Výsledky vyhledávání - "Sabrina Blumer"

Akademický článek

The use of cultured human alveolar basal cells to mimic honeycomb formation in idiopathic pulmonary fibrosis

Autor: Sabrina Blumer, Petra Khan, Nataliia Artysh, Linda Plappert, Spasenija Savic, Lars Knudsen, Danny Jonigk, Mark P. Kuehnel, Antje Prasse, Katrin E. Hostettler

Publikováno v: Respiratory Research, Vol 25, Iss 1, Pp 1-14 (2024)

Abstract Background Honeycomb cysts (HC) within the alveolar region are distinct histopathological features in the lungs of idiopathic pulmonary fibrosis (IPF) patients. HC are lined with a single-or stratified layer of basal cells (BC), or with a br

Externí odkaz: https://doaj.org/article/853d69fcaa924208a376d6da546282e9

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Akademický článek

Basal-Like Cell-Conditioned Medium Exerts Anti-Fibrotic Effects In Vitro and In Vivo

Autor: Petra Khan, Kleanthis Fytianos, Sabrina Blumer, Julien Roux, Amiq Gazdhar, Spasenija Savic, Lars Knudsen, Danny Jonigk, Mark P. Kuehnel, Sofia Mykoniati, Michael Tamm, Thomas Geiser, Katrin E. Hostettler

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)

In idiopathic pulmonary fibrosis (IPF), basal-like cells are atypically present in the alveolar region, where they may affect adjacent stromal cells by paracrine mechanisms. We here aimed to confirm the presence of basal-like cells in peripheral IPF

Externí odkaz: https://doaj.org/article/f2ebaa7eeea74c47bb55753b9f5016b3

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Akademický článek

Alveolar Basal Cells Differentiate towards Secretory Epithelial- and Aberrant Basaloid-like Cells In Vitro

Autor: Petra Khan, Julien Roux, Sabrina Blumer, Lars Knudsen, Danny Jonigk, Mark P. Kuehnel, Michael Tamm, Katrin E. Hostettler

Publikováno v: Cells, Vol 11, Iss 11, p 1820 (2022)

In idiopathic pulmonary fibrosis (IPF), keratin (KRT)17+/KRT5+ basal and KRT17+/KRT5− aberrant basaloid cells are atypically present within the alveolar space. We previously described the fibrosis-enriched outgrowth of alveolar basal cells from per

Externí odkaz: https://doaj.org/article/1708ccc134164a87a60959347ae9b281

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Akademický článek

IPF-Fibroblast Erk1/2 Activity Is Independent from microRNA Cluster 17-92 but Can Be Inhibited by Treprostinil through DUSP1

Autor: Sabrina Blumer, Lei Fang, Wei-Chih Chen, Petra Khan, Katrin Hostettler, Michael Tamm, Michael Roth, Christopher Lambers

Publikováno v: Cells, Vol 10, Iss 11, p 2836 (2021)

Idiopathic pulmonary fibrosis (IPF) is a progressive terminal lung disease, and therapies aim to block fibrosis. Fibroblast proliferation is controlled by C/EBP-β, microRNA cluster 17-92 (miR17-92), and Erk1/2 mitogen-activated protein kinase. This

Externí odkaz: https://doaj.org/article/1c3b0218fdf9491ea0dc4bc75a99dac4

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Basal-Like Cell-Conditioned Medium Exerts Anti-Fibrotic Effects

Autor: Petra, Khan, Kleanthis, Fytianos, Sabrina, Blumer, Julien, Roux, Amiq, Gazdhar, Spasenija, Savic, Lars, Knudsen, Danny, Jonigk, Mark P, Kuehnel, Sofia, Mykoniati, Michael, Tamm, Thomas, Geiser, Katrin E, Hostettler

Publikováno v: Frontiers in bioengineering and biotechnology. 10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::733d48f181ebedc3ad3acb1b31983065
https://pubmed.ncbi.nlm.nih.gov/35350187

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In vitro culture of aberrant basal-like cells from fibrotic lung tissue

Autor: Spasenija Savic, Amiq Gazdhar, Petra Khan, Thomas Geiser, Michael Tamm, Katrin Hostettler, Lars Knudsen, Julien Roux, Sabrina Blumer, Lei Fang, Danny Jonigk, Mark Kuehnel

RationaleIn idiopathic pulmonary fibrosis (IPF) atypical epithelial cells are present in the alveolar compartment. Their origin and contribution to IPF pathogenesis is unknown. We recently cultured a distinct population of cells, which readily grew f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9613320beec10191240e81fc3adf88f0
https://doi.org/10.1101/2020.08.16.247866

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