RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42

Autor: Benjamin Misselwitz, Sabrina Dilling, Pascale Vonaesch, Raphael Sacher, Berend Snijder, Markus Schlumberger, Samuel Rout, Manuel Stark, Christian von Mering, Lucas Pelkmans, Wolf‐Dietrich Hardt

Publikováno v: Molecular Systems Biology, Vol 7, Iss 1, Pp 1-19 (2011)

Abstract The pathogen Salmonella Typhimurium is a common cause of diarrhea and invades the gut tissue by injecting a cocktail of virulence factors into epithelial cells, triggering actin rearrangements, membrane ruffling and pathogen entry. One of th

Externí odkaz: https://doaj.org/article/6738d677760c4dd385b240ae10b09e45

Specific inhibition of diverse pathogens in human cells by synthetic microRNA-like oligonucleotides inferred from RNAi screens

Autor: Christian von Mering, Andreas Kaufmann, Shyan Huey Low, Mario Emmenlauer, Daniel Andritschke, Ari Helenius, Christoph Dehio, Andrea Franceschini, Neha Daga, Sabrina Dilling, Alain Casanova, Roger Meier, Saskia Kreibich, Lucas Pelkmans, Raquel Conde-Álvarez, Pauli Rämö, Wolf-Dietrich Hardt

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
Proceedings of the National Academy of Sciences

Systematic genetic perturbation screening in human cells remains technically challenging. Typically, large libraries of chemically synthesized siRNA oligonucleotides are used, each designed to degrade a specific cellular mRNA via the RNA interference

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec925518c04342c15c56f922510e9eb3

Two newly identified SipA domains (F1, F2) steer effector protein localization and contribute to Salmonella host cell manipulation

Autor: Benjamin Misselwitz, Rina Käppeli, Marcus Kremer, Sabrina Dilling, Andreas Müller, Wolf-Dietrich Hardt, Michael Wetter, Markus C. Schlumberger

Publikováno v: Molecular Microbiology. 65:741-760

Salmonella Typhimurium causes bacterial enterocolitis. The type III secretion system (TTSS)-1 is a key virulence determinant of S. Typhimurium mediating host cell invasion and acute enterocolitis. The TTSS-1 effector protein SipA is transported into

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9b4fc2cdbf26caa43923b5e4a438f6e
https://doi.org/10.1111/j.1365-2958.2007.05823.x

In Macrophages, Caspase-1 Activation by SopE and the Type III Secretion System-1 of S. Typhimurium Can Proceed in the Absence of Flagellin

Autor: Rina Käppeli, Pascal Songhet, Claudia Hoffmann, Sabrina Dilling, Rudi Beyaert, Wolf-Dietrich Hardt, Marlies Galle, Andreas Müller

Publikováno v: PLoS ONE, 5 (8)
PLoS ONE, Vol 5, Iss 8, p e12477 (2010)
PLoS ONE
PLOS ONE

The innate immune system is of vital importance for protection against infectious pathogens. Inflammasome mediated caspase-1 activation and subsequent release of pro-inflammatory cytokines like IL-1β and IL-18 is an important arm of the innate immun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adab7dba6b362e3ca96b72cdea7f3f16
https://hdl.handle.net/20.500.11850/22234

Regulation of caffeate respiration in the acetogenic bacterium Acetobacterium woodii

Autor: Frank Imkamp, Volker Müller, Sabrina Dilling, Silke Schmidt

Publikováno v: Applied and environmental microbiology. 73(11)

The anaerobic acetogenic bacterium Acetobacterium woodii can conserve energy by oxidation of various substrates coupled to either carbonate or caffeate respiration. We used a cell suspension system to study the regulation and kinetics of induction of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0325e805a991fade362b76de9b172c
https://pubmed.ncbi.nlm.nih.gov/17416687