Výsledky vyhledávání - "Sabrina Grimm"

Evidence supporting a role for the immune checkpoint protein B7-H3 in NK cell-mediated cytotoxicity against AML

Autor: Anudishi Tyagi, Stanley Ly, Fouad El-Dana, Bin Yuan, Appalaraju Jaggupilli, Sabrina Grimm, Marina Konopleva, Hans-Jörg Bühring, V. Lokesh Battula

Publikováno v: Blood. 139:2782-2796

We observed that the immune checkpoint protein B7-H3 is overexpressed in acute myeloid leukemia (AML) patients with poor treatment outcomes. Inhibition of B7-H3 expression or blocking of its activity using a novel monoclonal antibody (T-1A5) in AML c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1393000d391a9a1223e512d7ea393527
https://doi.org/10.1182/blood.2021014671

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Anti-B7-H3 Antibody (T-1A5) Blocks Immunomodulatory Function of B7-H3 and Enhances NK Cell-Mediated Cytotoxicity Against Acute Myeloid Leukemia Cells

Autor: Stanley Ly, Venkata Lokesh Battula, Sabrina Grimm, Bin Yuan, Anudishi Tyagi, Hans-Jörg Bühring, Fouad El-Dana

Publikováno v: Blood. 138:3336-3336

Background: The immune checkpoint molecule B7-H3 (CD276) is overexpressed in various solid tumors and hematological malignancies; however, its expression is limited in normal tissue, which makes it an attractive therapeutic target in cancer. Several

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc5075d8b43f88207f1cae0e9e73fef7
https://doi.org/10.1182/blood-2021-151535

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Abstract 3248: B7-H3, an immune checkpoint protein is overexpressed in AML and the blocking monoclonal antibodies enhance NK cell-mediated apoptosis in AML cells

Autor: Venkata Lokesh Battula, Bin Yuan, Sabrina Grimm, Michael Andreeff, Stanley Ly, Hans-Jörg Bühring

Publikováno v: Cancer Research. 79:3248-3248

Acute myeloid leukemia (AML) is the most common and aggressive acute leukemia found in adults. Immune checkpoint inhibition has led to important clinical advances in cancer therapy in recent years due to superior cure rates compared with standard the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f609cf30074bc245a90fea46c4cfcbf
https://doi.org/10.1158/1538-7445.am2019-3248

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Characterization of peripheral hematopoietic stem cells and monocytes in Parkinson's disease

Autor: Hans-Jörg Bühring, Richard Schaefer, Natalja Funk, Saskia Biskup, Sabrina Grimm, Thomas Gasser, Peter Wieghofer

Publikováno v: Movement Disorders. 28:392-395

Background Emerging evidence has highlighted the pivotal role of the immune system in neurodegenerative diseases. This study investigated the impact of progressive neurodegeneration on the differentiation and development of hematopoietic stem cells i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6923bd1a83ea3f385e25615a742ddad2
https://doi.org/10.1002/mds.25300

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Phenotypic and functional heterogeneity of human bone marrow- and amnion-derived MSC subsets

Autor: Hans-Jörg Bühring, Elisabeth Mortha, Flavianna Cerabona, Peter de Zwart, Kavitha Sivasubramaniyan, Christoph Faul, Lothar Kanz, Sabrina Grimm, Roshanak Ghazanfari, Abhishek Harichandan, Neli Petkova, Harald Abele, Wilhelm K. Aicher, Daniela Lehnen, Malgorzata Sobiesiak

Publikováno v: Annals of the New York Academy of Sciences. 1266:94-106

Bone marrow-derived mesenchymal stromal/stem cells (MSCs) are nonhematopoietic cells that are able to differentiate into osteoblasts, adipocytes, and chondrocytes. In addition, they are known to participate in niche formation for hematopoietic stem c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e9fa44eca3cc7ed0df37835ef846dd0
https://doi.org/10.1111/j.1749-6632.2012.06551.x

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Selection of radioresistant tumor cells and presence of ALDH1 activity in vitro

Autor: H. Peter Rodemann, Rainer Kehlbach, Julia Mihatsch, Claudia Lengerke, Mahmoud Toulany, Sabrina Grimm, Petra M. Bareiss

Publikováno v: Radiotherapy and Oncology. 99:300-306

Background Tumor resistance to radiotherapy has been hypothesized to be mediated by a tumor subpopulation, called cancer stem cells (CSCs). Based on the proposed function of CSCs in radioresistance, we explored the cancer stem cell properties of cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68587210b97e6eed219a243d49915776
https://doi.org/10.1016/j.radonc.2011.06.003

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Characterization of peripheral hematopoietic stem cells and monocytes in Parkinson's disease

Autor: Natalja, Funk, Peter, Wieghofer, Sabrina, Grimm, Richard, Schaefer, Hans-Jörg, Bühring, Thomas, Gasser, Saskia, Biskup

Publikováno v: Movement disorders 28(3), 392-395 (2013). doi:10.1002/mds.25300

Emerging evidence has highlighted the pivotal role of the immune system in neurodegenerative diseases. This study investigated the impact of progressive neurodegeneration on the differentiation and development of hematopoietic stem cells in the perip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2cd6c12a4b5c656ede0db23d281abcd9

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Phenotypic and functional heterogeneity of human bone marrow- and amnion-derived MSC subsets

Autor: Kavitha, Sivasubramaniyan, Daniela, Lehnen, Roshanak, Ghazanfari, Malgorzata, Sobiesiak, Abhishek, Harichandan, Elisabeth, Mortha, Neli, Petkova, Sabrina, Grimm, Flavianna, Cerabona, Peter, de Zwart, Harald, Abele, Wilhelm K, Aicher, Christoph, Faul, Lothar, Kanz, Hans-Jörg, Bühring

Publikováno v: Annals of the New York Academy of Sciences. 1266

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b9e2cf436e294bc40c8f3d4dc7bd1094
https://pubmed.ncbi.nlm.nih.gov/22901261

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