Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sabrina J Kugler"'
Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks
Autor:
Jan‐Philipp Mallm, Murat Iskar, Naveed Ishaque, Lara C Klett, Sabrina J Kugler, Jose M Muino, Vladimir B Teif, Alexandra M Poos, Sebastian Großmann, Fabian Erdel, Daniele Tavernari, Sandra D Koser, Sabrina Schumacher, Benedikt Brors, Rainer König, Daniel Remondini, Martin Vingron, Stephan Stilgenbauer, Peter Lichter, Marc Zapatka, Daniel Mertens, Karsten Rippe
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 5, Pp 1-20 (2019)
Abstract In chronic lymphocytic leukemia (CLL), a diverse set of genetic mutations is embedded in a deregulated epigenetic landscape that drives cancerogenesis. To elucidate the role of aberrant chromatin features, we mapped DNA methylation, seven hi
Externí odkaz:
https://doaj.org/article/d531e1d3965044bc9b7dc0b0a7049c9a
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124652 (2015)
The Drosophila gene putzig (pzg) encodes a nuclear protein that is an integral component of the Trf2/Dref complex involved in the transcription of proliferation-related genes. Moreover, Pzg is found in a complex together with the nucleosome remodelin
Externí odkaz:
https://doaj.org/article/a8489cce8d594118830795f296792d53
Publikováno v:
Genetics. 188:127-139
Putzig (Pzg) was originally identified as being an integral component of the TRF2/DREF complex in Drosophila melanogaster, thereby regulating the transcriptional activation of replication-related genes. In a DREF-independent manner, Pzg was shown to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08fd1d5f1af0983c470e7788db95b632
https://doi.org/10.1534/genetics.111.127795
https://doi.org/10.1534/genetics.111.127795
Autor:
Sabrina J. Kugler, Anja C. Nagel
Publikováno v:
Molecular Biology of the Cell
The Putzig (Pzg) protein is associated with the NURF nucleosome remodeling complex, thereby promoting Notch target gene expression. Our findings suggest a novel Pzg-NURF complex that is responsible for the epigenetic regulation of Notch target genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c8da7f9ef0e23f38fe22d7f85de2e5
https://doi.org/10.1091/mbc.e10-03-0212
https://doi.org/10.1091/mbc.e10-03-0212
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124652 (2015)
PLoS ONE
PLoS ONE
The Drosophila gene putzig (pzg) encodes a nuclear protein that is an integral component of the Trf2/Dref complex involved in the transcription of proliferation-related genes. Moreover, Pzg is found in a complex together with the nucleosome remodelin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25adfd92bbd9b17a6faffcc66ce4252d
http://europepmc.org/articles/PMC4403878?pdf=render
http://europepmc.org/articles/PMC4403878?pdf=render
Overexpression of Hairless (H) causes a remarkable degree of tissue loss and apoptosis during imaginal development. H functions as antagonist in the Notch-signaling pathway in Drosophila, and the link to growth and apoptosis is poorly understood. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::934c606d66d41accedf9a6c93d99ff79
https://europepmc.org/articles/PMC1456817/
https://europepmc.org/articles/PMC1456817/
Autor:
Sabrina J. Kugler, Klaus Pfizenmaier, Irmgard Wech, Anette Preiss, Dieter Maier, Anja C. Nagel, Angelika Hausser, Gisela Link
Publikováno v:
Gene expression patterns : GEP. 6(8)
Protein kinase D belongs to the subfamily of CaMK. In mammals, three isoforms are known. They have been linked to diverse cellular functions including regulation of cell proliferation, differentiation, apoptosis and motility as well as secretory tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7e7b9e3c512ef2da3b8b0a1fbda233
https://pubmed.ncbi.nlm.nih.gov/16750940
https://pubmed.ncbi.nlm.nih.gov/16750940
Autor:
Angelika Hausser, Dieter Maier, Sabrina J. Kugler, Anja C. Nagel, Helena Gloc, Anette Preiss, Irmgard Wech
Publikováno v:
BMC Developmental Biology
BMC Developmental Biology, Vol 7, Iss 1, p 74 (2007)
BMC Developmental Biology, Vol 7, Iss 1, p 74 (2007)
Background Protein Kinase D (PKD) is an effector of diacylglycerol-regulated signaling pathways. Three isoforms are known in mammals that have been linked to diverse cellular functions including regulation of cell proliferation, differentiation, moti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35569f84663c493b2853f491f30853bc
http://europepmc.org/articles/PMC1933421
http://europepmc.org/articles/PMC1933421