Výsledky vyhledávání - "Sabrina Kuespert"

Akademický článek

CCN2/CTGF tip the balance of growth factors towards TGF-β2 in primary open-angle glaucoma

Autor: Andrea E. Dillinger, Sabrina Kuespert, Amin A. Seleem, Jakob Neuendorf, Magdalena Schneider, Rudolf Fuchshofer

Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)

TGF-β2 is the predominant TGF-β isoform within the eye. One function of TGF-β2 is to provide the eye with immune protection against intraocular inflammation. The beneficial function of TGF-β2 within the eye must be under tight control of a networ

Externí odkaz: https://doaj.org/article/0194ad2ada9643be9734e61da67451ca

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Akademický článek

Targeting TGF-ß in the Central Nervous System: Assessment of Cynomolgus Monkey—Toxicity and Pharmacokinetics for an LNA-Antisense Oligonucleotide

Autor: Sebastian Peters, Eva Wirkert, Sabrina Kuespert, Rosmarie Heydn, Sven Korte, Lars Mecklenburg, Ludwig Aigner, Siw Johannesen, Tim-Henrik Bruun, Ulrich Bogdahn

Publikováno v: Applied Sciences, Vol 12, Iss 3, p 973 (2022)

Increasingly antisense oligonucleotides (ASOs) are developed for potential treatment of CNS disorders, and due to the inability to cross the blood brain barrier, they require direct administration into the cerebrospinal fluid (CSF). In this regard, i

Externí odkaz: https://doaj.org/article/4027f861493a47a29d8001e8f86f1eb9

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Akademický článek

Safe and Effective Cynomolgus Monkey GLP—Tox Study with Repetitive Intrathecal Application of a TGFBR2 Targeting LNA-Gapmer Antisense Oligonucleotide as Treatment Candidate for Neurodegenerative Disorders

Autor: Sebastian Peters, Eva Wirkert, Sabrina Kuespert, Rosmarie Heydn, Siw Johannesen, Anita Friedrich, Susanne Mailänder, Sven Korte, Lars Mecklenburg, Ludwig Aigner, Tim-Henrik Bruun, Ulrich Bogdahn

Publikováno v: Pharmaceutics, Vol 14, Iss 1, p 200 (2022)

The capability of the adult central nervous system to self-repair/regenerate was demonstrated repeatedly throughout the last decades but remains in debate. Reduced neurogenic niche activity paralleled by a profound neuronal loss represents fundamenta

Externí odkaz: https://doaj.org/article/2be091cb44884b99a0ace5ee62d10f3a

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Akademický článek

Antisense Oligonucleotide in LNA-Gapmer Design Targeting TGFBR2—A Key Single Gene Target for Safe and Effective Inhibition of TGFβ Signaling

Autor: Sabrina Kuespert, Rosmarie Heydn, Sebastian Peters, Eva Wirkert, Anne-Louise Meyer, Mareile Siebörger, Siw Johannesen, Ludwig Aigner, Ulrich Bogdahn, Tim-Henrik Bruun

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 6, p 1952 (2020)

Antisense Oligonucleotides (ASOs) are an emerging drug class in gene modification. In our study we developed a safe, stable, and effective ASO drug candidate in locked nucleic acid (LNA)-gapmer design, targeting TGFβ receptor II (TGFBR2) mRNA. Disco

Externí odkaz: https://doaj.org/article/7b458612d8254c0e8aebceb9b9f7159e

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Akademický článek

The TGF-β System As a Potential Pathogenic Player in Disease Modulation of Amyotrophic Lateral Sclerosis

Autor: Sebastian Peters, Eva Zitzelsperger, Sabrina Kuespert, Sabine Iberl, Rosmarie Heydn, Siw Johannesen, Susanne Petri, Ludwig Aigner, Dietmar R. Thal, Andreas Hermann, Jochen H. Weishaupt, Tim-Henrik Bruun, Ulrich Bogdahn

Publikováno v: Frontiers in Neurology, Vol 8 (2017)

Amyotrophic lateral sclerosis (ALS) represents a fatal orphan disease with high unmet medical need, and a life time risk of approx. 1/400 persons per population. Based on increasing knowledge on pathophysiology including genetic and molecular changes

Externí odkaz: https://doaj.org/article/d058721d2002498e98efced3074ddb08

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Reconditioning the Neurogenic Niche of Adult Non-human Primates by Antisense Oligonucleotide-Mediated Attenuation of TGFβ Signaling

Publikováno v: Neurotherapeutics 18(3), 1963-1979 (2021). doi:10.1007/s13311-021-01045-2
Neurotherapeutics
Neurotherapeutics : official journal of the American Society for Experimental NeuroTherapeutics (ASENT) 18(3), 1963-1979 (2021). doi:10.1007/s13311-021-01045-2

Neurotherapeutics : official journal of the American Society for Experimental NeuroTherapeutics (ASENT) 18(3), 1963-1979 (2021). doi:10.1007/s13311-021-01045-2
Published by Springer, New York, NY

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a720507a761d33ae4f93f9fa50bdf546

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CCN2/CTGF promotor activity in the developing and adult mouse eye

Autor: Andrea E. Dillinger, Franziska Froemel, Rudolf Fuchshofer, Sabrina Kuespert, Ernst R. Tamm

Publikováno v: Cell and Tissue Research

CCN2/CTGF is a matricellular protein that is known to enhance transforming growth factor-β signaling and to induce a myofibroblast-like phenotype in a variety of cell types. Here, we investigated Ccn2/Ctgf promotor activity during development and in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132915c2840e8c8aab5bd2f6c0aefda4

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A novel ocular function for decorin in the aqueous humor outflow

Autor: Andrea E. Dillinger, Renato V. Iozzo, Magdalena Schneider, Rudolf Fuchshofer, Gregor R Weber, Andreas Ohlmann, Ernst R. Tamm, Harry A. Quigley, Ramona Pawlak, Sabrina Kuespert

Publikováno v: Matrix biology : journal of the International Society for Matrix Biology. 97

Primary open-angle glaucoma a neurodegenerative disorder characterized by degeneration of optic nerve axons, is a frequent cause of vision loss and blindness worldwide. Several randomized multicenter studies have identified intraocular pressure as th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28de6c029e99e8ae0b8186f4138a2941
https://pubmed.ncbi.nlm.nih.gov/33582236

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