Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sabrina Imam"'
Autor:
Kristen E. Pauken, Jernej Godec, Pamela M. Odorizzi, Keturah E. Brown, Kathleen B. Yates, Shin Foong Ngiow, Kelly P. Burke, Seth Maleri, Shannon M. Grande, Loise M. Francisco, Mohammed-Alkhatim Ali, Sabrina Imam, Gordon J. Freeman, W. Nicholas Haining, E. John Wherry, Arlene H. Sharpe
Publikováno v:
Cell Reports, Vol 31, Iss 13, Pp 107827- (2020)
Summary: The PD-1 pathway regulates dysfunctional T cells in chronic infection and cancer, but the role of this pathway during acute infection remains less clear. Here, we demonstrate that PD-1 signals are needed for optimal memory. Mice deficient in
Externí odkaz:
https://doaj.org/article/8fdbfcfc91f44b0bbe20702e1a1824ab
Autor:
Sevnur Kömürlü, Margret Bradley, Nikolai Smolin, Sabrina Imam, Raymond F Pauszek, Seth L Robia, David Millar, Emi E Nakayama, Tatsuo Shioda, Edward M Campbell
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0212888 (2019)
TRIM5α is an interferon inducible restriction factor which contributes to intrinsic defense against HIV infection by targeting the HIV capsid protein CA. Although human TRIM5α (huTRIM5α) does not potently inhibit HIV-1 infection, the ability of hu
Externí odkaz:
https://doaj.org/article/cb7efc497121450da84a870033e43ddf
Publikováno v:
International Journal of STD & AIDS. 34:366-373
The Centers for Disease Control and Prevention (CDC) published a health advisory on the occurrence of severe cases of mpox in immunocompromised patients, namely those with advanced HIV. Treatment options are limited, and very little is known about ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::267b60f52fd085dd732b7e40be5b16a8
https://doi.org/10.1177/09564624231152940
https://doi.org/10.1177/09564624231152940
Autor:
Edward M. Campbell, Anastasia Selyutina, Sabrina Imam, Jessica Mattick, Sevnur Kömürlü, Felipe Diaz-Griffero, Amani Eddins, Sarah Talley
Publikováno v:
Journal of Virology. 93
TRIM5α is an antiviral restriction factor that inhibits retroviral infection in a species-specific fashion. TRIM5α binds to and forms assemblies around the retroviral capsid. Following binding, poorly understood, ubiquitin-dependent events lead to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04652595c1d0dc2458e89662532d2396
https://doi.org/10.1128/jvi.00558-19
https://doi.org/10.1128/jvi.00558-19
Autor:
Seth Maleri, Keturah E. Brown, Sabrina Imam, Pamela M. Odorizzi, Shannon M. Grande, Arlene H. Sharpe, Kelly P. Burke, Kathleen B. Yates, Shin Foong Ngiow, E. John Wherry, Loise M. Francisco, Mohammed-Alkhatim Ali, Kristen E. Pauken, W. Nicholas Haining, Jernej Godec, Gordon J. Freeman
Publikováno v:
Cell Reports, Vol 31, Iss 13, Pp 107827-(2020)
Cell Rep
Cell Rep
Summary The PD-1 pathway regulates dysfunctional T cells in chronic infection and cancer, but the role of this pathway during acute infection remains less clear. Here, we demonstrate that PD-1 signals are needed for optimal memory. Mice deficient in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34da4c0988ea672f6ccc893045c30c46
https://doi.org/10.1016/j.celrep.2020.107827
https://doi.org/10.1016/j.celrep.2020.107827
Autor:
Sevnur Komurlu Keceli, Adarsh Dharan, Edward M. Campbell, Silvana Opp, Sabrina Imam, Omar Abdel-Rahim, Felipe Diaz-Griffero
Publikováno v:
Proceedings of the National Academy of Sciences. 114
Numerous viruses, including HIV-1, exploit the microtubule network to traffic toward the nucleus during infection. Although numerous studies have observed a role for the minus-end microtubule motor dynein in HIV-1 infection, the mechanism by which th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc24509c3206fb56a0d389ffb5af250
https://doi.org/10.1073/pnas.1712033114
https://doi.org/10.1073/pnas.1712033114
Autor:
David, Wolski, Peter K, Foote, Diana Y, Chen, Lia L, Lewis-Ximenez, Catherine, Fauvelle, Jasneet, Aneja, Andreas, Walker, Pierre, Tonnerre, Almudena, Torres-Cornejo, Daniel, Kvistad, Sabrina, Imam, Michael T, Waring, Damien C, Tully, Todd M, Allen, Raymond T, Chung, Jörg, Timm, W Nicholas, Haining, Arthur Y, Kim, Thomas F, Baumert, Georg M, Lauer
Publikováno v:
Immunity. 47(4)
Distinct molecular pathways govern the differentiation of CD8+ effector T cells into memory or exhausted T cells during acute and chronic viral infection but these are not well-studied in humans. Here, we employed an integrative systems immunology ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ec1a4fc0954d86f079e31f5528b2d844
https://pubmed.ncbi.nlm.nih.gov/29045899
https://pubmed.ncbi.nlm.nih.gov/29045899
Autor:
Margret Bradley, Sevnur Kömürlü, Sabrina Imam, Tatsuo Shioda, David P. Millar, Raymond F. Pauszek, Edward M. Campbell, Emi E. Nakayama, Seth L. Robia, Nikolai Smolin
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 3, p e0212888 (2019)
PLoS ONE, Vol 14, Iss 3, p e0212888 (2019)
TRIM5α is an interferon inducible restriction factor which contributes to intrinsic defense against HIV infection by targeting the HIV capsid protein CA. Although human TRIM5α (huTRIM5α) does not potently inhibit HIV-1 infection, the ability of hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7db4002643ab6ae2e8e62bb6c44cb94
https://doi.org/10.1371/journal.pone.0212888
https://doi.org/10.1371/journal.pone.0212888
Autor:
Thorsten R. Mempel, W. Nicholas Haining, Irina B. Mazo, Mario Perro, Sabrina Imam, Michael Quigley, Shaida Omid, Michael P Flynn, Scott Loughhead, Gabriela Alexe, Susanne Stutte, Jonathan L. Jesneck, Sarah E. Henrickson, Balimkiz Senman, Matteo Iannacone, Ulrich H. von Andrian
Publikováno v:
Immunity. 39(3):496-507
SummaryT cells are activated by antigen (Ag)-bearing dendritic cells (DCs) in lymph nodes in three phases. The duration of the initial phase of transient, serial DC-T cell interactions is inversely correlated with Ag dose. The second phase, character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e0bd57b5076c275378289aedb6ba6f
Autor:
Sabrina Imam, Sarah Talley, Thomas J. Hope, Edward M. Campbell, Adarsh Dharan, Christopher O'Connor, Rachel S. Nelson
TRIM5α is an interferon-inducible retroviral restriction factor that prevents infection by inducing the abortive disassembly of capsid cores recognized by its C-terminal PRY/SPRY domain. The mechanism by which TRIM5α mediates the disassembly of vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ab986082cb03a37d37ced8e79f85db
https://europepmc.org/articles/PMC4794682/
https://europepmc.org/articles/PMC4794682/
