Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sabrina Nickel"'
Autor:
Mohammed Ali Selo, Anne-Sophie Delmas, Lisa Springer, Viktoria Zoufal, Johannes A. Sake, Caoimhe G. Clerkin, Hanno Huwer, Nicole Schneider-Daum, Claus-Michael Lehr, Sabrina Nickel, Oliver Langer, Carsten Ehrhardt
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Multidrug resistance-associated protein-1 (MRP1/ABCC1) is highly expressed in human lung tissues. Recent studies suggest that it significantly affects the pulmonary disposition of its substrates, both after pulmonary and systemic administration. To b
Externí odkaz:
https://doaj.org/article/dda9e160b03342e883773c34d2c21a53
Autor:
Susanne Zweerink, Verena Kallnik, Sabrina Ninck, Sabrina Nickel, Julia Verheyen, Marcel Blum, Alexander Wagner, Ingo Feldmann, Albert Sickmann, Sonja-Verena Albers, Christopher Bräsen, Farnusch Kaschani, Bettina Siebers, Markus Kaiser
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Activity-based protein profiling (ABPP) is a chemical proteomics method to profile activity states of enzymes under physiological conditions. Here the authors show that ABPP can be applied to archaeal serine hydrolases in the model organismSulfolobus
Externí odkaz:
https://doaj.org/article/d528a9e441ee4ec1bd18d1a9ea08e735
Autor:
Elisa de Ansorena, Ondřej Plíhal, George Coupland, Amaury de Montaigu, Barbara Kracher, Vivek Halder, Karolina Kubiasová, Sabrina Nickel, Markus Kaiser, Jan H. Krahn, Lenka Radová, Julian Oeljeklaus, Réka Tóth, Erich Kombrink, Markus Schlicht, Farnusch Kaschani, Mohamed Suliman
Publikováno v:
ACS Chemical Biology
Plant growth regulating properties of brevicompanines (Brvs), natural products of the fungus Penicillium brevicompactum, have been known for several years, but further investigations into the molecular mechanism of their bioactivity have not been per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f134e5d6bbdb6c18282d69a90a802b
https://doi.org/10.1021/acschembio.6b00978
https://doi.org/10.1021/acschembio.6b00978
Publikováno v:
Expert Opinion on Drug Delivery. 13:667-690
Over the past years, a significant number of papers have substantiated earlier findings proposing a role for drug transporter proteins in pulmonary drug disposition. Whilst the majority of reports present data from in vitro models, a growing number o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f51871103451e358a77e2ba0912c5f0a
https://doi.org/10.1517/17425247.2016.1140144
https://doi.org/10.1517/17425247.2016.1140144
Autor:
Mohammed Ali Selo, Nicole Schneider-Daum, Hanno Huwer, Carsten Ehrhardt, Sabrina Nickel, Caoimhe G Clerkin, Juliane Fallack, Claus-Michael Lehr
Breast cancer resistance protein (BCRP/ABCG2) has previously been identified with high expression levels in human lung. The subcellular localisation and functional activity of the transporter in lung epithelia, however, remains poorly investigated. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a4e7a2f534569b6f9ec5f584321219
https://hdl.handle.net/10033/620926
https://hdl.handle.net/10033/620926
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:601-606
Activity-based protein profiling represents a powerful methodology to probe the activity state of enzymes under various physiological conditions. Here we present the development of a para-nitrophenol phosphonate activity-based probe with structural s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0474c4c0f0e9193799077cfd731472b1
https://doi.org/10.1016/j.bmc.2011.06.041
https://doi.org/10.1016/j.bmc.2011.06.041
Autor:
Farnusch Kaschani, Sabrina Ninck, Edward W. Tate, Susanne Zweerink, Sabrina Nickel, Remigiusz A. Serwa, Markus Kaiser
Polyacetylenes are a class of alkyne-containing natural products. Although potent bioactivities and thus possible applications as chemical probes have already been reported for some polyacetylenes, insights into the biological activities or molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c7b3efba15b4f666daa17f7c7ec467
http://hdl.handle.net/10044/1/26918
http://hdl.handle.net/10044/1/26918
OCTN1‐Mediated Ergothioneine Uptake Protects Lung Epithelial Cells From Tobacco Smoke‐Induced Damage
Autor:
Sabrina Nickel, Caoimhe G Clerkin, Carsten Ehrhardt, Johanna J. Salomon, Mohammed Ali Selo, Brian Talbot, John J. Walsh
Publikováno v:
The FASEB Journal. 29
Smoking is a major contributing factor for chronic obstructive pulmonary disease (COPD). Tobacco smoke exposure causes oxidative stress which results in alveolar wall destruction, mucus hyper secre...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1354cd2633a22a08496f2917ac1eb045
https://doi.org/10.1096/fasebj.29.1_supplement.970.7
https://doi.org/10.1096/fasebj.29.1_supplement.970.7
Autor:
Marco Hellmert, Daniel Hamza, Robert Jewell, Markus Kaiser, Geraint Jones, Sabrina Nickel, Christopher A. Pearce, Silvia Ernst, Philipp Nickel
Scaffolds of natural products represent promising starting points for the development of focused compound libraries. Here, we describe the development of a synthetic route to a compound library based on the hexahydropyrrolo indole (HPI) scaffold, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156e6a12a8364c9833c6279d01f1ef55
https://www.ncbi.nlm.nih.gov/pubmed/25907365
https://www.ncbi.nlm.nih.gov/pubmed/25907365
Autor:
Sabrina Nickel, Anne Mahringer
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 44(11)
1. Breast cancer resistance protein (BCRP) is an ABC-transporter at the blood-brain barrier (BBB) facilitating efflux of xenobiotics into blood. Expression and function are regulated via estrogen-receptors (ERs). 2. 17α-Ethinylestradiol (EE2) and bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b915f467e86a902f11dafb52dd1ccb9
https://pubmed.ncbi.nlm.nih.gov/24945792
https://pubmed.ncbi.nlm.nih.gov/24945792