Kidney Dysfunction in Adult Offspring Exposed In Utero to Type 1 Diabetes Is Associated with Alterations in Genome-Wide DNA Methylation.

Autor: Jean-François Gautier, Raphaël Porcher, Charbel Abi Khalil, Naima Bellili-Munoz, Lila Sabrina Fetita, Florence Travert, Simeon-Pierre Choukem, Jean-Pierre Riveline, Samy Hadjadj, Etienne Larger, Philippe Boudou, Bertrand Blondeau, Ronan Roussel, Pascal Ferré, Eric Ravussin, François Rouzet, Michel Marre

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0134654 (2015)

Fetal exposure to hyperglycemia impacts negatively kidney development and function.Our objective was to determine whether fetal exposure to moderate hyperglycemia is associated with epigenetic alterations in DNA methylation in peripheral blood cells

Externí odkaz: https://doaj.org/article/3f09c623ffbe4a4aaff4e3731dc6f9cc

Sex Difference In the Effect of Fetal Exposure to Maternal Diabetes on Insulin Secretion

Autor: Raphaël Porcher, Charbel Abi Khalil, Jean-Pierre Riveline, Michel Marre, Gilberto Velho, Philippe Boudou, Simeon-Pierre Choukem, Eric Ravussin, Franck Mauvais-Jarvis, Etienne Larger, Ronan Roussel, Jean-François Gautier, Samy Hadjadj, Lila Sabrina Fetita, Fidaa Ibrahim

Publikováno v: Journal of the Endocrine Society

We previously showed that fetal exposure to maternal type 1 diabetes (T1D) is associated with altered glucose-stimulated insulin secretion in adult offspring. Here, we investigated whether this β-cell defect displays a sex dimorphism. Twenty-nine ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcabf509f3c06160d7b783c8ece3bcb7
https://doi.org/10.1210/js.2017-00482

One-year metreleptin improves insulin secretion in patients with diabetes linked to genetic lipodystrophic syndromes

Autor: Camille Vatier, J.P. Riveline, Sabrina Fetita, F. Andreelli, I. Madelaine, F. Travert, Philippe Boudou, Corinne Vigouroux, O. Lascols, C. Tchankou, J. Cahen, J.F. Gautier, L. Mathivon, Mc. Vantyghem, D. Morin, L. Deville, E. Mongeois, Yves Reznik, Jacques Young

Publikováno v: Diabetes, Obesity and Metabolism
Diabetes, Obesity and Metabolism, Wiley, 2016, 〈10.1111/dom.12606〉
Diabetes, Obesity and Metabolism, 2016, ⟨10.1111/dom.12606⟩
Diabetes, Obesity and Metabolism, Wiley, 2016, ⟨10.1111/dom.12606⟩

International audience; Recombinant methionyl human leptin (metreleptin) therapy was shown to improve hyperglycaemia, dyslipidaemia and insulin sensitivity in patients with lipodystrophic syndromes, but its effects on insulin secretion remain controv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9edde90229805fba014e5bce1a9cbc0
https://hal.sorbonne-universite.fr/hal-01259859

Clinical and Metabolic Features of Adult-Onset Diabetes Caused by ABCC8 Mutations

Autor: Martine Vaxillaire, Guillaume Charpentier, Agnès Hartemann, Yves Reznik, Sabrina Fetita, Philippe Froguel, Michel Polak, Jean-Pierre Riveline, Jean-François Gautier, Aurélie Dechaume, C. Petit, Elise Rousseau, J. Philippe

Publikováno v: Diabetes Care

OBJECTIVE Gain-of-function ABCC8/sulfonylurea (SU) receptor 1 mutations cause neonatal diabetes mellitus (NDM) or late-onset diabetes in adult relatives. Given the effectiveness of SU treatment in ABCC8-NDM patients, we further characterized late-ons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d7bdf664b6f128561df764db6aa274
https://doi.org/10.2337/dc11-1469

Kidney Dysfunction in Adult Offspring Exposed In Utero to Type 1 Diabetes Is Associated with Alterations in Genome-Wide DNA Methylation

Autor: Ronan Roussel, F. Travert, Jean-Pierre Riveline, Michel Marre, Naima Bellili-Muñoz, Jean-François Gautier, Pascal Ferré, B. Blondeau, François Rouzet, Lila Sabrina Fetita, E. Larger, Raphaël Porcher, Philippe Boudou, Simeon-Pierre Choukem, Eric Ravussin, Samy Hadjadj, Charbel Abi Khalil

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2015, 10 (8), pp.e0134654. ⟨10.1371/journal.pone.0134654⟩
PLoS ONE, 2015, 10 (8), pp.e0134654. ⟨10.1371/journal.pone.0134654⟩
PLoS ONE, Vol 10, Iss 8, p e0134654 (2015)
PLoS ONE, Public Library of Science, 2015, 10 (8), pp.e0134654. 〈10.1371/journal.pone.0134654〉

Background Fetal exposure to hyperglycemia impacts negatively kidney development and function. Objective Our objective was to determine whether fetal exposure to moderate hyperglycemia is associated with epigenetic alterations in DNA methylation in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407c1fd9e1ddf59be9c83c3cb1be8301
https://hal.archives-ouvertes.fr/hal-01233562/document