Výsledky vyhledávání - "Sabrina K, Spicer"

Akademický článek

The impact of persistent organic pollutants on fertility: exposure to the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin alters reproductive tract immune responses

Autor: Victoria R. Stephens, Kensley B. Horner, Walter M. Avila, Sabrina K. Spicer, Riya Chinni, Emily B. Bernabe, Antentor O. Hinton, Steven M. Damo, Alison J. Eastman, Monique M. McCallister, Kevin G. Osteen, Jennifer A. Gaddy

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Exposure to environmental contaminants can result in profound effects on the host immune system. One class of environmental toxicants, known as dioxins, are persistent environmental contaminants termed “forever chemicals”. The archetype toxicant

Externí odkaz: https://doaj.org/article/bc54c466f4ce4cff912cacd846508bf6

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Akademický článek

Streptococcus agalactiae cadD alleviates metal stress and promotes intracellular survival in macrophages and ascending infection during pregnancy

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Perinatal infection with Group B Streptococcus (GBS) is associated with preterm birth, neonatal sepsis, and stillbirth. Here, Korir et al. show that gene cadD, encoding a putative metal efflux transporter, is important for metal detoxification, immun

Externí odkaz: https://doaj.org/article/597dc8cb42f34cfcbcc7b2c564bd3327

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Akademický článek

Streptococcus agalactiae npx Is Required for Survival in Human Placental Macrophages and Full Virulence in a Model of Ascending Vaginal Infection during Pregnancy

Autor: Jacky Lu, Rebecca E. Moore, Sabrina K. Spicer, Ryan S. Doster, Miriam A. Guevara, Jamisha D. Francis, Kristen N. Noble, Lisa M. Rogers, Julie A. Talbert, Michelle L. Korir, Steven D. Townsend, David M. Aronoff, Shannon D. Manning, Jennifer A. Gaddy

Publikováno v: mBio, Vol 13, Iss 6 (2022)

ABSTRACT Streptococcus agalactiae, also known as group B Streptococcus (GBS), is a Gram-positive encapsulated bacterium that colonizes the gastrointestinal tract of 30 to 50% of humans. GBS causes invasive infection during pregnancy that can lead to

Externí odkaz: https://doaj.org/article/a4dcbca43151424ab3662c888ebec53d

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Akademický článek

Analysis of Susceptibility to the Antimicrobial and Anti-Biofilm Activity of Human Milk Lactoferrin in Clinical Strains of Streptococcus agalactiae With Diverse Capsular and Sequence Types

Autor: Jacky Lu, Miriam A. Guevara, Jamisha D. Francis, Sabrina K. Spicer, Rebecca E. Moore, Schuyler A. Chambers, Kelly M. Craft, Shannon D. Manning, Steven D. Townsend, Jennifer A. Gaddy

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)

Group B Streptococcus (GBS) is one of the leading infection-related causes of adverse maternal and neonatal outcomes. This includes chorioamnionitis, which leads to preterm ruptures of membranes and can ultimately result in preterm or stillbirth. Inf

Externí odkaz: https://doaj.org/article/c791face373346cc8666685cc5e27ab7

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Anti-Biofilm Activity of Human Milk Oligosaccharides in Clinical Strains of Streptococcus agalactiae with Diverse Capsular and Sequence Types

Autor: Rebecca E. Moore, Sabrina K. Spicer, Julie A. Talbert, Shannon D. Manning, Steven D. Townsend, Jennifer A. Gaddy

Publikováno v: Chembiochem

Group B Streptococcus (GBS) is an encapsulated gram-positive bacterial pathogen which causes severe perinatal infections. Human milk oligosaccharides (HMOs) are short-chain sugars that have recently been shown to possess antimicrobial and anti-biofil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4280601a7241bc48d83594d8ae5227c
https://europepmc.org/articles/PMC10262446/

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Streptococcus agalactiae

Autor: Jacky, Lu, Rebecca E, Moore, Sabrina K, Spicer, Ryan S, Doster, Miriam A, Guevara, Jamisha D, Francis, Kristen N, Noble, Lisa M, Rogers, Julie A, Talbert, Michelle L, Korir, Steven D, Townsend, David M, Aronoff, Shannon D, Manning, Jennifer A, Gaddy

Publikováno v: mBio.

Streptococcus agalactiae, also known as group B Streptococcus (GBS), is a Gram-positive encapsulated bacterium that colonizes the gastrointestinal tract of 30 to 50% of humans. GBS causes invasive infection during pregnancy that can lead to chorioamn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::68172c3d63cf43da144e42afd50679f7
https://pubmed.ncbi.nlm.nih.gov/36409087

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Ameliorating Adverse Perinatal Outcomes with Lactoferrin: An Intriguing Chemotherapeutic Intervention

Autor: Julie A. Talbert, Jacky Lu, Sabrina K. Spicer, Rebecca E. Moore, Steven D. Townsend, Jennifer A. Gaddy

Publikováno v: Bioorg Med Chem

Adverse pregnancy outcomes affect 54 million people globally per year, with at least 50% of these attributed to infection during gestation. These include inflammation of the membranes surrounding the growing fetus (chorioamnionitis), preterm prelabor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ab3ca55e32c2d76a2204f35e189d4c
https://europepmc.org/articles/PMC10262450/

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Recent Advances on Human Milk Oligosaccharide Antimicrobial Activity

Autor: Sabrina K. Spicer, Jennifer A. Gaddy, Steven D. Townsend

Publikováno v: Curr Opin Chem Biol

Over the past century, human health has been enhanced by antimicrobial development. Following the deployment of the first antibiotics in the 1940s, bacterial resistance evolved and has increasingly outmaneuvered even the most promising antimicrobial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6b2080906e031aaf4a9145aecf210c7
https://europepmc.org/articles/PMC10262419/

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