Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sabrina Amar"'
Publikováno v:
Libyan Journal of Medicine, Vol 19, Iss 1 (2024)
ABSTRACTAim: Functional gastrointestinal (GI) disorders are recognized as a major public health concern worldwide. These disorders involve persistent digestive symptoms indicative of digestive tract dysfunction.Materials and Methods: A survey examini
Externí odkaz:
https://doaj.org/article/932cdc2b8fc64a778766d96dec09b7ec
Autor:
Alex Y. Strongin, Sabrina Amar, Rafael Fridman, Manishabrata Bhowmick, Gregg B. Fields, Jian Cao, Stephen J. Weiss, Sonia Pahwa
Publikováno v:
Chem Biol Drug Des
Quantitative assessment of MT1-MMP cell surface-associated proteolytic activity remains undefined. Presently, MT1-MMP was stably expressed and a cell-based FRET assay developed to quantify activity towards synthetic collagen-model triple-helices. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80e5c26fa4a1e0a401560b7bc7d8cbe
https://doi.org/10.1111/cbdd.13450
https://doi.org/10.1111/cbdd.13450
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1864:1940-1951
The proteolytic processing of collagen (collagenolysis) is critical in development and homeostasis, but also contributes to numerous pathologies. Mammalian interstitial collagenolytic enzymes include members of the matrix metalloproteinase (MMP) fami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab0a2b78fae3a704f6372902f373c7c
https://doi.org/10.1016/j.bbamcr.2017.04.015
https://doi.org/10.1016/j.bbamcr.2017.04.015
Autor:
Sabrina Amar, Gregg B. Fields, Patrick Cosme, Michal Tokmina-Roszyk, Andrew C. Terentis, Yury Gogotsi, Vadym Mochalin, Dorota Tokmina-Roszyk, Anna M. Knapinska
Publikováno v:
Peptide Science. 104:186-195
Nanodiamonds (NDs) have received considerable attention as potential drug delivery vehicles. NDs are small (∼5 nm diameter), can be surface modified in a controllable fashion with a variety of functional groups, and have little observed toxicity in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc68355193f79e5d488d7cd76adafc4
https://doi.org/10.1002/bip.22636
https://doi.org/10.1002/bip.22636
Publikováno v:
ACS Combinatorial Science
Primary hits that arise from screening one bead one compound (OBOC) libraries against a target of interest rarely have high potency. However, there has been little work focused on the development of an efficient workflow for primary hit improvement.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc757714bd8680d213916bf744cdfc4
https://doi.org/10.1021/co500154e
https://doi.org/10.1021/co500154e
Autor:
Gregg B. Fields, Sabrina Amar
Publikováno v:
Expert Review of Proteomics. 12:445-447
Analysis of matrix metalloproteinases (MMPs) expression profiles in various pathologies correlated with their presence in promoting disease progression. Drugs were designed to inhibit MMPs in an extreme manner by chelating the active site zinc ion. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71de482989b55bc5deeef6c87b3e500b
https://doi.org/10.1586/14789450.2015.1069190
https://doi.org/10.1586/14789450.2015.1069190
Autor:
Sabrina Amar, Anna M. Knapinska, Zhong He, Claudia Zylberberg, Sandro Matosevic, Gregg B. Fields
Cell isolation methods for therapeutic purposes have seen little advancement over the years. The original methods of stem cell and islet isolation using bacterial collagenases were developed in the early 1980s and are still used today. Bacterial coll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c8621495b7e5952f72f3f9ee8f8a0a7
https://europepmc.org/articles/PMC5054980/
https://europepmc.org/articles/PMC5054980/
Autor:
Gregg B. Fields, Janelle L. Lauer, Linda Cerofolini, Claudio Luchinat, Tommaso Martelli, Marco Fragai, Sabrina Amar
Publikováno v:
Scientific Reports
Europe PubMed Central
Europe PubMed Central
Cell surface proteolysis is an integral yet poorly understood physiological process. The present study has examined how the pericellular collagenase membrane-type 1 matrix metalloproteinase (MT1-MMP) and membrane-mimicking environments interplay in s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a0f09eadd7862007409ab9113e38fd
Publikováno v:
Peptide Chemistry and Drug Design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc9862819fc1c3ff8f0bb41e5c941637
https://doi.org/10.1002/9781118995303.ch4
https://doi.org/10.1002/9781118995303.ch4
Publikováno v:
PROTEOMICS. 17:1600389
Remodeling of the extracellular matrix (ECM) is crucial in development and homeostasis, but also has a significant role in disease progression. Two metalloproteinase families, the matrix metalloproteinases (MMPs) and a disintegrin and metalloprotease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd14c227778c02ab9fe3b4c5c23b730d
https://doi.org/10.1002/pmic.201600389
https://doi.org/10.1002/pmic.201600389