Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Sabrina Haag"'
Autor:
Jonatan Tuncel, Jens Holmberg, Sabrina Haag, Malin Hultqvist Hopkins, Lena Wester-Rosenlöf, Stefan Carlsen, Peter Olofsson, Rikard Holmdahl
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-12 (2020)
Abstract Background CD4+ T cells play a central role during the early stages of rheumatoid arthritis (RA), but to which extent they are required for the perpetuation of the disease is still not fully understood. The aim of the current study was to ob
Externí odkaz:
https://doaj.org/article/08b3b89c10644f4fb103aca3fa958dbe
Autor:
Jonatan Tuncel, Sabrina Haag, Markus H Hoffmann, Anthony C Y Yau, Malin Hultqvist, Peter Olofsson, Johan Bäcklund, Kutty Selva Nandakumar, Daniela Weidner, Anita Fischer, Anna Leichsenring, Franziska Lange, Claus Haase, Shemin Lu, Percio S Gulko, Günter Steiner, Rikard Holmdahl
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155936 (2016)
BACKGROUND:To facilitate the development of therapies for rheumatoid arthritis (RA), the Innovative Medicines Initiative BTCure has combined the experience from several laboratories worldwide to establish a series of protocols for different animal mo
Externí odkaz:
https://doaj.org/article/829ef696d7ea419db77b35227d0406b8
Autor:
Jonatan Tuncel, Sabrina Haag, Anthony C Y Yau, Ulrika Norin, Amelie Baud, Erik Lönnblom, Klio Maratou, A Jimmy Ytterberg, Diana Ekman, Soley Thordardottir, Martina Johannesson, Alan Gillett, EURATRANS Consortium, Pernilla Stridh, Maja Jagodic, Tomas Olsson, Alberto Fernández-Teruel, Roman A Zubarev, Richard Mott, Timothy J Aitman, Jonathan Flint, Rikard Holmdahl
Publikováno v:
PLoS Genetics, Vol 10, Iss 2, p e1004151 (2014)
Genetic variation in the major histocompatibility complex (MHC) affects CD4∶CD8 lineage commitment and MHC expression. However, the contribution of specific genes in this gene-dense region has not yet been resolved. Nor has it been established whet
Externí odkaz:
https://doaj.org/article/626b76e763964d4b96c17efc72bbb0ba
Autor:
Soumya Badrinath, Maxence O. Dellacherie, Aileen Li, Shiwei Zheng, Xixi Zhang, Miguel Sobral, Jason W. Pyrdol, Kathryn L. Smith, Yuheng Lu, Sabrina Haag, Hamza Ijaz, Fawn Connor-Stroud, Tsuneyasu Kaisho, Glenn Dranoff, Guo-Cheng Yuan, David J. Mooney, Kai W. Wucherpfennig
Publikováno v:
Nature. 606:992-998
Most cancer vaccines target peptide antigens, necessitating personalization owing to the vast inter-individual diversity in major histocompatibility complex (MHC) molecules that present peptides to T cells. Furthermore, tumours frequently escape T ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967fb420c630f072c3768d5bd986d27f
https://doi.org/10.1038/s41586-022-04772-4
https://doi.org/10.1038/s41586-022-04772-4
Autor:
Urszula Uciechowska, Ida Andersson, Doreen Dobritzsch, Cecilia M. Lindgren, Sabrina Haag, Anna Linusson, Changrong Ge, Rikard Holmdahl, Lotta Berg, Jan Kihlberg
Publikováno v:
Organic & Biomolecular Chemistry. 13:6203-6216
Class II major histocompatibility complex (MHC) proteins are involved in initiation of immune responses to foreign antigens via presentation of peptides to receptors of CD4(+) T-cells. An analogous presentation of self-peptides may lead to autoimmune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be6e7c1e0a96243b24b57b05f8b1bc3
https://doi.org/10.1039/c5ob00395d
https://doi.org/10.1039/c5ob00395d
Autor:
Jonatan Tuncel, Sabrina Haag, Ida Andersson, Eric C. Peters, Daniel E. Mason, Rikard Holmdahl, Harald Burkhardt, Nadine Schneider
Publikováno v:
Arthritis & Rheumatology. 66:1440-1449
Objective To investigate type II collagen (CII) as a joint-specific target of the anti–citrullinated protein antibody (ACPA) response in rheumatoid arthritis (RA). Methods Potential citrullinated neoepitopes were identified by high-resolution tande
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::628c758bdef2c9dfca7673d9e771b1f4
https://doi.org/10.1002/art.38383
https://doi.org/10.1002/art.38383
Publikováno v:
European Journal of Immunology
Polymorphisms in the MHC class II (MHCII) genes are strongly associated with rheumatoid arthritis, supporting the importance of autoreactive T helper (Th) cells for the development of this disease. Here, we used pristane‐induced arthritis (PIA), in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::563402ca172972aee05e9638b07f5071
https://pubmed.ncbi.nlm.nih.gov/28012172
https://pubmed.ncbi.nlm.nih.gov/28012172
Autor:
Ulrika Norin, Sabrina Haag, Anthony C. Y. Yau, Miranda Houtman, Leonid Padyukov, Rikard Holmdahl, Jonatan Tuncel
Publikováno v:
Proceedings of the National Academy of Sciences. 113
Genome-wide association studies have revealed many genetic loci associated with complex autoimmune diseases. In rheumatoid arthritis (RA), the MHC gene HLA-DRB1 is the strongest candidate predicting disease development. It has been suggested that oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b6f5332e5c48ea0e8e82901d1fa7953
https://doi.org/10.1073/pnas.1600567113
https://doi.org/10.1073/pnas.1600567113
Autor:
Dorothea Rutishauser, Roman A. Zubarev, Sohel Mia, Tina Heyder, Sabrina Haag, Rikard Holmdahl, A. Jimmy Ytterberg, Charlotta Sandin, Maxie Kohler, Natalia V. Rivera, Åsa M. Wheelock, Johan Grunewald, Jan Wahlström, Vivianne Malmström, Anders Eklund, Nataliya K. Tarasova
Publikováno v:
Molecularcellular proteomics : MCP. 15(9)
Immune-mediated diseases strongly associating with human leukocyte antigen (HLA) alleles are likely linked to specific antigens. These antigens are presented to T cells in the form of peptides bound to HLA molecules on antigen presenting cells, e.g.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73330406605024cc5bbf13f27562496f
https://pubmed.ncbi.nlm.nih.gov/27452731
https://pubmed.ncbi.nlm.nih.gov/27452731
Autor:
Rikard Holmdahl, Roman A. Zubarev, Erik Jansson, Sabrina Haag, Patrick Merky, Jimmy Ytterberg, Cuiqin Li, Johan Bäcklund, Stefan Carlsen, Kutty-Selva Nandakumar
Publikováno v:
Annals of the Rheumatic Diseases; Vol 72
Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases
IntroductionCollagen-induced arthritis (CIA) has traditionally been performed in MHC class II Aq-expressing mice, whereas most genetically modified mice are on the C57BL/6 background (expressing the b haplotype of the major histocompatibility complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2bc0e93dec59bc29ba79928a91bedd4
https://doi.org/10.1136/annrheumdis-2012-202055
https://doi.org/10.1136/annrheumdis-2012-202055