Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sabrina L. Zeller"'
Autor:
Meena Jhanwar-Uniyal, Sabrina L. Zeller, Eris Spirollari, Mohan Das, Simon J. Hanft, Chirag D. Gandhi
Publikováno v:
Cells, Vol 13, Iss 5, p 409 (2024)
The mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that functions via its discrete binding partners to form two multiprotein complexes, mTOR complex 1 and 2 (mTORC1 and mTORC2). Rapamycin-sensitive mTORC1, which regulates protein
Externí odkaz:
https://doaj.org/article/07462b5f042c406781170e1feda5e21f
Autor:
Chenglong Li, Bumki Kim, Hendrik Luesch, Sabrina L. Zeller, Hyunji Lee, Jiyong Hong, Ranjala Ratnayake, Guqin Shi
Histone acetylation is an extensively investigated post-translational modification that plays an important role as an epigenetic regulator. It is controlled by histone acetyl transferases (HATs) and histone deacetylases (HDACs). The overexpression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91fbb5470770378147debed3f516e5e8
https://europepmc.org/articles/PMC5494147/
https://europepmc.org/articles/PMC5494147/
Autor:
Bumki Kim, Seongrim Byeon, Hendrik Luesch, Heekwang Park, Patrick E. Serrano, Soyoung Ryu, Qi-Yin Chen, Yanxia Liu, Jason C. Kwan, Sabrina L. Zeller, Lilibeth A. Salvador, Jiyong Hong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:3728-3731
Largazole is a potent class I selective histone deacetylase (HDAC) inhibitor. The majority of largazole analogues to date have modified the thiazole-thiazoline and the warhead moiety. In order to elucidate class I-specific structure-activity relation
Autor:
Bumki Kim, Jiyong Hong, Lilibeth A. Salvador, Yanxia Liu, Sabrina L. Zeller, Fatma H. Al-Awadhi, Qi-Yin Chen, Hendrik Luesch, Heekwang Park
Publikováno v:
ACS Medicinal Chemistry Letters. 5:905-910
Largazole is a potent and class I-selective histone deacetylase (HDAC) inhibitor purified from marine cyanobacteria and was demonstrated to possess antitumor activity. Largazole employs a unique prodrug strategy, via a thioester moiety, to liberate t