Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sabrina Contino"'
Autor:
Devkee M. Vadukul, Céline Vrancx, Pierre Burguet, Sabrina Contino, Nuria Suelves, Louise C. Serpell, Loïc Quinton, Pascal Kienlen-Campard
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract A key hallmark of Alzheimer’s disease is the extracellular deposition of amyloid plaques composed primarily of the amyloidogenic amyloid-β (Aβ) peptide. The Aβ peptide is a product of sequential cleavage of the Amyloid Precursor Protein
Externí odkaz:
https://doaj.org/article/cffde72cfd7a458c9a29c038453f9d37
Autor:
Sabrina Contino, Nuria Suelves, Céline Vrancx, Devkee M. Vadukul, Valery L. Payen, Serena Stanga, Luc Bertrand, Pascal Kienlen-Campard
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2021)
Presenilin 1 (PS1) and Presenilin 2 (PS2) are predominantly known as the catalytic subunits of the γ-secretase complex that generates the amyloid-β (Aβ) peptide, the major constituent of the senile plaques found in the brain of Alzheimer's disease
Externí odkaz:
https://doaj.org/article/b607f326c9de489090109092167bf221
Autor:
Sabrina Contino, Paolo E. Porporato, Matthew Bird, Claudia Marinangeli, Rémi Opsomer, Pierre Sonveaux, Françoise Bontemps, Ilse Dewachter, Jean-Noël Octave, Luc Bertrand, Serena Stanga, Pascal Kienlen-Campard
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Mitochondrial dysfunction plays a pivotal role in the progression of Alzheimer's disease (AD), and yet the mechanisms underlying the impairment of mitochondrial function in AD remain elusive. Recent evidence suggested a role for Presenilins (PS1 or P
Externí odkaz:
https://doaj.org/article/574ed7eaf3ba431a9f1a58934cde32af
Autor:
Loïc Quinton, Ludovic D'Auria, Vincent Van Pesch, Nuria Suelves, Céline Vrancx, Bernard Hanseeuw, Pascal Kienlen-Campard, Devkee M. Vadukul, Florian Perrin, Sabrina Contino
Publikováno v:
Molecular Neurobiology
The β-amyloid peptide (Aβ) is the main constituent of senile plaques, a typical hallmark of Alzheimer’s disease (AD). Monomeric Aβ is generated through sequential processing of the amyloid precursor protein (APP), with a final step involving γ-
Autor:
Luc Bertrand, Nuria Suelves, Serena Stanga, Sabrina Contino, Valéry Payen, Devkee M. Vadukul, Céline Vrancx, Pascal Kienlen-Campard
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2021)
Frontiers in Neuroscience
Frontiers in Neuroscience, Vol. 14, p. 586108 (2021)
Frontiers in Neuroscience
Frontiers in Neuroscience, Vol. 14, p. 586108 (2021)
Presenilins 1 and 2 (PS1 and PS2) are predominantly known as the catalytic subunits of the γ-secretase complex which generates the amyloid-β (Aβ) peptide, the major constituent of the senile plaques found in the brain of Alzheimer’s disease (AD)
Autor:
Pascal Kienlen-Campard, Nuria Suelves, Devkee M. Vadukul, Céline Vrancx, Ludovic D'Auria, Loïc Quinton, Vincent Van Pesch, Bernard Hanseeuw, Florian Perrin, Sabrina Contino
BackgroundThe β-amyloid peptide (Aβ) plays a key role in Alzheimer’s disease. After its production by catabolism of the amyloid precursor protein (APP) through the action of presenilin 1 (PS1)- or presenilin 2 (PS2)-dependent γ-secretases, monom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aed0003b182412b42af7810749e53d4
https://doi.org/10.21203/rs.3.rs-138906/v1
https://doi.org/10.21203/rs.3.rs-138906/v1
Autor:
Céline Vrancx, Pascal Kienlen-Campard, Nuria Suelves, Pierre Burguet, Sabrina Contino, Devkee M. Vadukul, Loïc Quinton, Louise C. Serpell
A key hallmark of Alzheimer’s disease (AD) is the extracellular deposition of amyloid plaques composed primarily of the amyloidogenic amyloid-β (Aβ) peptide. The Aβ peptide is a product of sequential cleavage of the Amyloid Precursor Protein (AP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4827fc20921942084933039f02ee82a8
https://doi.org/10.1101/2020.12.15.422916
https://doi.org/10.1101/2020.12.15.422916
Autor:
Céline Vrancx, Pierre J. Doyen, Bernadette Tasiaux, Serena Stanga, Maxime Vergouts, Pascal Kienlen-Campard, Roberta Gualdani, Nathalie Pierrot, Philippe Gailly, Jean-Noël Octave, Anna Doshina, Rémi Opsomer, Florian Perrin, Sabrina Contino
Publikováno v:
eNeuro, Vol. 7, no. 3, p. ENEURO.0322-19.202 [1-18] (2020)
eNeuro
eNeuro
Visual Abstract
The amyloid precursor protein (APP) has been extensively studied as the precursor of the β-amyloid (Aβ) peptide, the major component of the senile plaques found in the brain of Alzheimer’s disease (AD) patients. However, the
The amyloid precursor protein (APP) has been extensively studied as the precursor of the β-amyloid (Aβ) peptide, the major component of the senile plaques found in the brain of Alzheimer’s disease (AD) patients. However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177f160d38cf853ee72492a0b42d18a3
https://hdl.handle.net/2078.1/230453
https://hdl.handle.net/2078.1/230453
Autor:
Doyen P, Bernadette Tasiaux, Pascal Kienlen-Campard, Jean-Noël Octave, Vergouts M, Nathalie Pierrot, Rémi Opsomer, Serena Stanga, Florian Perrin, Sabrina Contino, Anna Doshina, Céline Vrancx
Sequential proteolysis of the amyloid precursor protein (APP) and amyloid-β peptide (Aβ) release is an upstream event in Alzheimer’s disease (AD) pathogenesis. The function of APP in neuronal physiology is still, however, poorly understood. Along
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1733b32a355feec3cfc5b5a1e874f70
https://doi.org/10.1101/504340
https://doi.org/10.1101/504340
Autor:
Ilse Dewachter, Pierre Sonveaux, Pascal Kienlen-Campard, Serena Stanga, Luc Bertrand, Sabrina Contino, Matthew Bird, Rémi Opsomer, Françoise Bontemps, Paolo E. Porporato, Claudia Marinangeli, Jean-Noël Octave
Publikováno v:
Article
Frontiers in Physiology, Vol. 8, p. 796 [1-11] (2017)
Frontiers in Physiology
Frontiers in Physiology, Vol 8 (2017)
Frontiers in Physiology, Vol. 8, p. 796 [1-11] (2017)
Frontiers in Physiology
Frontiers in Physiology, Vol 8 (2017)
Mitochondrial dysfunction plays a pivotal role in the progression of Alzheimer's disease (AD), and yet the mechanisms underlying the impairment of mitochondrial function in AD remain elusive. Recent evidence suggested a role for Presenilins (PS1 or P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93636ef29227b489376e32ad0228e0d
http://hdl.handle.net/1942/30267
http://hdl.handle.net/1942/30267