Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Sabrina X. Zhao"'
Publikováno v:
Drug Metabolism and Pharmacokinetics. 26:266-279
The metabolism of 3,4-dihydro-7-[4-(1-naphthalenyl)-1-piperazinyl]butoxy]-1,8-naphthyridin-2(1H)-one (NPBN) was investigated in rats. Animals were administered 30 mg/kg NPBN that was labeled with both tritium and carbon-14. The mass recovery of drug-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18f575cc7dc46a09dbf4f4a40cf649b
https://doi.org/10.2133/dmpk.dmpk-10-rg-109
https://doi.org/10.2133/dmpk.dmpk-10-rg-109
Autor:
John R. Soglia, Hao Sun, Jonathan N. Bauman, Zhuang Miao, Jianke Li, Angel Guzman-Perez, Kenneth J. DiRico, Tim F. Ryder, Scott W. Bagley, Kosea S. Frederick, Bruce M. Bechle, Sabrina X. Zhao, Michael P. Zawistoski, Daniel P. Walker, Kevin K.-C. Liu, Mary Theresa Didiuk, Amit S. Kalgutkar, Joel Morris, Robert M. Oliver, Ryan Michael Kelley, John William Benbow, David A. Griffith, Chandra Prakash
Publikováno v:
Chemical Research in Toxicology. 23:1115-1126
The synthesis and structure-activity relationship studies on 5-trifluoromethylpyrido[4,3-d]pyrimidin-4(3H)-ones as antagonists of the human calcium receptor (CaSR) have been recently disclosed [ Didiuk et al. ( 2009 ) Bioorg. Med. Chem. Lett. 19 , 45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24e5e5f32d0c8dbdd97463c65363b37
https://doi.org/10.1021/tx100137n
https://doi.org/10.1021/tx100137n
Autor:
Amit S. Kalgutkar, Edna F. Choo, Heather L. Hatch, Yi-an Bi, Hang T. Nguyen, David B. Duignan, Kosea S. Frederick, Sabrina X. Zhao, Scott D. Campbell, Rouchelle J. Mireles, Bo Feng, Diana C. Kazolias, Ralph E. Davidson
Publikováno v:
Drug Metabolism and Disposition. 35:2111-2118
The role of transporters in the disposition of (+)-2-[4-({[2-(benzo[1,3]dioxol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid (CP-671,305), an orally active inhibitor of phosphodiesterase-4, was examined. In bile duct-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731758e9765afeec53807ae21ec7d2e5
https://doi.org/10.1124/dmd.107.016162
https://doi.org/10.1124/dmd.107.016162
Autor:
Arneric Sp, Karen K. Cook, Thomas J. Raub, Bruce N. Rogers, Mark L. Wolfe, Eric Jon Jacobsen, Vincent E. Groppi, Carey G, Brian A. Staton, Daniel P. Walker, Raymond S. Hurst, Luz A. Cortes-Burgos, Rodney R. Walters, Donn G. Wishka, Theron M. Wall, Jia S, Hanchar Aj, Karen M. Yates, Steven B. Sands, Bruce A. Thornburgh, Gold Lh, Soglia, Jason K. Myers, Franklin S, Steven Charles Reitz, Sabrina X. Zhao, Amit S. Kalgutkar, Nicole R. Higdon, Olson Kl, Erik H. F. Wong, Mihály Hajós, William E. Hoffmann
Publikováno v:
Journal of Medicinal Chemistry. 49:4425-4436
N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide (14, PHA-543,613), a novel agonist of the alpha7 neuronal nicotinic acetylcholine receptor (alpha7 nAChR), has been identified as a potential treatment of cognitive deficits in sch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09fbbbb19eb89de61edd6e606a68da00
https://doi.org/10.1021/jm0602413
https://doi.org/10.1021/jm0602413
Autor:
John R. Soglia, Sabrina X. Zhao, Amit S. Kalgutkar, Cornelis E.C.A. Hop, Kirk R. Henne, Alfin D. N. Vaz, Mary E. Lame, Claire Collin
Publikováno v:
Chemico-Biological Interactions. 155:10-20
Therapy with the antidepressant trazodone has been associated with several cases of idiosyncratic hepatotoxicity. While the mechanism of hepatotoxicity remains unknown, it is possible that reactive metabolites of trazodone play a causative role. Stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0cb63862b250b107932188c45732708
https://doi.org/10.1016/j.cbi.2005.03.036
https://doi.org/10.1016/j.cbi.2005.03.036
Autor:
Mark J. Cole, Shawn Harriman, Sabrina X. Zhao, John R. Soglia, James G. Boyd, Leonard G. Contillo, John T. Barberia
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 36:105-116
An in vitro reactive intermediate screening assay, incorporating the use of the close analog of glutathione, glutathione ethyl ester (GSH-EE) as a conjugating agent, was developed to identify compounds that form reactive intermediates in an in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abcf40857baa17b709d390680a693108
https://doi.org/10.1016/j.jpba.2004.04.019
https://doi.org/10.1016/j.jpba.2004.04.019
Autor:
R. Scott Obach, Jonathon N Bauman, Sabrina X. Zhao, Amit S. Kalgutkar, Sakambari Tripathy, Wing Lam, Joan M. Kelly
Publikováno v:
Chemical research in toxicology. 22(2)
In vitro covalent binding studies in which xenobiotics are shown to undergo metabolism-dependent covalent binding to macromolecules have been commonly used to shed light on the biochemical mechanisms of xenobiotic-induced toxicity. In this paper, 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21756478851b9a1bf4470c35d2eb714c
https://pubmed.ncbi.nlm.nih.gov/19161298
https://pubmed.ncbi.nlm.nih.gov/19161298
Autor:
Mark J. Cole, John P. Umland, Matt D. Troutman, Mike West, Veronica Zelesky, Kevin M. Whalen, Cornelis E.C.A. Hop, Kelly Jenkins, Suzanne Krueger, John R. Soglia, Walter Mitchell, Stefan J. Steyn, Theodore E. Liston, Ralph E. Davidson, John S. Janiszewski, James Federico, Rebecca Lebowitz, David B. Duignan, Mark Snyder, Sabrina X. Zhao, Christine Taylor
Publikováno v:
Current drug metabolism. 9(9)
Evaluation and optimization of drug metabolism and pharmacokinetic data plays an important role in drug discovery and development and several reliable in vitro ADME models are available. Recently higher throughput in vitro ADME screening facilities h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf04fdfcf299c68d4bb5442bcd49710a
https://pubmed.ncbi.nlm.nih.gov/18991580
https://pubmed.ncbi.nlm.nih.gov/18991580
Autor:
Matthew F. Dunn, John Charles Kath, Anil Mistry, F. Christopher Bi, Daniel Tyler Richter, Sabrina X. Zhao, Leonard Buckbinder, Jacquelyn Klug-McLeod, Daniel W. Kung, Gary Erik Aspnes, Michael P. Zawistoski, Robert M. Oliver, Seungil Han, Peter C. Bonnette, Ethan Ung, Molly A. McGlynn, Angel Guzman-Perez, Catherine Angela Hulford, Matthew C. Griffor, John R. Soglia, Jonathan N. Bauman, Michael Joseph Luzzio, Daniel P. Walker, Christopher Autry, Amit S. Kalgutkar, W. Gregory Roberts, Jian-Cheng Li, Beth Cooper
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(23)
The synthesis and SAR for a series of diaminopyrimidines as PYK2 inhibitors are described. Using a combination of library and traditional medicinal chemistry techniques, a FAK-selective chemical series was transformed into compounds possessing good P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d4e40768ab5124987956906e550066
https://pubmed.ncbi.nlm.nih.gov/18951788
https://pubmed.ncbi.nlm.nih.gov/18951788
Publikováno v:
Chemical research in toxicology. 21(9)
In vitro covalent binding assessments of drugs have been useful in providing retrospective insights into the association between drug metabolism and a resulting toxicological response. On the basis of these studies, it has been advocated that in vitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b7082a0bf3be5fc7ae993cbfa44605d
https://pubmed.ncbi.nlm.nih.gov/18690722
https://pubmed.ncbi.nlm.nih.gov/18690722