Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Sabrina Butt-Gueulle"'
1
Synthesis and structure-affinity relationships of selective high-affinity 5-HT(4) receptor antagonists: application to the design of new potential single photon emission computed tomography tracers
Autor: Fabienne Dulin, Noé Dumas, Céline Ballandonne, Christine Fossey, Thomas Cailly, Emmanuelle Dubost, Frédéric Fabis, Rosa Magnelli, Jana Sopkova de-Oliveira Santos, Sabrina Butt-Gueulle, Philippe Millet, Yves Charnay, Sylvain Rault, Daniel H. Caignard
Publikováno v: Journal of medicinal chemistry
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2012, 55 (22), pp.9693-9707. ⟨10.1021/jm300943r⟩
Journal of Medicinal Chemistry, Vol. 55, No 22 (2012) pp. 9693-9707
The work described herein aims at finding new potential ligands for the brain imaging of 5-HT(4) receptors (5-HT(4)Rs) using single-photon emission computed tomography (SPECT). Starting from the nonsubstituted phenanthridine compound 4a, exhibiting a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0bdc3552310c4e0bed411a9c10bb52
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2
Novel antagonists of serotonin-4 receptors: Synthesis and biological evaluation of pyrrolothienopyrazines
Autor: Sabrina Butt-Gueulle, Stephane Lemaitre, Cyril Daveu, Ronan Bureau, Alban Lepailleur, Véronique Lelong-Boulouard, Pascal Duchatelle, Bruno Pfeiffer, François Dauphin, Sylvain Rault, Michel Boulouard, Aline Dumuis, Frank Lezoualc'h
Publikováno v: Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2009, 17 (6), pp.2607-22. ⟨10.1016/j.bmc.2008.11.045⟩
International audience; Based on the definition of a 5-HT(4) receptor antagonist pharmacophore, a series of pyrrolo[1,2-a]thieno[3,2-e] and pyrrolo[1,2-a]thieno[2,3-e] pyrazine derivatives were designed, prepared, and evaluated to determine the prope
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8db7902e5d80abde4c9cbf5c8b4e54
https://doi.org/10.1016/j.bmc.2008.11.045
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3
Pharmacophores of 5-HT4 Receptor Ligands: Experience of CERMN and Implications for Drug Design
Autor: Cyril Daveu, Stephane Lemaitre, Ronan Bureau, Thibault Varin, François Dauphin, Jean-Charles Lancelot, Aurélien Lesnard, Sylvain Rault, Sabrina Butt-Gueulle, Alban Lepailleur
Publikováno v: Current Computer Aided-Drug Design. 4:199-208
The definitions of pharmacophores for 5-HT4 receptor agonists and antagonists are described in this review. These pharmacophores were keys in the design of new selective ligands for this receptor, starting generally from 5-HT3 receptor ligands. Our l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0ca80d0832ea37d1d24c430da479124
https://doi.org/10.2174/157340908785747384
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4
Novel aminoethylbiphenyls as 5-HT7 receptor ligands
Autor: Alban Lepailleur, Ronan Bureau, Frédéric Fabis, Sabrina Butt-Gueulle, Magalie Paillet-Loilier, Catherine Delarue, François Dauphin, Hubert Vaudry, Aurélien Lesnard, Sylvain Rault
Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2007, 17 (11), pp.3018-22. ⟨10.1016/j.bmcl.2007.03.054⟩
International audience; The synthesis of a series of aminoethylbiphenyls as novel 5-HT(7) receptor ligands is described. The novel derivatives exhibit high affinity for the 5-HT(7) receptor with selectivity toward 5-HT(1A) receptor.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25cb983708f08f4990c113b99d2a8638
https://doi.org/10.1016/j.bmcl.2007.03.054
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5
Anti-NR1 N-terminal-domain vaccination unmasks the crucial action of tPA on NMDA-receptor-mediated toxicity and spatial memory
Autor: Hervé Castel, Omar Touzani, Denis Vivien, Eric Maubert, Karim Benchenane, Carine Ali, François Dauphin, Véronique Agin, Michel Boulouard, Robert Dantzer, José P. López-Atalaya, Sabrina Butt-Gueulle, Benoit D. Roussel, R. M. Bluthe, Mónica Fernández-Monreal
Publikováno v: Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2007, 120 (Pt 4), pp.578-85. 〈10.1242/jcs.03354〉
Journal of Cell Science, Company of Biologists, 2007, 120 (Pt 4), pp.578-585. ⟨10.1242/jcs.03354⟩
International audience; Fine-tuning of NMDA glutamatergic receptor signalling strategically controls crucial brain functions. This process depends on several ligands and modulators, one of which unexpectedly includes the serine protease tissue-type p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::607a15d8b363effd0f2fd5547248dee3
https://doi.org/10.1242/jcs.03354
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6
Synthesis of dual AChE/5-HT4 receptor multi-target directed ligands
Autor: Céline Ballandonne, Jana Sopkova-de Oliveira Santos, Cédric Lecoutey, Fabienne Dulin, Sophie Corvaisier, Christophe Rochais, Alban Lepailleur, Sabrina Butt-Gueulle, Patrick Dallemagne, David Genest
Publikováno v: MedChemComm
MedChemComm, Royal Society of Chemistry, 2012, 3, pp.627-634
The synthesis of novel pyrrolothienopyrazines has been achieved with the aim to bring together in a sole compound both AChE inhibitory effect and 5-HT4R agonist activity. These Multi-Target Directed Ligands might theoretically alleviate the cognitive
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d795466fae7d44969c5c8277eaf4694
https://hal.archives-ouvertes.fr/hal-00764795
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7
Cyclopropyl-tryptamine Analogues: Synthesis and Biological Evaluation as 5-HT6 Receptor Ligands
Autor: Jan Szymoniak, Frédéric Fabis, Philippe Bertus, Claude Szalata, Janos Sapi, Stéphane Gérard, Sylvain Rault, Sabrina Butt-Gueulle
Publikováno v: ChemMedChem
ChemMedChem, Wiley-VCH Verlag, 2012, 55, pp.70-73. ⟨10.1002/cmdc.201200396⟩
ChemMedChem, Wiley-VCH Verlag, 2013, 8 (1), pp.70-73. ⟨10.1002/cmdc.201200396⟩
Conformational restrictions: Based on the pharmacophore model for 5-HT(6) receptor ligands (shown), tryptamine analogues bearing a cyclopropyl ring on the α-position of the tryptamine side chain were synthesized and evaluated against 5-HT receptors.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d1fb42bc6ab7cf70e77ad0d03cf9f6
https://hal.archives-ouvertes.fr/hal-00764886
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