Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Sabrina L Spencer"'
Autor:
Rebecca C Adikes, Abraham Q Kohrman, Michael A Q Martinez, Nicholas J Palmisano, Jayson J Smith, Taylor N Medwig-Kinney, Mingwei Min, Maria D Sallee, Ononnah B Ahmed, Nuri Kim, Simeiyun Liu, Robert D Morabito, Nicholas Weeks, Qinyun Zhao, Wan Zhang, Jessica L Feldman, Michalis Barkoulas, Ariel M Pani, Sabrina L Spencer, Benjamin L Martin, David Q Matus
Publikováno v:
eLife, Vol 9 (2020)
Cell proliferation and quiescence are intimately coordinated during metazoan development. Here, we adapt a cyclin-dependent kinase (CDK) sensor to uncouple these key events of the cell cycle in Caenorhabditis elegans and zebrafish through live-cell i
Externí odkaz:
https://doaj.org/article/ef13a2875ea8461db4c27f46e2101a88
Autor:
Mingwei Min, Sabrina L Spencer
Publikováno v:
PLoS Biology, Vol 17, Iss 3, p e3000178 (2019)
Slow-cycling subpopulations exist in bacteria, yeast, and mammalian systems. In the case of cancer, slow-cycling subpopulations have been proposed to give rise to drug resistance. However, the origin of slow-cycling human cells is poorly studied, in
Externí odkaz:
https://doaj.org/article/880dae6d694a493c880cdc395f779085
Autor:
Sara Gookin, Mingwei Min, Harsha Phadke, Mingyu Chung, Justin Moser, Iain Miller, Dylan Carter, Sabrina L Spencer
Publikováno v:
PLoS Biology, Vol 15, Iss 9, p e2003268 (2017)
The cell-cycle field has identified the core regulators that drive the cell cycle, but we do not have a clear map of the dynamics of these regulators during cell-cycle progression versus cell-cycle exit. Here we use single-cell time-lapse microscopy
Externí odkaz:
https://doaj.org/article/2dd7841c8d704303af2b8059aa29fc1c
Publikováno v:
PLoS Biology, Vol 6, Iss 12, Pp 2831-2852 (2008)
When exposed to tumor necrosis factor (TNF) or TNF-related apoptosis-inducing ligand (TRAIL), a closely related death ligand and investigational therapeutic, cells enter a protracted period of variable duration in which only upstream initiator caspas
Externí odkaz:
https://doaj.org/article/6e4579b8ba134ad98185b2240d2465fa
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 4, p e1002482 (2012)
Stochastic fluctuations in gene expression give rise to cell-to-cell variability in protein levels which can potentially cause variability in cellular phenotype. For TRAIL (TNF-related apoptosis-inducing ligand) variability manifests itself as dramat
Externí odkaz:
https://doaj.org/article/1a70568a02dd49bdba33d80b7ca035f9
Autor:
Kathryn R. Jacobson, Aya M. Saleh, Sarah N. Lipp, Chengzhe Tian, Audrey R. Watson, Callan M. Luetkemeyer, Alexander R. Ocken, Sabrina L. Spencer, Tamara L. Kinzer-Ursem, Sarah Calve
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108838- (2024)
Summary: The extracellular matrix (ECM) is an integral part of multicellular organisms, connecting different cell layers and tissue types. During morphogenesis and growth, tissues undergo substantial reorganization. While it is intuitive that the ECM
Externí odkaz:
https://doaj.org/article/6e642685f7e54261a6510f758ebac7cd
Publikováno v:
PLoS Computational Biology, Vol 2, Iss 8, p e108 (2006)
Tumorigenesis in humans is thought to be a multistep process where certain mutations confer a selective advantage, allowing lineages derived from the mutated cell to outcompete other cells. Although molecular cell biology has substantially advanced c
Externí odkaz:
https://doaj.org/article/ec22c544863445df826428bb1b6b8db7
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113539- (2023)
Summary: Amino acids are required for cell growth and proliferation, but it remains unclear when and how amino acid availability impinges on the proliferation-quiescence decision. Here, we used time-lapse microscopy and single-cell tracking of cyclin
Externí odkaz:
https://doaj.org/article/deeb890350914ea4867c7f7a7bf40353
Publikováno v:
bioRxiv
Many cancers harbor pro-proliferative mutations of the mitogen-activated protein kinase (MAPK) pathway and many targeted inhibitors now exist for clinical use, but drug resistance remains a major issue. We recently showed that BRAF-driven melanoma ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab42bc85da173967f1f2fb71a4ff2c6
https://doi.org/10.1101/2023.03.17.533211
https://doi.org/10.1101/2023.03.17.533211
Publikováno v:
bioRxiv
Senescence, a state of permanent cell-cycle withdrawal, is difficult to distinguish from quiescence, a transient state of cell-cycle withdrawal. This difficulty arises because quiescent and senescent cells are defined by overlapping biomarkers, raisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fdc54da33d6dbe88ec20f948b9e167
https://doi.org/10.1101/2023.03.18.533242
https://doi.org/10.1101/2023.03.18.533242