Methyl-CpG-binding (SmMBD2/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni.

Autor: Kathrin K Geyer, Sabrina E Munshi, Helen L Whiteland, Narcis Fernandez-Fuentes, Dylan W Phillips, Karl F Hoffmann

Publikováno v: PLoS Pathogens, Vol 14, Iss 6, p e1007107 (2018)

While schistosomiasis remains a significant health problem in low to middle income countries, it also represents a recently recognised threat to more economically-developed regions. Until a vaccine is developed, this neglected infectious disease is p

Externí odkaz: https://doaj.org/article/4fdda7941f26401a91fa677efc81d543

Corrigendum to 'the anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities' [Int. J. Parasitol. Drugs and Drug Resist. 8 (2018) 213-222]

Autor: Michael Squance, Kathrin K. Geyer, Daniel Berrar, Martin T. Swain, Toby Wilkinson, Karl F. Hoffmann, Cristian Chaparro, Martin Vickers, Sabrina E. Munshi

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance
Geyer, K K, Munshi, S E, Vickers, M, Squance, M, Wilkinson, T J, Berrar, D, Chaparro, C, Swain, M T & Hoffmann, K F 2018, ' Corrigendum to 'the anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities' [Int. J. Parasitol. Drugs and Drug Resist. 8 (2018) 213-222] ', International Journal for Parasitology: Drugs and Drug Resistance . https://doi.org/10.1016/j.ijpddr.2018.07.002

Uncontrolled host immunological reactions directed against tissue-trapped eggs precipitate a potentially lethal, pathological cascade responsible for schistosomiasis. Blocking schistosome egg production, therefore, presents a strategy for simultaneou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101c64fde9803b67764c18b4011b1998
https://pubmed.ncbi.nlm.nih.gov/29649665

The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni

Autor: Kathrin K, Geyer, Umar H, Niazi, David, Duval, Céline, Cosseau, Chad, Tomlinson, Iain W, Chalmers, Martin T, Swain, David J, Cutress, Utibe, Bickham-Wright, Sabrina E, Munshi, Christoph, Grunau, Timothy P, Yoshino, Karl F, Hoffmann

Publikováno v: PLoS Neglected Tropical Diseases

Background The debilitating human disease schistosomiasis is caused by infection with schistosome parasites that maintain a complex lifecycle alternating between definitive (human) and intermediate (snail) hosts. While much is known about how the def

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d8031b3d8ac6280cdea87024fe25f022
https://pubmed.ncbi.nlm.nih.gov/28510608