Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sabrina M. Lehmann"'
Autor:
Douglas T. Golenbock, Seija Lehnardt, Michael Hinz, F. Gregory Wulczyn, Oliver Peters, David Kaul, Boyoun Park, Jan Baumgart, Agnieszka Rybak, Eleonora Franzoni, Eckart Schott, Thorsten Trimbuch, Katja Derkow, Duong T. T. Nguyen, Frank L. Heppner, Christina Krüger, Hidde L. Ploegh, Robert Nitsch, Gina D. Eom, Rüdiger W. Veh, Roland E. Kälin, Olaf Ninnemann, Piet Habbel, Sabrina M. Lehmann, Karen Rosenberger
Publikováno v:
Nature Neuroscience. 15:827-835
Activation of innate immune receptors by host-derived factors exacerbates CNS damage, but the identity of these factors remains elusive. We uncovered an unconventional role for the microRNA let-7, a highly abundant regulator of gene expression in the
Autor:
David Kaul, Olaf Hoffmann, Andreas Meisel, Joerg R. Weber, Robert Nitsch, Katharina Tschimmel, Seija Lehnardt, Sabrina M. Lehmann, Christina Krueger, Sabine Cho
Publikováno v:
Journal of Neuroimmunology. 190:28-33
Toll-like receptors (TLR) recognize molecular structures associated with pathogens as well as host-derived components and initiate an inflammatory innate immune response. Microglia represent the resident immune host defense and are the major inflamma
Autor:
Karen Rosenberger, Seija Lehnardt, F. Gregory Wulczyn, Piet Habbel, David Kaul, Christina Krüger, Katja Derkow, Agnieszka Rybak, Eckart Schott, Christine Brandt, Sabrina M. Lehmann
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 189(3)
Innate immune receptors represent an evolutionarily ancient system that allows organisms to detect and rapidly respond to pathogen- and host-derived factors. TLRs are predominantly expressed in immune cells and mediate such a response. Although this
Autor:
Katharina Stohlmann, Matthias Endres, Mustafa Balkaya, Ulrich Dirnagl, Seija Lehnardt, Ute Lindauer, Georg Royl, Sabrina M. Lehmann, Andreas Meisel
Publikováno v:
Brain research. 1265
Recent experimental studies in rodents suggest that treatment with inhibitors of phosphodiesterase type 5 (PDE5) (tadalafil, sildenafil, zaprinast) not only increases cerebral blood flow but also improves functional recovery after stroke. Here, we in