intestinal Tumorigenesis

Autor: Yaser Atlasi, Ron Smits, Riccardo Fodde, Andreas Kremer, Sabrina Roth, Pieter Sonneveld, Andrea Sacchetti, Mehrnaz Ghazvini, Patrick Franken, Rosalie Joosten

Publikováno v: PLoS One (print), 8(9). Public Library of Science
PLoS ONE, Vol 8, Iss 9, p e73872 (2013)
PLoS ONE

Constitutive activation of the Wnt pathway leads to adenoma formation, an obligatory step towards intestinal cancer. In view of the established role of Wnt in regulating stemness, we attempted the isolation of cancer stem cells (CSCs) from Apc- and A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10987c6e57df2b018e561710e1e2635d
https://pure.eur.nl/en/publications/ab8137e9-8a51-49f7-95c6-5d0a88e7aeb9

Paneth Cells in Intestinal Homeostasis and Tissue Injury

Autor: Owen J. Sansom, Riccardo Fodde, Sabrina Roth, Andrea Sacchetti, Andreas Kremer, Patrick Franken, Kurt I. Anderson

Publikováno v: PLoS ONE
PLoS One (print), 7(6). Public Library of Science
PLoS ONE, Vol 7, Iss 6, p e38965 (2012)

Adult stem cell niches are often co-inhabited by cycling and quiescent stem cells. In the intestine, lineage tracing has identified Lgr5(+) cells as frequently cycling stem cells, whereas Bmi1(+), mTert(+), Hopx(+) and Lrig1(+) cells appear to be mor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97522d598093a4d7ec9d95782faf5a69
https://doi.org/10.1371/journal.pone.0038965

The nature of intestinal stem cells' nurture

Autor: Riccardo Fodde, Sabrina Roth

Publikováno v: EMBO Reports, 12(6), 483-484. Wiley-Blackwell

The ‘nature versus nurture’ debate concerns the relative contributions to an individual's identity of its nature (that is, its genetic make‐up) compared with its nurture, defined as the totality of external, environmental factors. A similar typ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74da8f3402a5d6ccfd29759833f62a7b
https://pure.eur.nl/en/publications/bcb154ff-0f42-43b6-a39c-69a992467d9d