The Odad3 Gene Is Necessary for Spermatozoa Development and Male Fertility in Mice

Autor: Miriam Pasquini, Francesco Chiani, Alessia Gambadoro, Chiara Di Pietro, Renata Paoletti, Tiziana Orsini, Sabrina Putti, Ferdinando Scavizzi, Gina La Sala, Olga Ermakova

Publikováno v: Cells, Vol 13, Iss 12, p 1053 (2024)

Odad3 gene loss-of-function mutation leads to Primary Ciliary Dyskinesia (PCD), a disease caused by motile cilia dysfunction. Previously, we demonstrated that knockout of the Odad3 gene in mice replicates several features of PCD, such as hydrocephalu

Externí odkaz: https://doaj.org/article/6f1b1e21085a490eba2e1c24086819ef

Antibody gene transfer treatment drastically improves epidermal pathology in a keratitis ichthyosis deafness syndrome model using male miceResearch in context

Autor: Chiara Peres, Caterina Sellitto, Chiara Nardin, Sabrina Putti, Tiziana Orsini, Chiara Di Pietro, Daniela Marazziti, Adriana Vitiello, Arianna Calistri, Mara Rigamonti, Ferdinando Scavizzi, Marcello Raspa, Francesco Zonta, Guang Yang, Thomas W. White, Fabio Mammano

Publikováno v: EBioMedicine, Vol 89, Iss , Pp 104453- (2023)

Summary: Background: Keratitis ichthyosis deafness (KID) syndrome is a rare disorder caused by hemichannel (HC) activating gain-of-function mutations in the GJB2 gene encoding connexin (Cx) 26, for which there is no cure, or current treatments based

Externí odkaz: https://doaj.org/article/bd169d1992394aeab17af27a91b30026

Three-Dimensional X-ray Imaging of β-Galactosidase Reporter Activity by Micro-CT: Implication for Quantitative Analysis of Gene Expression

Autor: Olga Ermakova, Tiziana Orsini, Paolo Fruscoloni, Francesco Chiani, Alessia Gambadoro, Sabrina Putti, Maurizio Cirilli, Alessio Mezzi, Saulius Kaciulis, Miriam Pasquini, Marcello Raspa, Ferdinando Scavizzi, Glauco P. Tocchini-Valentini

Publikováno v: Brain Sciences, Vol 11, Iss 6, p 746 (2021)

Acquisition of detailed anatomical and molecular knowledge from intact biological samples while preserving their native three-dimensional structure is still a challenging issue for imaging studies aiming to unravel a system’s functions. Three-dimen

Externí odkaz: https://doaj.org/article/9fd906be90c645eebdf1d15854d057dc

Characterization of Glioblastoma Cells Response to Regorafenib

Autor: Maria Patrizia Mongiardi, Mariachiara Buccarelli, Alessia Formato, Elisa Orecchini, Maria Salbini, Valentina Ricci, Tiziana Orsini, Sabrina Putti, Silvia Chiesa, Lucia Ricci-Vitiani, Quintino Giorgio D’Alessandris, Roberto Pallini, Andrea Levi, Maria Laura Falchetti

Publikováno v: Cancers; Volume 14; Issue 24; Pages: 6193

Glioblastoma (GBM), the most malignant primary brain tumor in adults. Although not frequent, it has a relevant social impact because the peak incidence coincides with the age of professional maturity. A number of novel treatments have been proposed,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9182d65e69d89ab8beeaed1c3ea38993
https://doi.org/10.3390/cancers14246193

Connexin hemichannel activation by s-nitrosoglutathione synergizes strongly with photodynamic therapy potentiating anti-tumor bystander killing

Autor: Mauricio A. Retamal, Marcello Raspa, Anna Maria Salvatore, Sabrina Putti, Guang Yang, Francesco Chiani, Flavia Mazzarda, Chiara Peres, Ferdinando Scavizzi, Fabio Mammano, Tiziana Orsini, Claudia Colussi, Abraham Tettey-Matey, Yuanyuan Kuang, Chiara Nardin

Publikováno v: Cancers (Basel) 13 (2021). doi:10.3390/cancers13205062
info:cnr-pdr/source/autori:Nardin C.; Peres C.; Putti S.; Orsini T.; Colussi C.; Mazzarda F.; Raspa M.; Scavizzi F.; Salvatore A.M.; Chiani F.; Tettey-Matey A.; Kuang Y.; Yang G.; Retamal M.A.; Mammano F./titolo:Connexin hemichannel activation by s-nitrosoglutathione synergizes strongly with photodynamic therapy potentiating anti-tumor bystander killing/doi:10.3390%2Fcancers13205062/rivista:Cancers (Basel)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:13
Cancers, Vol 13, Iss 5062, p 5062 (2021)
Cancers
Volume 13
Issue 20
Cancers (Basel) (2021). doi:10.3390/ cancers13205062
info:cnr-pdr/source/autori:Chiara Nardin, Chiara Peres, Sabrina Putti, Tiziana Orsini, Claudia Colussi, Flavia Mazzarda, Marcello Raspa, Ferdinando Scavizzi, Anna Maria Salvatore, Francesco Chiani, Abraham Tettey-Matey, Yuanyuan Kuang, Guang Yang, Mauricio A. Retamal and Fabio Mammano/titolo:Connexin Hemichannel Activation by S-Nitrosoglutathione Synergizes Strongly with Photodynamic Therapy Potentiating Anti-Tumor Bystander Killing/doi:10.3390%2F cancers13205062/rivista:Cancers (Basel)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume

Simple Summary Bystander effects depend on direct cell-cell communication and/or paracrine signaling mediated by the release of soluble factors into the extracellular environment and may greatly influence therapy outcome. Although the limited data av

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02232ba0b29c91c70e346376250a77e8
https://publications.cnr.it/doc/458277